Enhanced Protein Adsorption Due to Charge Regulation

Langmuir ◽  
2005 ◽  
Vol 21 (18) ◽  
pp. 8385-8388 ◽  
Author(s):  
Mikael Lund ◽  
Torbjörn Åkesson ◽  
Bo Jönsson
Keyword(s):  
Protein Adsorption ◽  
Charge Regulation

Protein Adsorption at Charged Surfaces: The Role of Electrostatic Interactions and Interfacial Charge Regulation

Langmuir ◽  
2011 ◽  
Vol 27 (6) ◽  
pp. 2634-2643 ◽  
Author(s):  
Rune A. Hartvig ◽  
Marco van de Weert ◽  
Jesper Østergaard ◽  
Lene Jorgensen ◽  
Henrik Jensen
Keyword(s):  
Protein Adsorption ◽  
Electrostatic Interactions ◽  
Charge Regulation ◽  
Charged Surfaces ◽  
Interfacial Charge

Formation of Dielectric Layers and Charge Regulation in Protein Adsorption at Biomimetic Interfaces

Langmuir ◽  
2012 ◽  
Vol 28 (3) ◽  
pp. 1804-1815 ◽  
Author(s):  
Rune A. Hartvig ◽  
Marco van de Weert ◽  
Jesper Østergaard ◽  
Lene Jorgensen ◽  
Henrik Jensen
Keyword(s):  
Protein Adsorption ◽  
Charge Regulation ◽  
Dielectric Layers ◽  
Biomimetic Interfaces

scholarly journals Electrostatically Driven Protein Adsorption: Charge Patches versus Charge Regulation

Langmuir ◽  
2018 ◽  
Vol 34 (51) ◽  
pp. 15727-15738 ◽  
Author(s):  
F. M. Boubeta ◽  
G. J. A. A. Soler-Illia ◽  
M. Tagliazucchi
Keyword(s):  
Protein Adsorption ◽  
Charge Regulation

Effect of Sintering Processes on Surface Properties and Protein Adsorption of Hydroxyapatite Ceramic Particles

2010 ◽  
Vol 25 (7) ◽  
pp. 770-774 ◽  
Author(s):  
Hui-Jie ZHANG ◽  
Xiang-Dong ZHU ◽  
Xin-Long WANG ◽  
Hong-Song FAN ◽  
Xing-Dong ZHANG
Keyword(s):  
Protein Adsorption ◽  
Surface Properties ◽  
Hydroxyapatite Ceramic ◽  
Ceramic Particles ◽  
Sintering Processes

Controlled radical polymerization of hydrophilic and zwitterionic brush-like polymers from silk fibroin surfaces

2020 ◽  
Vol 8 (45) ◽  
pp. 10392-10406
Author(s):  
Danielle L. Heichel ◽  
Ngoc Chau H. Vy ◽  
Shawn P. Ward ◽  
Douglas H. Adamson ◽  
Kelly A. Burke
Keyword(s):  
Protein Adsorption ◽  
Radical Polymerization ◽  
Silk Fibroin ◽  
Cell Attachment ◽  
Controlled Radical Polymerization

Silk fibroin films were modified with zwitterionic and hydrophilic brush-like polymers via surface-initiated ATRP, resulting in surfaces that reduced protein adsorption and cell attachment.

scholarly journals Charge Regulation at a Nanoporous Two-Dimensional Interface

ACS Omega ◽  
2021 ◽  
Vol 6 (4) ◽  
pp. 2487-2493
Author(s):  
Mandakranta Ghosh ◽  
Moritz A. Junker ◽  
Robert T. M. van Lent ◽  
Lukas Madauß ◽  
Marika Schleberger ◽  
...  
Keyword(s):  
Two Dimensional ◽  
Charge Regulation

scholarly journals Influence of calcium ion-modified implant surfaces in protein adsorption and implant integration

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Eduardo Anitua ◽  
Andreia Cerqueira ◽  
Francisco Romero-Gavilán ◽  
Iñaki García-Arnáez ◽  
Cristina Martinez-Ramos ◽  
...  
Keyword(s):  
Protein Adsorption ◽  
Titanium Implant ◽  
Volume Density ◽  
Bone Implant ◽  
The Mean ◽  
Intervention Costs ◽  
Medial Section ◽  
Post Implantation

Abstract Background Calcium (Ca) is a well-known element in bone metabolism and blood coagulation. Here, we investigate the link between the protein adsorption pattern and the in vivo responses of surfaces modified with calcium ions (Ca-ion) as compared to standard titanium implant surfaces (control). We used LC–MS/MS to identify the proteins adhered to the surfaces after incubation with human serum and performed bilateral surgeries in the medial section of the femoral condyles of 18 New Zealand white rabbits to test osseointegration at 2 and 8 weeks post-implantation (n=9). Results Ca-ion surfaces adsorbed 181.42 times more FA10 and 3.85 times less FA12 (p<0.001), which are factors of the common and the intrinsic coagulation pathways respectively. We also detected differences in A1AT, PLMN, FA12, KNG1, HEP2, LYSC, PIP, SAMP, VTNC, SAA4, and CFAH (p<0.01). At 2 and 8 weeks post-implantation, the mean bone implant contact (BIC) with Ca-ion surfaces was respectively 1.52 and 1.25 times higher, and the mean bone volume density (BVD) was respectively 1.35 and 1.13 times higher. Differences were statistically significant for BIC at 2 and 8 weeks and for BVD at 2 weeks (p<0.05). Conclusions The strong thrombogenic protein adsorption pattern at Ca-ion surfaces correlated with significantly higher levels of implant osseointegration. More effective implant surfaces combined with smaller implants enable less invasive surgeries, shorter healing times, and overall lower intervention costs, especially in cases of low quantity or quality of bone.

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