scholarly journals Synthesis and Characterization of an Amphiphilic Linoleic Acid-g-Quaternary Chitosan with Low Toxicity

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Xiaobin Fang ◽  
Yingqi Xu ◽  
Jinming Zhang ◽  
Xianghong Lu ◽  
Yitao Wang ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
H Nmr ◽  
Low Toxicity ◽  
Low Cytotoxicity ◽  
Average Size ◽  
Novel Drug

A novel amphiphilic derivative of chitosan, namely, a linoleic acid-g-quaternary chitosan (LA-g-QC), was designed and synthesized as low toxic material for biomedical applications in this study. The chemical structure of LA-g-QC was characterized by Fourier transform infrared spectroscopy (FTIR),1H nuclear magnetic resonance (1H-NMR), and elemental analysis. LA-g-QC could form nanosized micelles with self-assembly, which was confirmed by the results of critical micelle concentration (CMC) via fluorescence spectroscopy. The average size of LA-g-QC was 140 nm and its zeta potential was approximately +35.50 mV. CMC value was 31.00 mg/mL. Furthermore, LA-g-QC micelles, at final concentrations between 0.94 μg/mL and 30 μg/mL, did not inhibit the proliferation of HepG2 or SMMC 7721 cell lines. Taken together, LA-g-QC has low cytotoxicity and high potential for the preparation of novel drug-delivery micelles.

scholarly journals A New Hope: Self-Assembling Peptides with Antimicrobial Activity

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 166 ◽  
Author(s):  
Lucia Lombardi ◽  
Annarita Falanga ◽  
Valentina Del Genio ◽  
Stefania Galdiero
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
High Specificity ◽  
Antibacterial Activities ◽  
Mechanisms Of Action ◽  
Great Promise ◽  
Functional Nanomaterials ◽  
Self Assembling ◽  
Low Toxicity ◽  
Bio Compatibility

Peptide drugs hold great promise for the treatment of infectious diseases thanks to their novel mechanisms of action, low toxicity, high specificity, and ease of synthesis and modification. Naturally developing self-assembly in nature has inspired remarkable interest in self-assembly of peptides to functional nanomaterials. As a matter of fact, their structural, mechanical, and functional advantages, plus their high bio-compatibility and bio-degradability make them excellent candidates for facilitating biomedical applications. This review focuses on the self-assembly of peptides for the fabrication of antibacterial nanomaterials holding great interest for substituting antibiotics, with emphasis on strategies to achieve nano-architectures of self-assembly. The antibacterial activities achieved by these nanomaterials are also described.

Synthesis of biomass based plasticizer from linoleic acid and cardanol for preparing durable PVC material

2021 ◽  
Author(s):  
Hongying Chu ◽  
Huabei Li ◽  
Xiaoyan Sun ◽  
Yaowang Zhang
Keyword(s):  
Thermal Stability ◽  
Linoleic Acid ◽  
Chemical Structure ◽  
Dioctyl Phthalate ◽  
H Nmr ◽  
Plasticized Pvc ◽  
Migration Resistance ◽  
Ft Ir ◽  
And Migration ◽  
Thermal Stability Of

Abstract In this paper, we synthesized a kind of bio-based plasticizer epoxidized linoleic acid cardanol ester(ELCE) from cardanol and linoleic acid. Its chemical structure was characterized with FT-IR and 1H NMR. Polyvinyl chloride(PVC) blends plasticized with ELCE were prepared via thermoplastic blending with torque rheometer. The performance including torque, mechanical property, thermal stability, plasticizing property and migration resistance of plasticized PVC blends were investigated and compared with plasticized PVC blends with commercial plasticizer dioctyl phthalate(DOP). The results showed that ELCE improved thermal stability of PVC blends. ELCE played more excellent plasticizing effect on PVC blends than DOP. The better solvent extraction resistance and volatile resistance of ELCE make it impossible to completely replace DOP in PVC products.

Synthesis and Characterization of an Alendronate-Chitosan Conjugate

2011 ◽  
Vol 140 ◽  
pp. 53-57 ◽  
Author(s):  
Xiao Hong Shao ◽  
Ji Qing Xu ◽  
Yan Peng Jiao ◽  
Chang Ren Zhou
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Synthesis And Characterization ◽  
Hydroxyl Groups ◽  
Amino Groups ◽  
H Nmr ◽  
Ft Ir ◽  
Novel Drug Delivery System ◽  
Novel Drug

The biomineral-binding alendronate-chitosan conjugate (Scheme 1) was developed as a novel drug delivery system. Alendronate was conjugated to the hydroxyl groups of chitosan, thereby maintaining the amino groups of chitosan intact. By means of FT-IR and 1H NMR, the characterization was conducted to confirm the successful synthesis of alendronate-chitosan conjugate.

Molecular weight and contraction factors of hyperbranched poly(urea-urethane)s

e-Polymers ◽  
2006 ◽  
Vol 6 (1) ◽  
Author(s):  
Albena Lederer ◽  
Mona Abd Elrehim ◽  
Falko Schallausky ◽  
Dieter Voigt ◽  
Brigitte Voit
Keyword(s):  
Chemical Structure ◽  
Molar Mass ◽  
Molecular Shape ◽  
Branched Polymers ◽  
Compact Structure ◽  
H Nmr ◽  
Hyperbranched Poly ◽  
End Groups ◽  
Solution Behaviour

AbstractElution fractionations of broadly molar mass-distributed, hyperbranched poly(urea-urethane)s with OH- and Ph- end groups were carried out to obtain a number of macromolecular samples possessing different molar masses at the same chemical structure. The characterization of the polymers was performed by SEC, MALLS, 1H-NMR, MALDI-TOF-MS and viscosity measurements. Modifications of the OH-end groups of the polymers were carried out. We observed a strong influence of the end groups on the solution behaviour of the hyperbranched samples. The molecular shape of the hyperbranched polymers in solution was compared to their linear analogue using the Kuhn-Mark-Houwink- Sakurada relationship. The calculated contraction factors between 0,15 and 0,7 depending on the molar masses correspond to a very compact structure of the modified branched polymers at high molar masses.

Characterization of Poly(Diethylene Glycol Adipate -co- Neopentylglycol Adipate) as a New Plasticizer for Poly(Lactic Acid)

2013 ◽  
Vol 706-708 ◽  
pp. 28-31
Author(s):  
Tong Wan ◽  
Si Zhang ◽  
Tao Du
Keyword(s):  
Lactic Acid ◽  
Shear Rate ◽  
Diethylene Glycol ◽  
Parallel Plate ◽  
Chemical Structure ◽  
Poly Lactic Acid ◽  
Glycol Adipate ◽  
H Nmr ◽  
Biodegradable Blends

A new poly (diethylene glycol adipate -co- neopentylglycol adipate) (PDNA) was synthesized from diethylene glycol adipate (DEAP) with neopentylglycol adipate (NPAP). The chemical structure of PDNA was characterized by 1H-NMR. PLA was plasticized by various amount of PDNA to obtain biodegradable blends. The effects of both temperature and shear rate on the rheologies of PLA/PDNA blends were evaluated by a parallel plate rheometer.

Self-assembly of trinitrofluorenone derivatives with tetrasubstituted zinc phthalocyanines

2009 ◽  
Vol 13 (02) ◽  
pp. 266-274 ◽  
Author(s):  
Francisco J. Céspedes-Guirao ◽  
Luis Martín-Gomis ◽  
Fernando Fernández-Lázaro ◽  
Ángela Sastre-Santos
Keyword(s):  
Column Chromatography ◽  
Self Assembly ◽  
Synthesis And Characterization ◽  
H Nmr ◽  
First Case ◽  
Zinc Phthalocyanines ◽  
System 2 ◽  
System 1 ◽  
Supramolecular Complexation

The synthesis and characterization of two novel tetrasubstituted zinc phthalocyanines bearing bulky alkylaryloxy substituents in the so-called peripheral (1) and non-peripheral (2) positions is reported. Due to the presence of these bulky substituents, the non-peripheral substituted ZnPc 2 can be isolated as a pure regioisomer just by column chromatography. This is the first case where an α,α,α,α-tetrasubstituted regioisomer is isolated by column chromatography. Moreover, we describe the supramolecular complexation of both Pcs with the new pyridine-substituted trinitrofluorenone derivative TNFPy (3), whose synthesis and characterization is also commented. 1 H NMR titration experiments show that the system 2/3 presents a binding constant 35 times higher than system 1/3, which suggests a better accessibility to the metallic center.

Reduction-Degradable Shell Cross-Linked Micelle with pH-Responsive Cores Prepared via Click Chemistry

2016 ◽  
Vol 848 ◽  
pp. 527-531
Author(s):  
Lu Bin Lin ◽  
Qing Yun Yu ◽  
Zhuo Qun Gu ◽  
Xiao Ze Jiang ◽  
Mei Fang Zhu
Keyword(s):  
Click Chemistry ◽  
Self Assembly ◽  
Gel Permeation Chromatography ◽  
Proton Nuclear Magnetic Resonance ◽  
Poly Ethylene Glycol ◽  
H Nmr ◽  
Transmission Electron ◽  
Assembly Behavior ◽  
Poly Ethylene ◽  
Novel Drug

A well-defined poly [(ethylene glycol)-block-2-(dimethylamino) ethyl methacrylate-block-2-(diethylamino) methacrylate] (PEG-b-DMA-b-DEA) triblock copolymer was synthesized via atom transfer radical polymerization (ATRP) by successively polymerization of DMA and DEA monomers using a PEG-based macroinitiator, and obtained copolymer was then converted to be PEG-b-P(DMA-co-QDMA)-b-PDEA copolymer with “clickable” moieties in the middle block by the quaternization with propargyl bromide. Those copolymers prepared were characterized by proton Nuclear Magnetic Resonance (1H NMR) and Gel Permeation Chromatography (GPC), and its self-assembly behavior and subsequently fixation with bis-(azidoethyl) disulfide via click chemistry resulting reduction-sensitive shell-cross-linked (SCL) micelle in purely aqueous solution were investigated by Transmission Electron Microscopy (TEM) and Dynamic Light Scattering (DLS). The results show the micellar structure could be effectively cross-linked via click chemistry and also be dissociated at reduction condition, which may realize it's potential application as novel drug delivery carriers.

Coordination arrays — Synthesis and characterization of tetranuclear complexes of grid-type

2004 ◽  
Vol 82 (10) ◽  
pp. 1428-1434 ◽  
Author(s):  
Garry S Hanan ◽  
Dirk Volkmer ◽  
Jean-Marie Lehn
Keyword(s):  
Metal Ions ◽  
Self Assembly ◽  
Metal Ion ◽  
Transition Metal Ions ◽  
Tridentate Ligands ◽  
H Nmr ◽  
Nitrogen Ligands ◽  
Metal Metal ◽  
Tetranuclear Complexes

A series of tetranuclear metal complexes of grid-type consisting of four bis-tridentate ligands and four divalent transition metal ions were synthesized and characterized. The 1H NMR spectra of diamagnetic complexes containing Zn(II), Cd(II), Fe(II), and Ru(II) was correlated to the radius of the metal ion. The UV–vis and electrochemical results indicated that the bridging ligand π* orbital and the dπ metal orbital are stabilized by complexation of more than one metal ion. Furthermore, the Co(II) and Fe(II) grids exhibit metal–metal interaction mediated by the bis-tridentate ligands as indicated by electrochemical and spectroscopic methods. These results provide guidelines for the design of larger grids bearing several metal centres in a square arrangement, which also represent potential components of molecular electronic devices.Key words: complexes with nitrogen ligands, octahedral metal ions, self-assembly, supramolecular chemistry.

scholarly journals Synthesis and characterization of innovative poly(lactide-co-glycolide)-(poly-l-ornithine/fucoidan) core–shell nanocarriers by layer-by-layer self-assembly

RSC Advances ◽  
2017 ◽  
Vol 7 (52) ◽  
pp. 32786-32794 ◽  
Author(s):  
Jingqian Fan ◽  
Yuangang Liu ◽  
Shibin Wang ◽  
Yulu Liu ◽  
Siming Li ◽  
...  
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Synthesis And Characterization ◽  
Core Shell ◽  
Layer By Layer

Layer-by-Layer (LbL) self-assembly of nanocarriers has garnered the interest of researchers for a wide variety of biomedical applications.

scholarly journals Low-toxicity metallosomes for biomedical applications by self-assembly of organometallic metallosurfactants and phospholipids

2017 ◽  
Vol 53 (60) ◽  
pp. 8455-8458 ◽  
Author(s):  
M. Marín-García ◽  
N. Benseny-Cases ◽  
M. Camacho ◽  
J. Suades ◽  
R. Barnadas-Rodríguez
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Cell Toxicity ◽  
Straightforward Method ◽  
Low Toxicity

New photo-CORM metallosomes prepared by a straightforward method from organometallic metallosurfactants and phospholipids show a drastic diminution of cell toxicity.

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