Skin Penetration and Cellular Uptake of Amorphous Silica Nanoparticles with Variable Size, Surface Functionalization, and Colloidal Stability

ACS Nano ◽  
2012 ◽  
Vol 6 (8) ◽  
pp. 6829-6842 ◽  
Author(s):  
Fiorenza Rancan ◽  
Qi Gao ◽  
Christina Graf ◽  
Stefan Troppens ◽  
Sabrina Hadam ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Cellular Uptake ◽  
Surface Functionalization ◽  
Amorphous Silica ◽  
Colloidal Stability ◽  
Skin Penetration ◽  
Variable Size

Surface Functionalization of Silica Nanoparticles Supports Colloidal Stability in Physiological Media and Facilitates Internalization in Cells

Langmuir ◽  
2012 ◽  
Vol 28 (20) ◽  
pp. 7598-7613 ◽  
Author(s):  
Christina Graf ◽  
Qi Gao ◽  
Irene Schütz ◽  
Christelle Njiki Noufele ◽  
Wentao Ruan ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Surface Functionalization ◽  
Colloidal Stability ◽  
In Cells

Cytotoxicity and Cellular Uptake of Amorphous Silica Nanoparticles in Human Cancer Cells

2015 ◽  
Vol 32 (7) ◽  
pp. 779-787 ◽  
Author(s):  
Yuequn Wu ◽  
Wei Tang ◽  
Peng Wang ◽  
Changsheng Liu ◽  
Yuan Yuan ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Amorphous Silica ◽  
Human Cancer ◽  
Human Cancer Cells

scholarly journals Drug-Loaded Polymeric Spherical Nucleic Acids: Enhancing Colloidal Stability and Cellular Uptake of Polymeric Nanoparticles through DNA Surface-Functionalization

2017 ◽  
Vol 18 (2) ◽  
pp. 483-489 ◽  
Author(s):  
Resham J. Banga ◽  
Sai Archana Krovi ◽  
Suguna P. Narayan ◽  
Anthony J. Sprangers ◽  
Guoliang Liu ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Cellular Uptake ◽  
Surface Functionalization ◽  
Colloidal Stability ◽  
Polymeric Nanoparticles ◽  
Spherical Nucleic Acids

scholarly journals The role of surface functionalization of silica nanoparticles for bioimaging

2016 ◽  
Vol 09 (04) ◽  
pp. 1630005 ◽  
Author(s):  
Maria C. Gomes ◽  
Ângela Cunha ◽  
Tito Trindade ◽  
João P. C. Tomé
Keyword(s):  
Silica Nanoparticles ◽  
Surface Functionalization ◽  
Colloidal Stability ◽  
Organic Dyes ◽  
Inorganic Nanoparticles ◽  
Biological Applications ◽  
Crucial Aspect ◽  
Particle Properties ◽  
Cellular Recognition

Among the several types of inorganic nanoparticles available, silica nanoparticles (SNP) have earned their relevance in biological applications namely, as bioimaging agents. In fact, fluorescent SNP (FSNP) have been explored in this field as protective nanocarriers, overcoming some limitations presented by conventional organic dyes such as high photobleaching rates. A crucial aspect on the use of fluorescent SNP relates to their surface properties, since it determines the extent of interaction between nanoparticles and biological systems, namely in terms of colloidal stability in water, cellular recognition and internalization, tracking, biodistribution and specificity, among others. Therefore, it is imperative to understand the mechanisms underlying the interaction between biosystems and the SNP surfaces, making surface functionalization a relevant step in order to take full advantage of particle properties. The versatility of the surface chemistry on silica platforms, together with the intrinsic hydrophilicity and biocompatibility, make these systems suitable for bioimaging applications, such as those mentioned in this review.

Fluorescent spherical mesoporous silica nanoparticles loaded with emodin: Synthesis, cellular uptake and anticancer activity

2021 ◽  
Vol 119 ◽  
pp. 111619
Author(s):  
Paul Jänicke ◽  
Claudia Lennicke ◽  
Annette Meister ◽  
Barbara Seliger ◽  
Ludger A. Wessjohann ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Anticancer Activity ◽  
Silica Nanoparticles ◽  
Cellular Uptake ◽  
Mesoporous Silica Nanoparticles

scholarly journals Insights on toxicity, safe handling and disposal of silica aerogels and amorphous nanoparticles

2021 ◽  
Author(s):  
João P. Vareda ◽  
Carlos A. García-González ◽  
Artur J. M. Valente ◽  
Rosana Simón-Vázquez ◽  
Marina Stipetic ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Amorphous Silica ◽  
Silica Aerogels ◽  
Safe Handling ◽  
Synthetic Amorphous Silica ◽  
Amorphous Nanoparticles

The toxicity and ecotoxicity effects, handling and disposal of synthetic amorphous silica nanoparticles and aerogels are reviewed and discussed.

Influence of Nanoparticle Shape, Size, and Surface Functionalization on Cellular Uptake

2013 ◽  
Vol 13 (10) ◽  
pp. 6485-6498 ◽  
Author(s):  
Ningning Ma ◽  
Chao Ma ◽  
Chuanyan Li ◽  
Ting Wang ◽  
Yongjun Tang ◽  
...  
Keyword(s):  
Cellular Uptake ◽  
Surface Functionalization ◽  
Nanoparticle Shape

Cellular internalization and stress response of ingested amorphous silica nanoparticles in the midgut of Drosophila melanogaster

2013 ◽  
Vol 1830 (1) ◽  
pp. 2256-2266 ◽  
Author(s):  
Ashutosh Pandey ◽  
Swati Chandra ◽  
Lalit Kumar Singh Chauhan ◽  
Gopeshwar Narayan ◽  
Debapratim Kar Chowdhuri
Keyword(s):  
Drosophila Melanogaster ◽  
Stress Response ◽  
Silica Nanoparticles ◽  
Amorphous Silica ◽  
Cellular Internalization
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