Time Evolution of the Nanoparticle Protein Corona

ACS Nano ◽  
2010 ◽  
Vol 4 (7) ◽  
pp. 3623-3632 ◽  
Author(s):  
Eudald Casals ◽  
Tobias Pfaller ◽  
Albert Duschl ◽  
Gertie Janneke Oostingh ◽  
Victor Puntes
Keyword(s):  
Time Evolution ◽  
Protein Corona

scholarly journals Time-evolution of in vivo protein corona onto blood-circulating PEGylated liposomal doxorubicin (DOXIL) nanoparticles

Nanoscale ◽  
2016 ◽  
Vol 8 (13) ◽  
pp. 6948-6957 ◽  
Author(s):  
Marilena Hadjidemetriou ◽  
Zahraa Al-Ahmady ◽  
Kostas Kostarelos
Keyword(s):  
Time Evolution ◽  
Liposomal Doxorubicin ◽  
Pegylated Liposomal Doxorubicin ◽  
Protein Corona

Time evolution of β-lactoglobulin corona formation on gold nanoparticles and impact on allergy

2020 ◽  
Author(s):  
Xiaoning Zhang ◽  
Meifeng Li ◽  
Yuanping Lv ◽  
Xiaoling Sun ◽  
Yao Han ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Secondary Structure ◽  
Time Evolution ◽  
Electrostatic Force ◽  
Protein Corona ◽  
Raw Milk ◽  
Covalent Bonds ◽  
Corona Formation ◽  
Β Lactoglobulin ◽  
Β Sheet

Abstract Gold nanoparticles (AuNPs) are modified immediately by the adsorption of β-lactoglobulin (βlg) when designed as colorimetric probe in raw milk, leading to the formation of a protein corona. This adsorption results mainly from a fast electrostatic force and a slow formation of Au-S covalent bonds, which is a precondition for the use of AuNPs in biodetection. The proteins corona influences the structure and bioactivity of adsorbed protein, such as the allergy. In this study, the mechanism of βlg adsorbed on AuNPs was investigated in terms of stoichiometry, binding affinity (Ka), time evolution of Au-S bond, and general secondary structure changes to address the desensitization of AuNPs. The results show that about 3,600 βlg are adsorbed on a single AuNPs, and the Ka is 2.9 ± 0.7 × 10 6 M -1 . The formation of Au-S bonds takes about 9 h, which is the time needed for complete changes in secondary structure and the IgE combining capacity. The structure of allergenic epitopes assigned to β-sheet was destroyed by the formation of Au-S bond, then induced to the decrease allergy. Furthermore, Fourier transform infrared spectroscopy confirmed a decrease in β-sheet contents after conjugated with AuNPs.

scholarly journals Modeling the Time Evolution of the Nanoparticle-Protein Corona in a Body Fluid

PLoS ONE ◽  
2010 ◽  
Vol 5 (6) ◽  
pp. e10949 ◽  
Author(s):  
Daniele Dell'Orco ◽  
Martin Lundqvist ◽  
Cecilia Oslakovic ◽  
Tommy Cedervall ◽  
Sara Linse
Keyword(s):  
Time Evolution ◽  
Body Fluid ◽  
Protein Corona

Time evolution and dynamic cellular uptake of PEGYlated gold nanorods

RSC Advances ◽  
2016 ◽  
Vol 6 (10) ◽  
pp. 8089-8092 ◽  
Author(s):  
Hongyuan Song ◽  
Qingqiang Xu ◽  
Hongwei Di ◽  
Ting Guo ◽  
Zhongtian Qi ◽  
...  
Keyword(s):  
Time Evolution ◽  
Cellular Uptake ◽  
Gold Nanorods ◽  
Protein Corona

The protein corona formed and evolved of PEGYlated GNRs which alter GNRs characteristics significantly leading to dynamic cellular uptake pathways.

Time Evolution of Nanoparticle–Protein Corona in Human Plasma: Relevance for Targeted Drug Delivery

Langmuir ◽  
2013 ◽  
Vol 29 (21) ◽  
pp. 6485-6494 ◽  
Author(s):  
Ana Lilia Barrán-Berdón ◽  
Daniela Pozzi ◽  
Giulio Caracciolo ◽  
Anna Laura Capriotti ◽  
Giuseppe Caruso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Plasma ◽  
Time Evolution ◽  
Targeted Drug Delivery ◽  
Protein Corona ◽  
Targeted Drug

Impact of polymer shell on the formation and time evolution of nanoparticle–protein corona

2013 ◽  
Vol 104 ◽  
pp. 213-220 ◽  
Author(s):  
Kishore Natte ◽  
Jörg F. Friedrich ◽  
Sebastian Wohlrab ◽  
Jana Lutzki ◽  
Regine von Klitzing ◽  
...  
Keyword(s):  
Time Evolution ◽  
Protein Corona ◽  
Polymer Shell

A COMPARISON BETWEEN ZIRCON-RUTILE THERMOMETRY OF ECLOGITES: IMPLICATIONS FOR TEMPERATURE-TIME EVOLUTION OF THE NORTH QAIDAM UHP TERRANE, CHINA

2017 ◽  
Author(s):  
David Hernández-Uribe ◽  
◽  
Chris G. Mattinson ◽  
Owen K. Neill ◽  
Andrew Kylander-Clark ◽  
...  
Keyword(s):  
Time Evolution ◽  
The North ◽  
North Qaidam ◽  
Temperature Time
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