Mechanism of Amorphous Itraconazole Stabilization in Polymer Solid Dispersions: Role of Molecular Mobility

2014 ◽  
Vol 11 (11) ◽  
pp. 4228-4237 ◽  
Author(s):  
Sunny P. Bhardwaj ◽  
Kapildev K. Arora ◽  
Elizabeth Kwong ◽  
Allen Templeton ◽  
Sophie-Dorothee Clas ◽  
...  
Keyword(s):  
Molecular Mobility ◽  
Solid Dispersions

Role of the Strength of Drug–Polymer Interactions on the Molecular Mobility and Crystallization Inhibition in Ketoconazole Solid Dispersions

2015 ◽  
Vol 12 (9) ◽  
pp. 3339-3350 ◽  
Author(s):  
Pinal Mistry ◽  
Sarat Mohapatra ◽  
Tata Gopinath ◽  
Frederick G. Vogt ◽  
Raj Suryanarayanan
Keyword(s):  
Molecular Mobility ◽  
Solid Dispersions ◽  
Crystallization Inhibition ◽  
Polymer Interactions

scholarly journals Insoluble Polymers in Solid Dispersions for Improving Bioavailability of Poorly Water-Soluble Drugs

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1679
Author(s):  
Thao T.D. Tran ◽  
Phuong H.L. Tran
Keyword(s):  
Solid Dispersion ◽  
Solid Dispersions ◽  
Water Soluble ◽  
Dissolution Enhancement ◽  
Formulation Development ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Insoluble Polymers

In recent decades, solid dispersions have been demonstrated as an effective approach for improving the bioavailability of poorly water-soluble drugs, as have solid dispersion techniques that include the application of nanotechnology. Many studies have reported on the ability to change drug crystallinity and molecular interactions to enhance the dissolution rate of solid dispersions using hydrophilic carriers. However, numerous studies have indicated that insoluble carriers are also promising excipients in solid dispersions. In this report, an overview of solid dispersion strategies involving insoluble carriers has been provided. In addition to the role of solubility and dissolution enhancement, the perspectives of the use of these polymers in controlled release solid dispersions have been classified and discussed. Moreover, the compatibility between methods and carriers and between drug and carrier is mentioned. In general, this report on solid dispersions using insoluble carriers could provide a specific approach and/or a selection of these polymers for further formulation development and clinical applications.

Role of free volume in molecular mobility and performance of glassy polymers for corrosion-protective coatings

2020 ◽  
Vol 55 (2) ◽  
pp. 145-158
Author(s):  
A. J. Hill ◽  
A. W. Thornton ◽  
R. H. J. Hannink ◽  
J. D. Moon ◽  
B. D. Freeman
Keyword(s):  
Free Volume ◽  
Molecular Mobility ◽  
Protective Coatings ◽  
Glassy Polymers ◽  
And Performance
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