New Enzyme-Activated Solubility-Switchable Contrast Agent for Magnetic Resonance Imaging: From Synthesis to in Vivo Imaging

2009 ◽  
Vol 52 (6) ◽  
pp. 1576-1581 ◽  
Author(s):  
Beata Jastrzȩbska ◽  
Réjean Lebel ◽  
Hélène Therriault ◽  
J. Oliver McIntyre ◽  
Emanuel Escher ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
In Vivo Imaging ◽  
Resonance Imaging

scholarly journals Silica-Coated Fe3O4 Nanoparticles as a Bifunctional Agent for Magnetic Resonance Imaging and ZnII Fluorescent Sensing

2021 ◽  
Vol 20 ◽  
pp. 153303382110365
Author(s):  
Lin Qiu ◽  
Shuwen Zhou ◽  
Ying Li ◽  
Wen Rui ◽  
Pengfei Cui ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Quantum Interference ◽  
Inductively Coupled Plasma ◽  
Fluorescence Emission ◽  
Mri Contrast Agent ◽  
Core Shell ◽  
Resonance Imaging

Bifunctional magnetic/fluorescent core-shell silica nanospheres (MNPs) encapsulated with the magnetic Fe3O4 core and a derivate of 8-amimoquinoline (N-(quinolin-8-yl)-2-(3-(triethoxysilyl) propylamino) acetamide) (QTEPA) into the shell were synthesized. These functional MNPs were prepared with a modified stöber method and the formed Fe3O4@SiO2-QTEPA core-shell nanocomposites are biocompatible, water-dispersible, and stable. These prepared nanoparticles were characterized by X-ray power diffraction (XRD), transmission electron microscopy (TEM), thermoelectric plasma Quad II inductively coupled plasma mass spectrometry (ICP-MS), superconducting quantum interference device (SQUID), TG/DTA thermal analyzer (TGA) and Fourier transform infrared spectroscopy (FTIR). Further application of the nanoparticles in detecting Zn2+ was confirmed by the fluorescence experiment: the nanosensor shows high selectivity and sensitivity to Zn2+ with a 22-fold fluorescence emission enhancement in the presence of 10 μM Zn2+. Moreover, the transverse relaxivity measurements show that the core-shell MNPs have T2 relaxivity (r2) of 155.05 mM−1 S−1 based on Fe concentration on the 3.0 T scanner, suggesting that the compound can be used as a negative contrast agent for MRI. Further in vivo experiments showed that these MNPs could be used as MRI contrast agent. Therefore, the new nanosensor provides the dual modality of magnetic resonance imaging and optical imaging.

scholarly journals Monitoring ferumoxide-labelled neural progenitor cells and lesion evolution by magnetic resonance imaging in a model of cell transplantation in cerebral ischaemia

F1000Research ◽  
2014 ◽  
Vol 2 ◽  
pp. 252
Author(s):  
Rachael A Panizzo ◽  
David G Gadian ◽  
Jane C Sowden ◽  
Jack A Wells ◽  
Mark F Lythgoe ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Cerebral Ischaemia ◽  
Mri Contrast Agent ◽  
Lesion Volume ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Protamine Sulphate

Efficacy of neural stem/progenitor cell (NPC) therapies after cerebral ischaemia could be better evaluated by monitoring in vivo migration and distribution of cells post-engraftment in parallel with analysis of lesion volume and functional recovery. Magnetic resonance imaging (MRI) is ideally placed to achieve this, but still poses several challenges. We show that combining the ferumoxide MRI contrast agent Endorem with protamine sulphate (FePro) improves iron oxide uptake in cells compared to Endorem alone and is non-toxic. Hence FePro complex is a better contrast agent than Endorem for monitoring NPCs. FePro complex-labelled NPCs proliferated and differentiated normally in vitro, and upon grafting into the brain 48 hours post-ischaemia they were detected in vivo by MRI. Imaging over four weeks showed the development of a confounding endogenous hypointense contrast evolution at later timepoints within the lesioned tissue. This was at least partly due to accumulation within the lesion of macrophages and endogenous iron. Neither significant NPC migration, assessed by MRI and histologically, nor a reduction in the ischaemic lesion volume was observed in NPC-grafted brains.  Crucially, while MRI provides reliable information on engrafted cell location early after an ischaemic insult, pathophysiological changes to ischaemic lesions can interfere with cellular imaging at later timepoints.

scholarly journals Cellular Magnetic Resonance Imaging: In Vivo Imaging of Melanoma Cells in Lymph Nodes of Mice

Neoplasia ◽  
2008 ◽  
Vol 10 (3) ◽  
pp. 207-216 ◽  
Author(s):  
Paula J Foster ◽  
Elizabeth A Dunn ◽  
Kristina E Karl ◽  
Jonatan A Snir ◽  
Colleen M Nycz ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Lymph Nodes ◽  
In Vivo Imaging ◽  
Melanoma Cells ◽  
Resonance Imaging

Experimental Otitis Media Evaluated by Magnetic Resonance Imaging: An in Vivo Model

1992 ◽  
Vol 101 (3) ◽  
pp. 248-254 ◽  
Author(s):  
Kenny H. Chan ◽  
William J. Doyle ◽  
J. Douglas Swarts ◽  
David Kardatzke ◽  
Yoshie Hashida ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Otitis Media ◽  
Middle Ear ◽  
Washout Rate ◽  
In Vivo Model ◽  
Resonance Imaging ◽  
Middle Ear Mucosa

The use of magnetic resonance imaging in otitis media research is being explored in our laboratory. In this study, we present a new method for studying changes in the middle ear cleft due to an episode of induced otitis media in the chinchilla model. It uses gadolinium-diethylenetriamine pentaacetic acid, a magnetic resonance imaging contrast agent, to examine the uptake and washout characteristics of middle ear mucosa during an inflammatory episode. Parameters such as the time to maximum intensity of the mucosa and the washout rate of the contrast agent from the mucosa were significantly correlated to the duration of the infection.

scholarly journals Chronic Thrombus Detection With In Vivo Magnetic Resonance Imaging and a Fibrin-Targeted Contrast Agent

Circulation ◽  
2005 ◽  
Vol 112 (11) ◽  
pp. 1594-1600 ◽  
Author(s):  
Marc Sirol ◽  
Valentin Fuster ◽  
Juan J. Badimon ◽  
John T. Fallon ◽  
Jean-François Toussaint ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Targeted Contrast Agent

scholarly journals In Vivo Imaging of Tau Pathology Using Magnetic Resonance Imaging Textural Analysis

2017 ◽  
Vol 11 ◽  
Author(s):  
Niall Colgan ◽  
Balaji Ganeshan ◽  
Ian F. Harrison ◽  
Ozama Ismail ◽  
Holly E. Holmes ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
In Vivo Imaging ◽  
Textural Analysis ◽  
Resonance Imaging ◽  
Tau Pathology

Hyperbranched poly(glycerol) as a T1 contrast agent for tumor-targeted magnetic resonance imaging in vivo

2017 ◽  
Vol 8 (6) ◽  
pp. 1104-1113 ◽  
Author(s):  
Yi Cao ◽  
Min Liu ◽  
Guangyue Zu ◽  
Ye Kuang ◽  
Xiaoyan Tong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Folic Acid ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
One Pot ◽  
Hyperbranched Poly ◽  
T1 Contrast Agent ◽  
T1 Contrast

To explore a convenient and efficient strategy for constructing tumor-targeted T1 mCAs for MRI, hyperbranched poly(glycerol) prepared in one-pot was used to conjugate gadolinium chelates and folic acid ligands through “click chemistry”.

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