Formation of Rigid Organic Nanotubes with Controlled Internal Cavity Based on Frustrated Aggregate Internal Rearrangement Mechanism

2013 ◽  
Vol 117 (25) ◽  
pp. 7763-7770 ◽  
Author(s):  
Minwoo Han ◽  
Jungin Hyun ◽  
Eunji Sim
Keyword(s):  
Internal Cavity ◽  
Rearrangement Mechanism ◽  
Organic Nanotubes ◽  
Internal Rearrangement

Internal cavity characteristics of northern long-eared bat (Myotis septentrionalis) maternity day-roosts

2015 ◽  
Author(s):  
Alexander Silvis ◽  
R. Edward Thomas ◽  
W. Mark Ford ◽  
Eric R. Britzke ◽  
Meryl J. Friedrich
Keyword(s):  
Internal Cavity ◽  
Myotis Septentrionalis ◽  
Cavity Characteristics

scholarly journals Fusion genes in gynecologic tumors: the occurrence, molecular mechanism and prospect for therapy

2021 ◽  
Vol 12 (8) ◽  
Author(s):  
Bingfeng Lu ◽  
Ruqi Jiang ◽  
Bumin Xie ◽  
Wu Wu ◽  
Yang Zhao
Keyword(s):  
Tumor Progression ◽  
Massively Parallel Sequencing ◽  
Gynecologic Cancer ◽  
Endometrial Stromal Sarcoma ◽  
Driver Mutations ◽  
Fusion Genes ◽  
Stromal Sarcoma ◽  
Uterine Tumors ◽  
Rearrangement Mechanism ◽  
Gynecologic Tumors

AbstractGene fusions are thought to be driver mutations in multiple cancers and are an important factor for poor patient prognosis. Most of them appear in specific cancers, thus satisfactory strategies can be developed for the precise treatment of these types of cancer. Currently, there are few targeted drugs to treat gynecologic tumors, and patients with gynecologic cancer often have a poor prognosis because of tumor progression or recurrence. With the application of massively parallel sequencing, a large number of fusion genes have been discovered in gynecologic tumors, and some fusions have been confirmed to be involved in the biological process of tumor progression. To this end, the present article reviews the current research status of all confirmed fusion genes in gynecologic tumors, including their rearrangement mechanism and frequency in ovarian cancer, endometrial cancer, endometrial stromal sarcoma, and other types of uterine tumors. We also describe the mechanisms by which fusion genes are generated and their oncogenic mechanism. Finally, we discuss the prospect of fusion genes as therapeutic targets in gynecologic tumors.

scholarly journals Cyclodextrins, Natural Compounds, and Plant Bioactives—A Nutritional Perspective

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 401
Author(s):  
Svenja Wüpper ◽  
Kai Lüersen ◽  
Gerald Rimbach
Keyword(s):  
Intestinal Flora ◽  
Aqueous Solubility ◽  
Outer Wall ◽  
Natural Compounds ◽  
Model Organisms ◽  
Laboratory Model ◽  
Internal Cavity ◽  
Pentacyclic Triterpenoids ◽  
Starch Derivatives ◽  
Improved Stability

Cyclodextrins (CDs) are a group of cyclic oligosaccharides produced from starch or starch derivatives. They contain six (αCD), seven (βCD), eight (γCD), or more glucopyranose monomers linked via α-1,4-glycosidic bonds. CDs have a truncated cone shape with a hydrophilic outer wall and a less hydrophilic inner wall, the latter forming a more apolar internal cavity. Because of this special architecture, CDs are soluble in water and can simultaneously host lipophilic guest molecules. The major advantage of inclusion into CDs is increased aqueous solubility of such lipophilic substances. Accordingly, we present studies where the complexation of natural compounds such as propolis and dietary plant bioactives (e.g., tocotrienol, pentacyclic triterpenoids, curcumin) with γCD resulted in improved stability, bioavailability, and bioactivity in various laboratory model organisms and in humans. We also address safety aspects that may arise from increased bioavailability of plant extracts or natural compounds owing to CD complexation. When orally administered, α- and βCD—which are inert to intestinal digestion—are fermented by the human intestinal flora, while γCD is almost completely degraded to glucose units by α-amylase. Hence, recent reports indicate that empty γCD supplementation exhibits metabolic activity on its own, which may provide opportunities for new applications.

A Surprisingly Gentle Approach to Cavity Containing Spherocylindrical Microparticles from Ordinary Polymer Dispersions in Flow

2021 ◽  
Author(s):  
Amit K. Tripathi ◽  
John G. Tsavalas
Keyword(s):  
Internal Cavity ◽  
Polymeric Microparticles ◽  
Polymer Dispersions

Herein, we demonstrate a facile approach to fully transform spherical polymeric microparticles to elongated spherocylinders containing an internal cavity under ambient and mild stirring conditions. Critical to the process is...

scholarly journals Microfluidics for the rapid and controlled preparation of organic nanotubes of bent-core based dendrimers

2021 ◽  
Author(s):  
M. Blanca Ros ◽  
Martín Castillo-Vallés ◽  
Pilar Romero ◽  
Victor Sebastian
Keyword(s):  
Building Blocks ◽  
Microfluidic System ◽  
Promising Tool ◽  
Organic Nanotubes ◽  
Controlled Preparation

Recently, bent-core molecules have arised as excellent building blocks for the obtaining of nanostructures in solvents. Herein, we report the use of a coaxial microfluidic system as a promising tool...

The quest for hydrogen bond-based metal organic nanotubes (MONT)

2014 ◽  
Vol 67 (23-24) ◽  
pp. 3863-3872 ◽  
Author(s):  
Andrea Ienco ◽  
Maria Caporali ◽  
Ferdinando Costantino ◽  
Annalisa Guerri ◽  
Gabriele Manca ◽  
...  
Keyword(s):  
Hydrogen Bond ◽  
Metal Organic ◽  
Organic Nanotubes

scholarly journals Diversity in the structures and ligand-binding sites of nematode fatty acid and retinol-binding proteins revealed by Na-FAR-1 from Necator americanus

2015 ◽  
Vol 471 (3) ◽  
pp. 403-414 ◽  
Author(s):  
M. Florencia Rey-Burusco ◽  
Marina Ibáñez-Shimabukuro ◽  
Mads Gabrielsen ◽  
Gisela R. Franchini ◽  
Andrew J. Roe ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Ligand Binding ◽  
Tissue Distribution ◽  
Binding Sites ◽  
Binding Proteins ◽  
Retinol Binding Protein ◽  
Internal Cavity ◽  
Binding Characteristics ◽  
Necator Americanus ◽  
Ligand Binding Sites

Necator americanus fatty acid and retinol-binding protein-1 (Na-FAR-1) is an abundantly expressed FAR from a parasitic hookworm. The present work describes its tissue distribution, structure and ligand-binding characteristics and shows that Na-FAR-1 expands to transport multiple FA molecules in its internal cavity.

Folate-targeted single-wall metal-organic nanotubes used as multifunctional drug carriers

2017 ◽  
Vol 392 ◽  
pp. 189-195 ◽  
Author(s):  
Linyan Yang ◽  
Min Liu ◽  
Kebin Huang ◽  
Xia Ai ◽  
Cun Li ◽  
...  
Keyword(s):  
Drug Carriers ◽  
Metal Organic ◽  
Organic Nanotubes
Sign in / Sign up

Export Citation Format

Share Document