Temperature-Sensitive Water-Soluble Polyelectrolyte/Surfactant Complexes Formed between Dodecyltrimethylammonium Bromide and a Comb-Type Copolymer Consisting of an Anionic Backbone and Poly(N-isopropylacrylamide) Side Chains

2006 ◽  
Vol 39 (1) ◽  
pp. 393-398 ◽  
Author(s):  
P. Tsolakis ◽  
G. Bokias
Keyword(s):  
Water Soluble ◽  
Temperature Sensitive ◽  
Side Chains ◽  
Dodecyltrimethylammonium Bromide

Selective Transport of Water-Soluble Proteins from Aqueous to Ionic Liquid Phase via a Temperature-Sensitive Phase Change of These Mixtures

2012 ◽  
Vol 65 (11) ◽  
pp. 1548 ◽  
Author(s):  
Yuki Kohno ◽  
Nobuhumi Nakamura ◽  
Hiroyuki Ohno
Keyword(s):  
Phase Change ◽  
Aqueous Phase ◽  
Selective Dissolution ◽  
Selective Extraction ◽  
Soluble Proteins ◽  
Water Soluble ◽  
Temperature Sensitive ◽  
Salting Out ◽  
Key Factor ◽  
The Difference

Mixtures of some ionic liquids (ILs) and water show reversible phase change between a homogeneous mixture and phase-separated state by a small change in temperature. Some water-soluble proteins have been migrated from the aqueous to the IL phase. When tetrabutylphosphonium 2,4,6-trimethylbenzenesulfonate was used as an IL, cytochrome c (Cyt.c) was found to be extracted from the water phase to the IL phase. Conversely, both horseradish peroxidase (HRP) and azurin remained in the aqueous phase. This selective extraction was comprehended to be due to the difference in solubility of these proteins in both phases. The separated aqueous phase contained a small amount of IL, which induced the salting-out of Cyt.c. On the other hand, condensed IL phase promoted the salting-in of Cyt.c. As a result, Cyt.c was preferably dissolved in the hydrated IL phase rather than aqueous phase. In the case of HRP, there was only a salting-out profile upon increasing the concentration of IL, which induced selective dissolution of HRP in the aqueous phase. These results clearly suggest that the profile of salting-out and salting-in for proteins is the key factor to facilitate the selective extraction of proteins from aqueous to the IL phase.

Water-soluble oligofluorenes bearing N1-alkylcytosine side chains as turn-on and turn-off materials in telomere DNA length sensing

2020 ◽  
Vol 56 (74) ◽  
pp. 10914-10917
Author(s):  
Isao Yamaguchi ◽  
Ryoga Ooe ◽  
Aohan Wang
Keyword(s):  
Soft Materials ◽  
Water Soluble ◽  
Side Chains ◽  
Turn On

Soft materials for telomere DNA length sensing were developed.

scholarly journals Synthesis of Highly Water-Soluble Adamantyl Phosphoinositide Derivatives

2015 ◽  
Vol 68 (4) ◽  
pp. 543 ◽  
Author(s):  
Mark Gregory ◽  
Meng-Xin Yin ◽  
Malcolm J. McConville ◽  
Eleanor Williams ◽  
Alex N. Bullock ◽  
...  
Keyword(s):  
Membrane Trafficking ◽  
Binding Proteins ◽  
Cell Signalling ◽  
Lipid Binding ◽  
Water Soluble ◽  
Side Chains ◽  
Phosphatidylinositol Phosphate ◽  
Phosphatidylinositol Phosphates ◽  
Lipid Binding Proteins ◽  
Natural Lipid

Phosphatidylinositol phosphates are key regulators of cell signalling pathways and membrane trafficking in eukaryotic cells, and there is a need for new chemical probes to further understand how they interact with lipid-binding proteins. Here, the synthesis of phosphatidylinositol phosphate analogues containing adamantyl carboxylic ester groups, in place of the natural lipid side chains, is described. These derivatives are considerably more soluble in water than analogues containing other lipid side chains and do not form large aggregates such as liposomes or micelles. These adamantyl analogues bind to known phosphoinositide-binding proteins with similar affinities to native ligands and will facilitate future studies on the substrate specificities of these proteins involving cocrystallisation studies with proteins.

Side chains contributions to characteristics of resistive memory based on water-soluble polyfluorenes: Effects of structure and length of side pendant group

2014 ◽  
Vol 15 (6) ◽  
pp. 1290-1298 ◽  
Author(s):  
Seung-Hoon Lee ◽  
Seung-Hwan Oh ◽  
Yongsung Ji ◽  
Juhwan Kim ◽  
Rira Kang ◽  
...  
Keyword(s):  
Water Soluble ◽  
Side Chains ◽  
Pendant Group ◽  
Resistive Memory

Thermo reversible hydrogel based delivery of mitomycin C for treatment of upper tract urothelial carcinoma (UTUC).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e16089-e16089 ◽  
Author(s):  
Jeffery Shyh-Jye Lin ◽  
Nir Kleinmann ◽  
Gregory J Wirth ◽  
Surena F. Matin ◽  
Gil Mayer ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Adverse Events ◽  
Mitomycin C ◽  
Unmet Need ◽  
Water Soluble ◽  
Phase Iii ◽  
Temperature Sensitive ◽  
Low Grade ◽  
Compassionate Use ◽  
Ureteral Catheter

e16089 Background: There is a large unmet need for novel drug delivery systems and effective therapy for UTUC, especially for patients with CKD and anatomic solitary kidneys. A temperature sensitive water-soluble gel formulation of Mitomycin C (MMC) demonstrated increased drug delivery time (4 to 6 hrs) and safety in the pelvicalyceal system of swine and human bladders. We report the efficacy and safety of gel+MMC as primary treatment (tx) of UTUC on a compassionate use basis. Methods: Compassionate use approval was obtained on an individual patient basis from the respective regulatory authorities and IRBs. 22 patients were approved for tx to date from 14 institutions in 4 countries. Tx included 6 weekly instillations instilled via ureteral catheter or percutaneous nephrostomy. Gel volume ranged from 5-20cc and MMC concentration was 2-6 mg/cc. Adverse events were recorded throughout treatment. Ureteroscopy was performed 2-6 weeks following tx completion for response determination. Results: Median age of the cohort was 75 yrs, with 15 males. 18 patients (pts) had low-grade (LG) tumor, 2 high-grade (HG), and 2 indeterminate grade. 16 (73%) completed treatment - 9 pts had a complete response, CR (41%; 59% of those who completed tx), 5 pts had a partial response, PR (23%; 31%), and 2 pts had no response, NR (9.1%, 12.5%). 4 patients could not complete tx due to adverse events (pyelonephritis, acute renal failure, pancytopenia, and unstable cardiac condition), 1 patient was diagnosed with a non-urothelial cancer during treatment, and 1 patient died prior to the third instillation due to suspected pulmonary embolus, determined to be unrelated to treatment with MitoGel. A total of 77 adverse events were recorded with 6 events related to MitoGel and serious (requiring intervention), and 21 events related to treatment and not serious. CR (9) and PR (5) were observed in 14 of 15 evaluable patients completing treatment for LG tumors. Conclusions: This compassionate use program of a thermosensitive gel+MMC for chemoablation of UTUC demonstrates proof of concept for treatment of low-grade tumors. A single arm Phase III multi-center registration trial to treat patients with low-grade renal pelvis tumors has been activated.

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