Novel polymeric micelles as enzyme-sensitive nuclear-targeted dual-functional drug delivery vehicles for enhanced 9-nitro-20(S)-camptothecin delivery and antitumor efficacy

Nanoscale ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 5380-5396 ◽  
Author(s):  
Yalin Sun ◽  
Yan Liang ◽  
Na Hao ◽  
Xiaoheng Fu ◽  
Bin He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Polymeric Micelles ◽  
Antitumor Drug ◽  
Antitumor Efficacy ◽  
Drug Delivery Vehicles ◽  
Dual Functional ◽  
Delivery Vehicles

Antitumor drug 9-NC was loaded in the HA based micelles 9-NC/HATPC, which were targeted to tumor and dissociated into secondary micelles 9-NC/TPC in lysosomes in tumor cells and then it could delivery 9-NC directly to the cell “heart”.

ChemInform Abstract: Polymeric Micelles as Drug Delivery Vehicles

ChemInform ◽  
2014 ◽  
Vol 45 (36) ◽  
pp. no-no
Author(s):  
Zaheer Ahmad ◽  
Afzal Shah ◽  
Muhammad Siddiq ◽  
Heinz-Bernhard Kraatz
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Evaluation of polyanion-coated biodegradable polymeric micelles as drug delivery vehicles

2011 ◽  
Vol 155 (1) ◽  
pp. 104-110 ◽  
Author(s):  
Yuichi Ohya ◽  
Shinya Takeda ◽  
Yosuke Shibata ◽  
Tatsuro Ouchi ◽  
Arihiro Kano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Patents in chemotherapy: nanoparticles as drug-delivery vehicles

2020 ◽  
Vol 9 (4) ◽  
pp. 117-119
Author(s):  
Absar Talat ◽  
Asad U Khan
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Advanced Technology ◽  
Drug Delivery Vehicles ◽  
The World ◽  
Delivery Vehicles ◽  
Novel Methods

The high statistics of cancer cases and mortalities throughout the world signify the urgent need for an advanced technology to target tumor cells. Nanotechnology has emerged as one such revolutionary platform to specifically target cancerous tissues and to enhance the efficacy for various anticancer drugs. This report is a snapshot of the patents in chemotherapy from January 2010 to May 2020 involving nanoparticles, novel methods developed for their synthesis and their impact as efficient drug-delivery vehicles.

Polymeric micelles as drug delivery vehicles

RSC Advances ◽  
2014 ◽  
Vol 4 (33) ◽  
pp. 17028-17038 ◽  
Author(s):  
Zaheer Ahmad ◽  
Afzal Shah ◽  
Muhammad Siddiq ◽  
Heinz-Bernhard Kraatz
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Hydrophobic Drugs ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Made In

Though much progress has been made in drug delivery systems, the design of a suitable carrier for the delivery of hydrophobic drugs is still a major challenge for researchers.

Dendrimers: General Aspects, Applications and Structural Exploitations as Prodrug/Drug-delivery Vehicles in Current Medicine

2018 ◽  
Vol 18 (5) ◽  
pp. 439-457 ◽  
Author(s):  
Merina Mariyam ◽  
Kajal Ghosal ◽  
Sabu Thomas ◽  
Nandakumar Kalarikkal ◽  
Mahima S. Latha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
General Aspects

Novel Phospholipid-Based Labrasol Nanomicelles Loaded Flavonoids for Oral Delivery with Enhanced Penetration and Anti-Brain Tumor Efficiency

2020 ◽  
Vol 17 (3) ◽  
pp. 229-245
Author(s):  
Gang Wang ◽  
Junjie Wang ◽  
Rui Guan
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Oral Delivery ◽  
Safe Delivery ◽  
Drug Delivery Vehicles ◽  
Therapeutic Benefits ◽  
Delivery Vehicles ◽  
The Brain

Background: Owing to the rich anticancer properties of flavonoids, there is a need for their incorporation into drug delivery vehicles like nanomicelles for safe delivery of the drug into the brain tumor microenvironment. Objective: This study, therefore, aimed to prepare the phospholipid-based Labrasol/Pluronic F68 modified nano micelles loaded with flavonoids (Nano-flavonoids) for the delivery of the drug to the target brain tumor. Methods: Myricetin, quercetin and fisetin were selected as the initial drugs to evaluate the biodistribution and acute toxicity of the drug delivery vehicles in rats with implanted C6 glioma tumors after oral administration, while the uptake, retention, release in human intestinal Caco-2 cells and the effect on the brain endothelial barrier were investigated in Human Brain Microvascular Endothelial Cells (HBMECs). Results: The results demonstrated that nano-flavonoids loaded with myricetin showed more evenly distributed targeting tissues and enhanced anti-tumor efficiency in vivo without significant cytotoxicity to Caco-2 cells and alteration in the Trans Epithelial Electric Resistance (TEER). There was no pathological evidence of renal, hepatic or other organs dysfunction after the administration of nanoflavonoids, which showed no significant influence on cytotoxicity to Caco-2 cells. Conclusion: In conclusion, Labrasol/F68-NMs loaded with MYR and quercetin could enhance antiglioma effect in vitro and in vivo, which may be better tools for medical therapy, while the pharmacokinetics and pharmacodynamics of nano-flavonoids may ensure optimal therapeutic benefits.

scholarly journals Biodistribution and Pharmacokinectics of Liposomes and Exosomes in a Mouse Model of Sepsis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 427
Author(s):  
Amin Mirzaaghasi ◽  
Yunho Han ◽  
So-Hee Ahn ◽  
Chulhee Choi ◽  
Ji-Ho Park
Keyword(s):  
Drug Delivery ◽  
Therapeutic Potential ◽  
Hek293t Cell ◽  
Biological Properties ◽  
Context Analysis ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Diseased State ◽  
Sepsis And Septic Shock

Exosomes have attracted considerable attention as drug delivery vehicles because their biological properties can be utilized for selective delivery of therapeutic cargoes to disease sites. In this context, analysis of the in vivo behaviors of exosomes in a diseased state is required to maximize their therapeutic potential as drug delivery vehicles. In this study, we investigated biodistribution and pharmacokinetics of HEK293T cell-derived exosomes and PEGylated liposomes, their synthetic counterparts, into healthy and sepsis mice. We found that biodistribution and pharmacokinetics of exosomes were significantly affected by pathophysiological conditions of sepsis compared to those of liposomes. In the sepsis mice, a substantial number of exosomes were found in the lung after intravenous injection, and their prolonged blood residence was observed due to the liver dysfunction. However, liposomes did not show such sepsis-specific effects significantly. These results demonstrate that exosome-based therapeutics can be developed to manage sepsis and septic shock by virtue of their sepsis-specific in vivo behaviors.

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