Self-Assembly of Squalene-Based Nucleolipids: Relating the Chemical Structure of the Bioconjugates to the Architecture of the Nanoparticles

Langmuir ◽  
2013 ◽  
Vol 29 (48) ◽  
pp. 14795-14803 ◽  
Author(s):  
Elise Lepeltier ◽  
Claudie Bourgaux ◽  
Véronique Rosilio ◽  
Jacques H. Poupaert ◽  
Florian Meneau ◽  
...  
Keyword(s):  
Self Assembly ◽  
Chemical Structure

STM investigation of the dependence of alkane and alkane (C18H38, C19H40) derivatives self-assembly on molecular chemical structure on HOPG surface

2008 ◽  
Vol 602 (6) ◽  
pp. 1256-1266 ◽  
Author(s):  
Qing Chen ◽  
Hui-Juan Yan ◽  
Cun-Ji Yan ◽  
Ge-Bo Pan ◽  
Li-Jun Wan ◽  
...  
Keyword(s):  
Self Assembly ◽  
Chemical Structure

scholarly journals Synthesis and Characterization of an Amphiphilic Linoleic Acid-g-Quaternary Chitosan with Low Toxicity

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Xiaobin Fang ◽  
Yingqi Xu ◽  
Jinming Zhang ◽  
Xianghong Lu ◽  
Yitao Wang ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
H Nmr ◽  
Low Toxicity ◽  
Low Cytotoxicity ◽  
Average Size ◽  
Novel Drug

A novel amphiphilic derivative of chitosan, namely, a linoleic acid-g-quaternary chitosan (LA-g-QC), was designed and synthesized as low toxic material for biomedical applications in this study. The chemical structure of LA-g-QC was characterized by Fourier transform infrared spectroscopy (FTIR),1H nuclear magnetic resonance (1H-NMR), and elemental analysis. LA-g-QC could form nanosized micelles with self-assembly, which was confirmed by the results of critical micelle concentration (CMC) via fluorescence spectroscopy. The average size of LA-g-QC was 140 nm and its zeta potential was approximately +35.50 mV. CMC value was 31.00 mg/mL. Furthermore, LA-g-QC micelles, at final concentrations between 0.94 μg/mL and 30 μg/mL, did not inhibit the proliferation of HepG2 or SMMC 7721 cell lines. Taken together, LA-g-QC has low cytotoxicity and high potential for the preparation of novel drug-delivery micelles.

scholarly journals The Importance of Reaction Conditions on the Chemical Structure of N,O-Acylated Chitosan Derivatives

Molecules ◽  
2019 ◽  
Vol 24 (17) ◽  
pp. 3047 ◽  
Author(s):  
Agnieszka Piegat ◽  
Agata Goszczyńska ◽  
Tomasz Idzik ◽  
Agata Niemczyk
Keyword(s):  
Self Assembly ◽  
Chemical Structure ◽  
Resonance Spectroscopy ◽  
Reaction Conditions ◽  
Chitosan Derivatives ◽  
Synthesis Conditions ◽  
Carbodiimide Hydrochloride ◽  
Selective Acylation ◽  
Reaction Media ◽  
Acylation Reactions

The structure of acylated chitosan derivatives strongly determines the properties of obtained products, influencing their hydrodynamic properties and thereby their solubility or self-assembly susceptibility. In the present work, the significance of slight changes in acylation conditions on the structure and properties of the products is discussed. A series of chitosan-acylated derivatives was synthesized by varying reaction conditions in a two-step process. As reaction media, two diluted acid solutions—i.e., acetic acid and hydrochloric acid)—and two coupling systems—i.e., 1-ethyl-3-(3-dimethyl-aminopropyl)-1-carbodiimide hydrochloride (EDC) and N–hydroxysulfosuccinimide (EDC/NHS)—were used. The chemical structure of the derivatives was studied in detail by means of two spectroscopic methods, namely infrared and nuclear magnetic resonance spectroscopy, in order to analyze the preference of the systems towards N- or O-acylation reactions, depending on the synthesis conditions used. The results obtained from advanced 1H-13C HMQC spectra emphasized the challenge of achieving a selective acylation reaction path. Additionally, the study of the molecular weight and solution behavior of the derivatives revealed that even slight changes in their chemical structure have an important influence on their final properties. Therefore, an exact knowledge of the obtained structure of derivatives is essential to achieve reaction reproducibility and to target the application.

Nature-likesynthetic alkyl branched-chain glycolipids: a review on chemical structure and self-assembly properties

2012 ◽  
Vol 39 (1) ◽  
pp. 1-17 ◽  
Author(s):  
Rauzah Hashim ◽  
Akihiko Sugimura ◽  
Hiroyuki Minamikawa ◽  
Thorsten Heidelberg
Keyword(s):  
Self Assembly ◽  
Chemical Structure ◽  
Branched Chain

Metal-Directed Self-Assembly of a Polyoxometalate-Based Molecular Triangle: Using Powerful Analytical Tools to Probe the Chemical Structure of Complex Supramolecular Assemblies

2015 ◽  
Vol 21 (52) ◽  
pp. 19010-19015 ◽  
Author(s):  
Guillaume Izzet ◽  
Andrew Macdonell ◽  
Corentin Rinfray ◽  
Madeleine Piot ◽  
Séverine Renaudineau ◽  
...  
Keyword(s):  
Self Assembly ◽  
Chemical Structure ◽  
Supramolecular Assemblies ◽  
Analytical Tools

ChemInform Abstract: Nature-Like Synthetic Alkyl Branched Chain Glycolipids: Chemical Structure and Self-Assembly Properties

ChemInform ◽  
2012 ◽  
Vol 43 (15) ◽  
pp. no-no
Author(s):  
Rauzah Hashim ◽  
Akihiko Sugimura ◽  
Hiroyuki Minamikawa ◽  
Thorsten Heidelberg
Keyword(s):  
Self Assembly ◽  
Chemical Structure ◽  
Branched Chain
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