Surface Functionalization of Silica Nanoparticles Supports Colloidal Stability in Physiological Media and Facilitates Internalization in Cells

Langmuir ◽  
2012 ◽  
Vol 28 (20) ◽  
pp. 7598-7613 ◽  
Author(s):  
Christina Graf ◽  
Qi Gao ◽  
Irene Schütz ◽  
Christelle Njiki Noufele ◽  
Wentao Ruan ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Surface Functionalization ◽  
Colloidal Stability ◽  
In Cells

Skin Penetration and Cellular Uptake of Amorphous Silica Nanoparticles with Variable Size, Surface Functionalization, and Colloidal Stability

ACS Nano ◽  
2012 ◽  
Vol 6 (8) ◽  
pp. 6829-6842 ◽  
Author(s):  
Fiorenza Rancan ◽  
Qi Gao ◽  
Christina Graf ◽  
Stefan Troppens ◽  
Sabrina Hadam ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Cellular Uptake ◽  
Surface Functionalization ◽  
Amorphous Silica ◽  
Colloidal Stability ◽  
Skin Penetration ◽  
Variable Size

scholarly journals The role of surface functionalization of silica nanoparticles for bioimaging

2016 ◽  
Vol 09 (04) ◽  
pp. 1630005 ◽  
Author(s):  
Maria C. Gomes ◽  
Ângela Cunha ◽  
Tito Trindade ◽  
João P. C. Tomé
Keyword(s):  
Silica Nanoparticles ◽  
Surface Functionalization ◽  
Colloidal Stability ◽  
Organic Dyes ◽  
Inorganic Nanoparticles ◽  
Biological Applications ◽  
Crucial Aspect ◽  
Particle Properties ◽  
Cellular Recognition

Among the several types of inorganic nanoparticles available, silica nanoparticles (SNP) have earned their relevance in biological applications namely, as bioimaging agents. In fact, fluorescent SNP (FSNP) have been explored in this field as protective nanocarriers, overcoming some limitations presented by conventional organic dyes such as high photobleaching rates. A crucial aspect on the use of fluorescent SNP relates to their surface properties, since it determines the extent of interaction between nanoparticles and biological systems, namely in terms of colloidal stability in water, cellular recognition and internalization, tracking, biodistribution and specificity, among others. Therefore, it is imperative to understand the mechanisms underlying the interaction between biosystems and the SNP surfaces, making surface functionalization a relevant step in order to take full advantage of particle properties. The versatility of the surface chemistry on silica platforms, together with the intrinsic hydrophilicity and biocompatibility, make these systems suitable for bioimaging applications, such as those mentioned in this review.

Colloidal stability and degradability of silica nanoparticles in biological fluids: a review

2022 ◽  
Author(s):  
Andressa da Cruz Schneid ◽  
Lindomar Jose Calumby Albuquerque ◽  
Gabriela Borba Mondo ◽  
Marcelo Ceolin ◽  
Agustin Silvio Picco ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Colloidal Stability ◽  
Biological Fluids

Colloidal Stability and Redispersibility of Mesoporous Silica Nanoparticles in Biological Media

Langmuir ◽  
2020 ◽  
Vol 36 (39) ◽  
pp. 11442-11449 ◽  
Author(s):  
Andressa da Cruz Schneid ◽  
Camila Pedroso Silveira ◽  
Flávia Elisa Galdino ◽  
Larissa Fernanda Ferreira ◽  
Karim Bouchmella ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Colloidal Stability ◽  
Mesoporous Silica Nanoparticles ◽  
Biological Media

Versatile Route to Colloidal Stability and Surface Functionalization of Hydrophobic Nanomaterials

Langmuir ◽  
2016 ◽  
Vol 32 (22) ◽  
pp. 5629-5636 ◽  
Author(s):  
Heidi R. Culver ◽  
Stephanie D. Steichen ◽  
Margarita Herrera-Alonso ◽  
Nicholas A. Peppas
Keyword(s):  
Surface Functionalization ◽  
Colloidal Stability

PCR quantification of SiO2 particle uptake in cells in the ppb and ppm range via silica encapsulated DNA barcodes

2014 ◽  
Vol 50 (73) ◽  
pp. 10707-10709 ◽  
Author(s):  
Marcus Hoop ◽  
Daniela Paunescu ◽  
Philipp R. Stoessel ◽  
Fritz Eichenseher ◽  
Wendelin J. Stark ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Cellular Uptake ◽  
Dna Barcode ◽  
Dna Barcodes ◽  
Cell Level ◽  
Sio2 Particle ◽  
Particle Uptake ◽  
In Cells

The cellular uptake of silica nanoparticles loaded with a DNA barcode can be detected at a 10 fg per cell level utilizing qPCR analytics.

Surface−Atom Transfer Radical Polymerization from Silica Nanoparticles with Controlled Colloidal Stability

2004 ◽  
Vol 37 (17) ◽  
pp. 6376-6384 ◽  
Author(s):  
Abdeslam El Harrak ◽  
Géraldine Carrot ◽  
Julian Oberdisse ◽  
Christophe Eychenne-Baron ◽  
François Boué
Keyword(s):  
Atom Transfer Radical Polymerization ◽  
Silica Nanoparticles ◽  
Radical Polymerization ◽  
Colloidal Stability ◽  
Surface Atom ◽  
Atom Transfer
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