Enantioselective synthesis of tetrahydroisoquinolines via catalytic intramolecular asymmetric reductive amination

2021 ◽  
Author(s):  
Ruixia Liu ◽  
Jingkuo Han ◽  
Bin Li ◽  
Xian Liu ◽  
Zhao Wei ◽  
...  
Keyword(s):  
Reductive Amination ◽  
Enantioselective Synthesis ◽  
Iridium Complex ◽  
Highly Efficient ◽  
Efficient Access

A highly efficient intramolecular asymmetric reductive amination transformation catalyzed by an iridium complex of tBu-ax-Josiphos has been realized, providing an efficient access to various THIQ alkaloids.

Highly efficient organic light-emitting diodes (OLEDs) based on an iridium complex with rigid cyclometalated ligand

2010 ◽  
Vol 11 (4) ◽  
pp. 632-640 ◽  
Author(s):  
Guanghui Zhang ◽  
Ho-Hsiu Chou ◽  
Xiaoqing Jiang ◽  
Peipei Sun ◽  
Chien-Hong Cheng ◽  
...  
Keyword(s):  
Light Emitting Diodes ◽  
Organic Light Emitting Diodes ◽  
Iridium Complex ◽  
Light Emitting ◽  
Highly Efficient ◽  
Organic Light ◽  
Cyclometalated Ligand

Highly efficient and solution-processed iridium complex for single-layer yellow electrophosphorescent diodes

2012 ◽  
Vol 22 (43) ◽  
pp. 23005 ◽  
Author(s):  
Xinhua Ouyang ◽  
Dongcheng Chen ◽  
Shuiming Zeng ◽  
Xingye Zhang ◽  
Shijian Su ◽  
...  
Keyword(s):  
Single Layer ◽  
Iridium Complex ◽  
Solution Processed ◽  
Highly Efficient

Copper-catalyzed radical cascade oxyalkylation of olefinic amides with simple alkanes: highly efficient access to benzoxazines

2017 ◽  
Vol 53 (56) ◽  
pp. 7961-7964 ◽  
Author(s):  
Jie Wang ◽  
Ruoyu Sang ◽  
Xiaolong Chong ◽  
Yinuo Zhao ◽  
Wenjie Fan ◽  
...  
Keyword(s):  
Bond Functionalization ◽  
Highly Efficient ◽  
Efficient Access ◽  
Radical Cascade

A copper-catalyzed C(sp3)–H bond functionalization of simple alkanes with olefinic amides was developed for the synthesis of benzoxazine derivatives.

scholarly journals Highly Efficient Access to Strained Bicyclic Ketals via Gold-Catalyzed Cycloisomerization of Bis-homopropargylic Diols.

ChemInform ◽  
2005 ◽  
Vol 36 (46) ◽  
Author(s):  
Sylvain Antoniotti ◽  
Emilie Genin ◽  
Veronique Michelet ◽  
Jean-Pierre Genet
Keyword(s):  
Highly Efficient ◽  
Efficient Access

Magnetic nanoparticle-supported phosphine gold(i) complex: a highly efficient and recyclable catalyst for the direct reductive amination of aldehydes and ketones

2016 ◽  
Vol 6 (12) ◽  
pp. 4554-4564 ◽  
Author(s):  
Weisen Yang ◽  
Li Wei ◽  
Feiyan Yi ◽  
Mingzhong Cai
Keyword(s):  
Magnetic Nanoparticle ◽  
Reductive Amination ◽  
Recyclable Catalyst ◽  
Highly Efficient ◽  
Aldehydes And Ketones ◽  
Supported Gold

The direct reductive amination of aldehydes and ketones has been achieved with excellent yields using recyclable magnetic nanoparticle-supported gold(i) catalyst.

scholarly journals Intramolecular asymmetric reductive amination: synthesis of enantioenriched dibenz[c,e]azepines

2019 ◽  
Vol 10 (8) ◽  
pp. 2473-2477 ◽  
Author(s):  
Tao Yang ◽  
Xiaochong Guo ◽  
Qin Yin ◽  
Xumu Zhang
Keyword(s):  
Reductive Amination ◽  
Enantioselective Synthesis ◽  
One Pot

An enantioselective synthesis of dibenz[c,e]azepines containing both central and axial chiralities through a one pot N-Boc deprotection/intramolecular asymmetric reductive amination sequence has been achieved with generally excellent enantiocontrol (up to 97% ee).

Intermetallic Ni2Si/SiCN as a highly efficient catalyst for the one-pot tandem synthesis of imines and secondary amines

2020 ◽  
Vol 7 (1) ◽  
pp. 82-90 ◽  
Author(s):  
Xiao Chen ◽  
Shuhua Han ◽  
Dongdong Yin ◽  
Changhai Liang
Keyword(s):  
High Activity ◽  
Aromatic Amine ◽  
Reductive Amination ◽  
High Selectivity ◽  
Secondary Amines ◽  
One Pot ◽  
Efficient Catalyst ◽  
Highly Efficient ◽  
The One ◽  
Tandem Synthesis

For the one-pot reductive amination of benzaldehyde with nitrobenzene, intermetallic Ni2Si/SiCN from the decomposition of a nickel-modified polysilazane precursor exhibited high activity (>99%) and high selectivity (92% to aromatic amine).

Enantioselective synthesis of pyrano[2,3-c]pyrrole via an organocatalytic [4 + 2] cyclization reaction of dioxopyrrolidines and azlactones

2019 ◽  
Vol 17 (16) ◽  
pp. 3945-3950 ◽  
Author(s):  
Yichen Wang ◽  
Yuzhen Chen ◽  
Xiaoping Li ◽  
Yukang Mao ◽  
Weiwen Chen ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Cyclization Reaction ◽  
Efficient Access

The present work provides a simple and efficient access to chiral pyrano[2,3-c]pyrrole via an asymmetric [4 + 2] cyclization reaction catalyzed by a cinchona-squaramide catalyst.

Intramolecular Michael Addition of N- and O-Centred Nucleophiles to Tethered Acrylates. The Role of Double-Bond Geometry in Controlling the Diastereo- selectivity of Cyclizations Leading to 2,6-Disubstituted Tetrahydropyrans and Piperidines.

1998 ◽  
Vol 51 (1) ◽  
pp. 9 ◽  
Author(s):  
Martin G. Banwell ◽  
Brett D. Bissett ◽  
Chinh T. Bui ◽  
Ha T. T. Pham ◽  
Gregory W. Simpson
Keyword(s):  
Double Bond ◽  
Total Synthesis ◽  
Michael Addition ◽  
Reductive Amination ◽  
Major Product ◽  
Enantioselective Synthesis ◽  
Cyclization Reactions ◽  
Glandular Secretion

The oxyanion derived from hydroxyacrylate E-(5) undergoes smooth intramolecular Michael addition to give the trans-2,6-disubstituted tetrahydropyran (7) as the major product of reaction. In contrast, the oxyanion obtained from isomer Z-(5) cyclizes to give the cis-2,6-disubstituted tetrahydropyran (6) as the major product. Such chemistry has been extended to the enantioselective synthesis of (+)-(6) the acquisition of which constitutes a formal total synthesis of acid (+)-(2), a constituent of the glandular secretion from the civet cat (Viverra civetta). Reductive amination of keto acrylate (12) affords an intermediate amine which cyclizes, in situ, to give the cis-2,6-disubstituted piperidine (26). Analogous treatment of compound (13) delivers the isomeric trans-2,6-disubstituted piperidine (27) as the exclusive product of reaction. Transition state structures have been proposed to account for the diastereoselectivities observed in all of the cyclization reactions.

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