In Vivo Imaging of Carbon Nanotube Biodistribution Using Magnetic Resonance Imaging

Nano Letters ◽  
2009 ◽  
Vol 9 (3) ◽  
pp. 1023-1027 ◽  
Author(s):  
Achraf Al Faraj ◽  
Katarzyna Cieslar ◽  
Ghislaine Lacroix ◽  
Sophie Gaillard ◽  
Emmanuelle Canet-Soulas ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Carbon Nanotube ◽  
Magnetic Resonance ◽  
In Vivo Imaging ◽  
Resonance Imaging

scholarly journals Cellular Magnetic Resonance Imaging: In Vivo Imaging of Melanoma Cells in Lymph Nodes of Mice

Neoplasia ◽  
2008 ◽  
Vol 10 (3) ◽  
pp. 207-216 ◽  
Author(s):  
Paula J Foster ◽  
Elizabeth A Dunn ◽  
Kristina E Karl ◽  
Jonatan A Snir ◽  
Colleen M Nycz ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Lymph Nodes ◽  
In Vivo Imaging ◽  
Melanoma Cells ◽  
Resonance Imaging

scholarly journals In Vivo Imaging of Tau Pathology Using Magnetic Resonance Imaging Textural Analysis

2017 ◽  
Vol 11 ◽  
Author(s):  
Niall Colgan ◽  
Balaji Ganeshan ◽  
Ian F. Harrison ◽  
Ozama Ismail ◽  
Holly E. Holmes ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
In Vivo Imaging ◽  
Textural Analysis ◽  
Resonance Imaging ◽  
Tau Pathology

scholarly journals In Vivo Imaging of Immuno-Spin Trapped Radicals With Molecular Magnetic Resonance Imaging in a Diabetic Mouse Model

Diabetes ◽  
2012 ◽  
Vol 61 (10) ◽  
pp. 2405-2413 ◽  
Author(s):  
R. A. Towner ◽  
N. Smith ◽  
D. Saunders ◽  
M. Henderson ◽  
K. Downum ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mouse Model ◽  
In Vivo Imaging ◽  
Diabetic Mouse ◽  
Resonance Imaging

Targeting Peritumoral Lesions Identified by Computed Tomography and Magnetic Resonance Imaging in Feline Injection-Site Sarcomas for Microscopic Examination

2021 ◽  
pp. 030098582110129
Author(s):  
Christiane V. Löhr ◽  
Susanne M. Stieger-Vanegas ◽  
Jesse L. Terry ◽  
Milan Milovancev ◽  
Jan Medlock
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Injection Site ◽  
Microscopic Examination ◽  
In Vivo Imaging ◽  
Surgical Margins ◽  
Surrounding Tissue ◽  
Resonance Imaging

Peritumoral lesions identified during in vivo imaging of feline injection-site sarcoma (FISS) are frequently interpreted as neoplastic. We recently showed that most peritumoral imaging-identified lesions (PTIILs) in FISS are non-neoplastic. In this article, we describe a protocol to target PTIIL for microscopic examination and report on the protocol’s performance. Ten client-owned cats with FISS were prospectively enrolled. A fiducial marker sutured onto the skin, centered on the palpable mass, served as reference point throughout the study. Each FISS and surrounding tissue was imaged in vivo by dual phase computed tomography angiography and multiple magnetic resonance imaging pulse sequences and each PTIIL documented. Subgross measurements obtained during trimming aided localization and identification of PTIIL during microscopy. Histologic findings were categorized by descending clinical relevance: neoplastic, equivocal, non-neoplastic, within normal limits (WNL). Based on in vivo imaging resolution limits, histologic findings were ≥3 mm in at least one dimension and ≥3 mm apart. Surgical margins served as control tissue for PTIILs. Eighty-one of 87 PTIIL were examined histologically; 13 were neoplastic, 16 equivocal, and 28 non-neoplastic; 24 had no identified histologic correlate. Two neoplastic and 10 equivocal findings were located outside of PTIILs but none of them were located in sections of surgical margins. Computation of a simple confusion matrix yielded fair sensitivity (70.4%) and low specificity (59.7%) for prediction of PTIIL by histologic findings. After combining instances of normal microanatomy with non-neoplastic histologic findings, specificity increased (85.1%) and sensitivity decreased (35.8%). The protocol is a blueprint for targeting PTIIL for microscopic examination but may benefit from further refinement.

New Enzyme-Activated Solubility-Switchable Contrast Agent for Magnetic Resonance Imaging: From Synthesis to in Vivo Imaging

2009 ◽  
Vol 52 (6) ◽  
pp. 1576-1581 ◽  
Author(s):  
Beata Jastrzȩbska ◽  
Réjean Lebel ◽  
Hélène Therriault ◽  
J. Oliver McIntyre ◽  
Emanuel Escher ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
In Vivo Imaging ◽  
Resonance Imaging

scholarly journals Rational Constructed Ultra-Small Iron Oxide Nanoprobes Manifesting High Performance for T1-weighted Magnetic Resonance Imaging of Glioblastoma

Nanomaterials ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2601
Author(s):  
Xiangyan Wang ◽  
Lei Chen ◽  
Jianxian Ge ◽  
Mohammad Javad Afshari ◽  
Lei Yang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
In Vivo Imaging ◽  
High Performance ◽  
Enhancement Effect ◽  
Resonance Imaging ◽  
Glioblastoma Cells ◽  
Imaging Results

Precise diagnosis and monitoring of cancer depend on the development of advanced technologies for in vivo imaging. Owing to the merits of outstanding spatial resolution and excellent soft-tissue contrast, the application of magnetic resonance imaging (MRI) in biomedicine is of great importance. Herein, Angiopep-2 (ANG), which can simultaneously help to cross the blood-brain barrier and target the glioblastoma cells, was rationally combined with the 3.3 nm-sized ultra-small iron oxide (Fe3O4) to construct high-performance MRI nanoprobes (Fe3O4-ANG NPs) for glioblastoma diagnosis. The in vitro experiments show that the resultant Fe3O4-ANG NPs not only exhibit favorable relaxation properties and colloidal stability, but also have low toxicity and high specificity to glioblastoma cells, which provide critical prerequisites for the in vivo tumor imaging. Furthermore, in vivo imaging results show that the Fe3O4-ANG NPs exhibit good targeting ability toward subcutaneous and orthotopic glioblastoma model, manifesting an obvious contrast enhancement effect on the T1-weighted MR image, which demonstrates promising potential in clinical application.

scholarly journals In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging

2021 ◽  
Author(s):  
Shuangyang Zhang ◽  
Li Qi ◽  
Xipan Li ◽  
Zhichao Liang ◽  
Jian Wu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Soft Tissue ◽  
In Vivo Imaging ◽  
Molecular Probe ◽  
Photoacoustic Tomography ◽  
Resonance Imaging ◽  
Dual Modality ◽  
Wide Range

AbstractMagnetic resonance imaging (MRI) and photoacoustic tomography (PAT) are two advanced imaging modalities that offer two distinct image contrasts: MRI has a multi-parameter contrast mechanism that provides excellent anatomical soft tissue contrast, whereas PAT is capable of mapping tissue physiological metabolism and exogenous contrast agents with optical specificity. Attempts have been made to integrate these two modalities, but rigid and reliable registration of the images for in vivo imaging is still challenging. In this paper, we present a complete hardware-software solution for the successive acquisition and co-registration of PAT and MRI images in in vivo animal studies. Based on commercial PAT and MRI scanners, our solution includes a 3D-printed dual-modality animal imaging bed, a 3-D spatial image co-registration algorithm with bi-model markers, and a robust modality switching protocol for in vivo imaging studies. Using the proposed solution, we successfully demonstrated co-registered hybrid-contrast PAT-MRI imaging that simultaneously display multi-scale anatomical, functional and molecular characteristics on healthy and cancerous living mice. Week-long longitudinal dual-modality imaging of tumor development reveals information on size, border, vascular pattern, blood oxygenation, and molecular probe metabolism of the tumor micro-environment at the same time. Additionally, by incorporating soft-tissue information in the co-registered MRI image, we further show that PAT image quality could be enhanced by MRI-guided light fluence correction. The proposed methodology holds the promise for a wide range of pre-clinical research applications that benefit from the PAT-MRI dual-modality image contrast.

Sign in / Sign up

Export Citation Format

Share Document