scholarly journals Stomach-Site Specific Drug Delivery System of Clarithromycin for Eradication of Helicobacter pylori

2009 ◽  
Vol 57 (10) ◽  
pp. 1068-1075 ◽  
Author(s):  
Paruvathanahalli Siddalingam Rajinikanth ◽  
Brahmeshwar Mishra
Keyword(s):  
Drug Delivery ◽  
Helicobacter Pylori ◽  
Drug Delivery System ◽  
Delivery System ◽  
Specific Drug ◽  
Site Specific

A comprehensive review on microbubble concept, development and its application in therapeutics drug delivery and clinical management of disease

2020 ◽  
Vol 21 ◽  
Author(s):  
Sandeep Rathor ◽  
Sheikh Aamir ◽  
D.C. Bhatt ◽  
Krishan Kumar ◽  
Vikash Kumar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Clinical Management ◽  
Genetic Material ◽  
Specific Drug ◽  
Site Specific ◽  
Floating Drug Delivery ◽  
Biomedical Field ◽  
Gastro Retentive

Background:: The general purpose of this review was to briefly describe the gastro-retentive drug delivery system (GRDDS) and primary focuses on mechanisms of flotation for gastric retention. The principle mechanism of floating drug delivery systems (FDDS) is mainly based on hydro-dynamically controlled low-density system which gets swollen when come in contact with gastric environment and remain buoyant for extended period of time with improved bioavailability and therapeutic efficacy. The main perspective of this review was to focus on microbubble drug delivery due to its wide range of application. Microbubble is a new, economically viable and non-invasive technique which is alternative to conventional techniques. The size of microbubble ranges from 1-100 micrometers which contain oxygen or air and remain suspended for prolonged drug release. Due to its great potential microbubble is used in therapeutic delivery of drug molecule or genetic material at their specific targeted site in various diseases. The recent research also suggests that ultrasound mediated microbubble is more frequently used in biomedical field for imaging of site-specific molecule targeting for detection of disease and site-specific drug delivery. Conclusion:: Gastro-retentive floating drug delivery system was considered as most favorable approach for site-specific drug delivery. But nowadays, microbubble is gaining more popularity for its potential application in biomedical field. In recent years, there is much progress in microbubble for site specific delivery of drug or genetic material. Recent research also suggests that the ultrasound mediated microbubble have shown positive impact in the diagnosis and clinical management of various diseases such as Liver Cirrhosis, brain tumor, ocular and urinary tract infection.

scholarly journals A review on gastroretentive drug delivery system

2016 ◽  
Vol 4 (2) ◽  
pp. 01-10
Author(s):  
Shailaja Pant ◽  
Ashutosh Badola ◽  
Preeti Kothiyal
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Specific Drug ◽  
Site Specific ◽  
Gastric Residence Time ◽  
Gastro Intestinal Tract ◽  
Novel Drug ◽  
Absorption Window ◽  
Gastro Retentive

Oral controlled release and site specific drug delivery system has been of great interest in pharmaceutical field to achieve improved therapeutic advantage. Concept of novel drug delivery system arose to overcome certain aspect related to physicochemical properties of drug molecule and the related formulations. Gastro retentive drug delivery system is one of such novel approaches to prolong gastric residence time, thereby targeting site specific drug release in the stomach for local or systemic effects. This approach is useful particularly for the drugs which have narrow absorption window in the upper part of gastro intestinal tract. In this review we have been discussed various approaches of gastro retentive drug delivery system, such as floating and non-floating systems.

Treatment of intracoronary thrombus with local urokinase infusion using a new, site-specific drug delivery system: The Dispatch™ catheter

1994 ◽  
Vol 33 (2) ◽  
pp. 181-188 ◽  
Author(s):  
Raymond G. McKay ◽  
Daniel B. Fram ◽  
Jeffrey A. Hirst ◽  
Francis J. Kiernan ◽  
Charles A. Primiano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Specific Drug ◽  
Site Specific ◽  
Urokinase Infusion
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