Hydrogen-Bonding Layer-by-Layer-Assembled Biodegradable Polymeric Micelles as Drug Delivery Vehicles from Surfaces

ACS Nano ◽  
2008 ◽  
Vol 2 (2) ◽  
pp. 386-392 ◽  
Author(s):  
Byeong-Su Kim ◽  
Sang Wook Park ◽  
Paula T. Hammond
Keyword(s):  
Drug Delivery ◽  
Hydrogen Bonding ◽  
Polymeric Micelles ◽  
Bonding Layer ◽  
Layer By Layer ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7735-7748 ◽  
Author(s):  
Jordan E. Read ◽  
Dong Luo ◽  
Tina T. Chowdhury ◽  
Rod J. Flower ◽  
Robin N. Poston ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Migration ◽  
Drug Release ◽  
Layer By Layer ◽  
Ros Production ◽  
Flow Conditions ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Migration Assays ◽  
In Cells

Magnetically responsive LbL microcapsules are biologically inert, magnetically retained in flow and cell migration assays so are retainable drug delivery vehicles.

ChemInform Abstract: Polymeric Micelles as Drug Delivery Vehicles

ChemInform ◽  
2014 ◽  
Vol 45 (36) ◽  
pp. no-no
Author(s):  
Zaheer Ahmad ◽  
Afzal Shah ◽  
Muhammad Siddiq ◽  
Heinz-Bernhard Kraatz
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Evaluation of polyanion-coated biodegradable polymeric micelles as drug delivery vehicles

2011 ◽  
Vol 155 (1) ◽  
pp. 104-110 ◽  
Author(s):  
Yuichi Ohya ◽  
Shinya Takeda ◽  
Yosuke Shibata ◽  
Tatsuro Ouchi ◽  
Arihiro Kano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Novel polymeric micelles as enzyme-sensitive nuclear-targeted dual-functional drug delivery vehicles for enhanced 9-nitro-20(S)-camptothecin delivery and antitumor efficacy

Nanoscale ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 5380-5396 ◽  
Author(s):  
Yalin Sun ◽  
Yan Liang ◽  
Na Hao ◽  
Xiaoheng Fu ◽  
Bin He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Polymeric Micelles ◽  
Antitumor Drug ◽  
Antitumor Efficacy ◽  
Drug Delivery Vehicles ◽  
Dual Functional ◽  
Delivery Vehicles

Antitumor drug 9-NC was loaded in the HA based micelles 9-NC/HATPC, which were targeted to tumor and dissociated into secondary micelles 9-NC/TPC in lysosomes in tumor cells and then it could delivery 9-NC directly to the cell “heart”.

Polymeric micelles as drug delivery vehicles

RSC Advances ◽  
2014 ◽  
Vol 4 (33) ◽  
pp. 17028-17038 ◽  
Author(s):  
Zaheer Ahmad ◽  
Afzal Shah ◽  
Muhammad Siddiq ◽  
Heinz-Bernhard Kraatz
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Hydrophobic Drugs ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Made In

Though much progress has been made in drug delivery systems, the design of a suitable carrier for the delivery of hydrophobic drugs is still a major challenge for researchers.

Dendrimers: General Aspects, Applications and Structural Exploitations as Prodrug/Drug-delivery Vehicles in Current Medicine

2018 ◽  
Vol 18 (5) ◽  
pp. 439-457 ◽  
Author(s):  
Merina Mariyam ◽  
Kajal Ghosal ◽  
Sabu Thomas ◽  
Nandakumar Kalarikkal ◽  
Mahima S. Latha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
General Aspects

Novel Phospholipid-Based Labrasol Nanomicelles Loaded Flavonoids for Oral Delivery with Enhanced Penetration and Anti-Brain Tumor Efficiency

2020 ◽  
Vol 17 (3) ◽  
pp. 229-245
Author(s):  
Gang Wang ◽  
Junjie Wang ◽  
Rui Guan
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Oral Delivery ◽  
Safe Delivery ◽  
Drug Delivery Vehicles ◽  
Therapeutic Benefits ◽  
Delivery Vehicles ◽  
The Brain

Background: Owing to the rich anticancer properties of flavonoids, there is a need for their incorporation into drug delivery vehicles like nanomicelles for safe delivery of the drug into the brain tumor microenvironment. Objective: This study, therefore, aimed to prepare the phospholipid-based Labrasol/Pluronic F68 modified nano micelles loaded with flavonoids (Nano-flavonoids) for the delivery of the drug to the target brain tumor. Methods: Myricetin, quercetin and fisetin were selected as the initial drugs to evaluate the biodistribution and acute toxicity of the drug delivery vehicles in rats with implanted C6 glioma tumors after oral administration, while the uptake, retention, release in human intestinal Caco-2 cells and the effect on the brain endothelial barrier were investigated in Human Brain Microvascular Endothelial Cells (HBMECs). Results: The results demonstrated that nano-flavonoids loaded with myricetin showed more evenly distributed targeting tissues and enhanced anti-tumor efficiency in vivo without significant cytotoxicity to Caco-2 cells and alteration in the Trans Epithelial Electric Resistance (TEER). There was no pathological evidence of renal, hepatic or other organs dysfunction after the administration of nanoflavonoids, which showed no significant influence on cytotoxicity to Caco-2 cells. Conclusion: In conclusion, Labrasol/F68-NMs loaded with MYR and quercetin could enhance antiglioma effect in vitro and in vivo, which may be better tools for medical therapy, while the pharmacokinetics and pharmacodynamics of nano-flavonoids may ensure optimal therapeutic benefits.

scholarly journals Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 427
Author(s):  
Amin Mirzaaghasi ◽  
Yunho Han ◽  
So-Hee Ahn ◽  
Chulhee Choi ◽  
Ji-Ho Park
Keyword(s):  
Drug Delivery ◽  
Therapeutic Potential ◽  
Hek293t Cell ◽  
Biological Properties ◽  
Context Analysis ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Diseased State ◽  
Sepsis And Septic Shock

Exosomes have attracted considerable attention as drug delivery vehicles because their biological properties can be utilized for selective delivery of therapeutic cargoes to disease sites. In this context, analysis of the in vivo behaviors of exosomes in a diseased state is required to maximize their therapeutic potential as drug delivery vehicles. In this study, we investigated biodistribution and pharmacokinetics of HEK293T cell-derived exosomes and PEGylated liposomes, their synthetic counterparts, into healthy and sepsis mice. We found that biodistribution and pharmacokinetics of exosomes were significantly affected by pathophysiological conditions of sepsis compared to those of liposomes. In the sepsis mice, a substantial number of exosomes were found in the lung after intravenous injection, and their prolonged blood residence was observed due to the liver dysfunction. However, liposomes did not show such sepsis-specific effects significantly. These results demonstrate that exosome-based therapeutics can be developed to manage sepsis and septic shock by virtue of their sepsis-specific in vivo behaviors.

scholarly journals Advances in Molecularly Imprinted Polymers as Drug Delivery Systems

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3589
Author(s):  
Rui Liu ◽  
Alessandro Poma
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymers ◽  
Drug Loading ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Drug Delivery Vehicles ◽  
The Past ◽  
Drug Molecules ◽  
Delivery Vehicles

Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localized and controlled drug delivery. Molecularly imprinted polymers (MIPs) as novel and versatile drug delivery vehicles have been widely studied in recent years due to the advantages of selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies undertaken for MIPs used as drug delivery vehicles involving different drug delivery mechanisms, such as rate-programmed, stimuli-responsive and active targeting, published during the course of the past five years.

Sign in / Sign up

Export Citation Format

Share Document