Physical Stability and Solubility Advantage from Amorphous Celecoxib:  The Role of Thermodynamic Quantities and Molecular Mobility

2004 ◽  
Vol 1 (6) ◽  
pp. 406-413 ◽  
Author(s):  
Piyush Gupta ◽  
Garima Chawla ◽  
Arvind K. Bansal
Keyword(s):  
Molecular Mobility ◽  
Physical Stability ◽  
Thermodynamic Quantities

Physical Stability of Amorphous Pharmaceuticals: Importance of Configurational Thermodynamic Quantities and Molecular Mobility

2002 ◽  
Vol 91 (8) ◽  
pp. 1863-1872 ◽  
Author(s):  
Deliang Zhou ◽  
Geoff G.Z. Zhang ◽  
Devalina Law ◽  
David J.W. Grant ◽  
Eric A. Schmitt
Keyword(s):  
Molecular Mobility ◽  
Physical Stability ◽  
Thermodynamic Quantities ◽  
Amorphous Pharmaceuticals

Physical Stability of the Amorphous Anticholesterol Agent (Ezetimibe): The Role of Molecular Mobility

2014 ◽  
Vol 11 (11) ◽  
pp. 4280-4290 ◽  
Author(s):  
J. Knapik ◽  
Z. Wojnarowska ◽  
K. Grzybowska ◽  
L. Hawelek ◽  
W. Sawicki ◽  
...  
Keyword(s):  
Molecular Mobility ◽  
Physical Stability

Role of free volume in molecular mobility and performance of glassy polymers for corrosion-protective coatings

2020 ◽  
Vol 55 (2) ◽  
pp. 145-158
Author(s):  
A. J. Hill ◽  
A. W. Thornton ◽  
R. H. J. Hannink ◽  
J. D. Moon ◽  
B. D. Freeman
Keyword(s):  
Free Volume ◽  
Molecular Mobility ◽  
Protective Coatings ◽  
Glassy Polymers ◽  
And Performance

Thermodynamic Principles for the Design of Polymers for Drug Formulations

2019 ◽  
Vol 10 (1) ◽  
pp. 311-335
Author(s):  
Michael Fischlschweiger ◽  
Sabine Enders
Keyword(s):  
Physical Stability ◽  
Ultrahigh Molecular Weight Polyethylene ◽  
Drug Formulation ◽  
Sufficient Time ◽  
Delivery Methods ◽  
Drug Solubilization ◽  
Drug Candidates ◽  
Ultrahigh Molecular Weight ◽  
Amorphous Dispersions

Polymers play an essential role in drug formulation and production of medical devices, implants, and diagnostics. Following drug discovery, an appropriate formulation is selected to enable drug delivery. This task can be exceedingly challenging owing to the large number of potential delivery methods and formulation and process variables that can interact in complex ways. This evolving solubility challenge has inspired an increasing emphasis on the developability of drug candidates in early discovery as well as various advanced drug solubilization strategies. Among the latter, formulation approaches that lead to prolonged drug supersaturation to maximize the driving force for sustained intestinal absorption of an oral product, or to allow sufficient time for injection after reconstitution of a parenteral lyophile formulation, have attracted increasing interest. Although several kinetic and thermodynamic components are involved in stabilizing amorphous dispersions, it is generally assumed that maximum physical stability, defined in terms of inhibition of drug crystallization, requires that the drug and excipient remain intimately mixed. Phase separation of the drug from its excipient may be the first step that ultimately leads to crystallization. We discuss the role of advanced thermodynamics using two examples: ASD and vitamin E–stabilized ultrahigh–molecular weight polyethylene implants.

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