Lectin Conjugated Gastroretentive Multiparticulate Delivery System of Clarithromycin for the Effective Treatment of Helicobacter pylori

2008 ◽  
Vol 6 (1) ◽  
pp. 295-304 ◽  
Author(s):  
Sunil K. Jain ◽  
Manmohan S. Jangdey
Keyword(s):  
Helicobacter Pylori ◽  
Effective Treatment ◽  
Delivery System

PHA-Based Thermogel as a Controlled Zero-Order Chemotherapeutic Delivery System for the Effective Treatment of Melanoma

2019 ◽  
Vol 2 (8) ◽  
pp. 3591-3600 ◽  
Author(s):  
Lu Jiang ◽  
Zheng Luo ◽  
Xian Jun Loh ◽  
Yun-Long Wu ◽  
Zibiao Li
Keyword(s):  
Effective Treatment ◽  
Delivery System ◽  
Zero Order ◽  
Chemotherapeutic Delivery

Nanoscale delivery systems in treatment of posterior ocular neovascularization: strategies and potential applications

2019 ◽  
Vol 10 (11) ◽  
pp. 737-747 ◽  
Author(s):  
Priyanka Bhatt ◽  
Shannon Kelly ◽  
Vijaykumar Sutariya
Keyword(s):  
Effective Treatment ◽  
Delivery System ◽  
Pharmacological Treatment ◽  
Vision Loss ◽  
Delivery Systems ◽  
Posterior Segment ◽  
Special Report ◽  
Main Obstacle ◽  
Ocular Neovascularization ◽  
Potential Applications

Pathologic posterior neovascularization of eye is a major cause of irreversible vision loss and limitations of therapeutics to be successfully delivered to back of the eye has been a main obstacle for its effective treatment. Current pharmacological treatment using anti-VEGF agents being delivered intravitreally are effective but complicated due to anatomical and physiological barriers, as well as administration of high and frequent doses. With expanding horizons of nanotechnology, it can be possible to formulate promising nanoscale delivery system to improve penetration and sustained the release of therapeutic in posterior segment of the eye. Taking into consideration advances in the field of nanoscale delivery systems, this special report focuses on emerging strategies and their applications for treatment of posterior ocular neovascularization.

scholarly journals Controlled Delayed Cooling Extends Peach Market Life

2004 ◽  
Vol 14 (1) ◽  
pp. 99-104 ◽  
Author(s):  
Carlos H. Crisosto ◽  
David Garner ◽  
Harry L. Andris ◽  
Kevin R. Day
Keyword(s):  
Weight Loss ◽  
Effective Treatment ◽  
Delivery System ◽  
Fruit Quality ◽  
Prunus Persica ◽  
Quality Changes ◽  
Rapid Cooling ◽  
Cooling Period

A commercial controlled delayed cooling or preconditioning treatment was developed to extend peach (Prunus persica) market life of the most popular California peach cultivars. A 24 to 48 h cooling delay at 68 °F (20.0 °C) was the most effective treatment for extending market life of internal breakdown susceptible peaches without causing fruit deterioration. This treatment increased minimum market life by up to 2 weeks in the cultivars tested. Weight loss and softening occurred during the controlled delayed cooling treatments, but did not reduce fruit quality. Detailed monitoring of these fruit quality changes during the delayed cooling period and proper use of fungicides is highly recommended for success in this new fruit delivery system. Rapid cooling after preconditioning is important to stop further fruit deterioration such as flesh softening, senescence, decay and weight loss. Controlled delayed cooling can also be used to pre-ripen susceptible and nonsusceptible peaches to deliver a ready-to-buy product to the consumer.

scholarly journals High Primary Antibiotic Resistance of Helicobacter pylori Strains Isolated from Pediatric and Adult Patients in Poland during 2016–2018

Antibiotics ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 228
Author(s):  
Paweł Krzyżek ◽  
Dorota Pawełka ◽  
Barbara Iwańczak ◽  
Radosław Kempiński ◽  
Konrad Leśniakowski ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Antibiotic Resistance ◽  
Antimicrobial Resistance ◽  
Effective Treatment ◽  
Adult Patients ◽  
Minimum Inhibitory Concentrations ◽  
Treatment Naïve ◽  
Resistant Strains ◽  
H Pylori ◽  
High Level

Monitoring the antibiotic resistance of H. pylori is an important step in the effective treatment of this bacterium, thus the aim of the present study was to assess the prevalence of antimicrobial resistance of H. pylori strains isolated from pediatric and adult patients with primary infections in 2016–2018. Antral biopsies from 334 treatment-naïve patients (126 children and 208 adults) were obtained. A total of 71 clinical H. pylori strains (22 from children and 49 from adults) were isolated and examined for amoxicillin (AMX), clarithromycin (CLR), metronidazole (MTZ), tetracycline (TET), and levofloxacin (LEV) susceptibility. The activity of the antibiotics was measured by E-tests. Strains were considered as resistant to antibiotics with minimum inhibitory concentrations (MICs) equal to ≥0.125 μg/mL (AMX), ≥0.5 μg/mL (CLR), ≥8 μg/mL (MTZ), and ≥1 μg/mL (TET and LEV). The highest prevalence of antibiotic resistance in H. pylori strains was observed for CLR and MTZ, at frequencies of 54.5% and 31.8% vs. 30.6% and 46.9% for children and adults, respectively. A much lower frequency of isolation of resistant strains was demonstrated for LEV and TET, this being 9.1% and 4.5% vs. 18.4% and 4.1% for pediatric and adult patients, respectively. The presence of AMX-resistant strains was not observed. The H. pylori strains isolated from Polish patients with primary infections showed a high level of antibiotic resistance to CLR and MTZ (>30%).

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