The Role of Polymer Concentration on the Molecular Mobility and Physical Stability of Nifedipine Solid Dispersions

2015 ◽  
Vol 12 (5) ◽  
pp. 1477-1484 ◽  
Author(s):  
Khushboo Kothari ◽  
Vishard Ragoonanan ◽  
Raj Suryanarayanan
Keyword(s):  
Molecular Mobility ◽  
Solid Dispersions ◽  
Polymer Concentration ◽  
Physical Stability

scholarly journals Applications of Dynamic Mechanical Analysis in the Engineering of Amorphous Solid Dispersions

2020 ◽  
Vol 02 (01) ◽  
pp. e55-e63
Author(s):  
Andrew Toye Ojo ◽  
Ping I. Lee
Keyword(s):  
Molecular Mobility ◽  
Solid Dispersions ◽  
Physical Stability ◽  
Amorphous Solid ◽  
Mechanical Analysis ◽  
Water Soluble ◽  
Amorphous Solid Dispersions ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

AbstractDynamic mechanical analysis (DMA) offers several advantages over prevailing methods in the characterization of amorphous solid dispersions (ASDs) typically used for improving the delivery of poorly water-soluble drugs. This method of analysis, though underutilized in the study of pharmaceutical systems, is particularly attuned to rheological investigations of thermal and mechanical properties of solids such as ASDs. Its ability to determine the viscoelastic properties of systems across a wide range of temperatures and shear conditions provides useful insight for the development and processing of ASDs. The response of materials to an imposed stress, captured by DMA, can help identify proper conditions for preparing homogenous extrudates of the polymer and active pharmaceutical ingredient through hot melt extrusion (HME). As HME continues to gain utility within the pharmaceutical industry, the ability to tailor process conditions will become increasingly important for the efficient design and production of ASD products for poorly water-soluble drugs. Furthermore, DMA can be used to probe molecular mobility and its link to physical stability of ASDs. Establishing the link between molecular mobility and crystallization kinetics is central to predicting the physical stability of ASDs. Therefore, increasing the understanding of material properties through DMA will enable the successful development of more stable amorphous drug products. This review summarizes current characterization tools for ASDs and discusses the potential of utilizing DMA as a robust alternative to traditional methods.

Physical Stability of the Amorphous Anticholesterol Agent (Ezetimibe): The Role of Molecular Mobility

2014 ◽  
Vol 11 (11) ◽  
pp. 4280-4290 ◽  
Author(s):  
J. Knapik ◽  
Z. Wojnarowska ◽  
K. Grzybowska ◽  
L. Hawelek ◽  
W. Sawicki ◽  
...  
Keyword(s):  
Molecular Mobility ◽  
Physical Stability

Mechanism of Amorphous Itraconazole Stabilization in Polymer Solid Dispersions: Role of Molecular Mobility

2014 ◽  
Vol 11 (11) ◽  
pp. 4228-4237 ◽  
Author(s):  
Sunny P. Bhardwaj ◽  
Kapildev K. Arora ◽  
Elizabeth Kwong ◽  
Allen Templeton ◽  
Sophie-Dorothee Clas ◽  
...  
Keyword(s):  
Molecular Mobility ◽  
Solid Dispersions

Role of the Strength of Drug–Polymer Interactions on the Molecular Mobility and Crystallization Inhibition in Ketoconazole Solid Dispersions

2015 ◽  
Vol 12 (9) ◽  
pp. 3339-3350 ◽  
Author(s):  
Pinal Mistry ◽  
Sarat Mohapatra ◽  
Tata Gopinath ◽  
Frederick G. Vogt ◽  
Raj Suryanarayanan
Keyword(s):  
Molecular Mobility ◽  
Solid Dispersions ◽  
Crystallization Inhibition ◽  
Polymer Interactions

Influence of β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin on Enhancement of Solubility and Dissolution of Isradipine

2017 ◽  
Vol 10 (3) ◽  
pp. 3752-3757
Author(s):  
Narendar D ◽  
Ettireddy S
Keyword(s):  
Inclusion Complex ◽  
Dissolution Rate ◽  
Solid Dispersions ◽  
Physical Stability ◽  
Molecular Complexes ◽  
In Vitro Dissolution ◽  
Molar Ratio ◽  
Phase Solubility ◽  
Cyclodextrin Complexation

The content of this investigation was to study the influence of β-cyclodextrin and hydroxy propyl-β-cyclodextrin complexation on enhancement of solubility and dissolution rate of isradipine. Based on preliminary phase solubility studies, solid complexes prepared by freeze drying method in 1:1 molar ratio were selected and characterized by DSC for confirmation of complex formation. Prepared solid dispersions were evaluated for drug content, solubility and in vitro dissolution. The physical stability of optimized formulation was studied at refrigerated and room temperature for 2 months. Solid state characterization of optimized complex performed by DSC and XRD studies.  Dissolution rate of isradipine was increased compared with pure drug and more with HP-β-CD inclusion complex than β-CD. DSC and XRD analyzes that drug was in amorphous form, when the drug was incorporated as isradipine β-CD and HP-β-CD inclusion complex. Stability studies resulted in low or no variations in the percentage of complexation efficiency suggesting good stability of molecular complexes. The results conclusively demonstrated that the enhancement of solubility and dissolution rate of isradipine by drug-cyclodextrin complexation was achieved.   

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