scholarly journals Microfluidics for the rapid and controlled preparation of organic nanotubes of bent-core based dendrimers

2021 ◽  
Author(s):  
M. Blanca Ros ◽  
Martín Castillo-Vallés ◽  
Pilar Romero ◽  
Victor Sebastian
Keyword(s):  
Building Blocks ◽  
Microfluidic System ◽  
Promising Tool ◽  
Organic Nanotubes ◽  
Controlled Preparation

Recently, bent-core molecules have arised as excellent building blocks for the obtaining of nanostructures in solvents. Herein, we report the use of a coaxial microfluidic system as a promising tool...

Helical Organic Nanotubes from Simple Chiral Building Blocks

2013 ◽  
Vol 13 (10) ◽  
pp. 6961-6966
Author(s):  
Wei Wei ◽  
Kun Huang ◽  
Chih-Ning Pao ◽  
Zuming Hu ◽  
Yunfeng Lu
Keyword(s):  
Building Blocks ◽  
Organic Nanotubes

scholarly journals Modular operation of microfluidic chips for highly parallelized cell culture and liquid dosing via a fluidic circuit board

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
A. R. Vollertsen ◽  
D. de Boer ◽  
S. Dekker ◽  
B. A. M. Wesselink ◽  
R. Haverkate ◽  
...  
Keyword(s):  
Cell Culture ◽  
Large Scale ◽  
Dynamic Range ◽  
Umbilical Vein ◽  
Building Blocks ◽  
High Dynamic Range ◽  
Microfluidic System ◽  
Circuit Board ◽  
Microfluidic Chips ◽  
Umbilical Vein Endothelial Cells

AbstractMicrofluidic systems enable automated and highly parallelized cell culture with low volumes and defined liquid dosing. To achieve this, systems typically integrate all functions into a single, monolithic device as a “one size fits all” solution. However, this approach limits the end users’ (re)design flexibility and complicates the addition of new functions to the system. To address this challenge, we propose and demonstrate a modular and standardized plug-and-play fluidic circuit board (FCB) for operating microfluidic building blocks (MFBBs), whereby both the FCB and the MFBBs contain integrated valves. A single FCB can parallelize up to three MFBBs of the same design or operate MFBBs with entirely different architectures. The operation of the MFBBs through the FCB is fully automated and does not incur the cost of an extra external footprint. We use this modular platform to control three microfluidic large-scale integration (mLSI) MFBBs, each of which features 64 microchambers suitable for cell culturing with high spatiotemporal control. We show as a proof of principle that we can culture human umbilical vein endothelial cells (HUVECs) for multiple days in the chambers of this MFBB. Moreover, we also use the same FCB to control an MFBB for liquid dosing with a high dynamic range. Our results demonstrate that MFBBs with different designs can be controlled and combined on a single FCB. Our novel modular approach to operating an automated microfluidic system for parallelized cell culture will enable greater experimental flexibility and facilitate the cooperation of different chips from different labs.

scholarly journals Ultrafast laser manufacturing of nanofluidic systems

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Felix Sima ◽  
Koji Sugioka
Keyword(s):  
Fluid Dynamics ◽  
Three Dimensional ◽  
Microfluidic System ◽  
Ultrafast Laser ◽  
Cancer Cell Migration ◽  
Extracellular Milieu ◽  
Promising Tool ◽  
Molecular Events ◽  
Laser Manufacturing ◽  
Chemical Fields

Abstract In the last decades, research and development of microfluidics have made extraordinary progress, since they have revolutionized the biological and chemical fields as a backbone of lab-on-a-chip systems. Further advancement pushes to miniaturize the architectures to nanoscale in terms of both the sizes and the fluid dynamics for some specific applications including investigation of biological sub-cellular aspects and chemical analysis with much improved detection limits. In particular, nano-scale channels offer new opportunities for tests at single cell or even molecular levels. Thus, nanofluidics, which is a microfluidic system involving channels with nanometer dimensions typically smaller than several hundred nm, has been proposed as an ideal platform for investigating fundamental molecular events at the cell-extracellular milieu interface, biological sensing, and more recently for studying cancer cell migration in a space much narrower than the cell size. In addition, nanofluidics can be used for sample manipulation in analytical chemistry, such as sample injections, separation, purifications or for quantitative and qualitative determinations. Among the nanofabrication technologies, ultrafast laser manufacturing is a promising tool for fabrication of nanofluidics due to its flexibility, versatility, high fabrication resolution and three dimensional (3D) fabrication capability. In this paper, we review the technological advancements of nanofluidic systems, with emphasis on fabrication methods, in particular ultrafast laser manufacturing. We present the challenges for issues concerning channel sizes and fluid dynamics, and introduce the applications in physics, biology, chemistry and engineering with future prospects.

Fluidic and Electronic Transport in Silicon Nanotube Biosensors

MRS Advances ◽  
2016 ◽  
Vol 1 (56) ◽  
pp. 3761-3766 ◽  
Author(s):  
Nicolas Hibst ◽  
Annina M. Steinbach ◽  
Steffen Strehle
Keyword(s):  
Electronic Transport ◽  
Field Effect Transistors ◽  
Building Blocks ◽  
Microfluidic System ◽  
Label Free ◽  
Ion Diffusion ◽  
Charge Sensing ◽  
Silicon Nanotubes ◽  
Order Of Magnitude ◽  
Electronic Sensing

ABSTRACTSilicon nanotubes (SiNTs) represent unique building blocks for future nanoscale biosensor devices merging electronic sensing and nanofluidics. Configured as ion-sensitive field effect transistors (ISFETs), SiNTs have great potential for charge sensing or label-free chemical detection in minute sample volumes flowing through their inner cavity. In the present study, doped SiNTs were synthesized from the gas phase in a bottom-up approach. To study their nanofluidic and electronic transport properties, single SiNTs were functionally integrated as ISFETs and coupled to a microfluidic system. The experimental results for ion diffusion through a SiNT are in full agreement with numerical calculations based on Fick's second law if a diffusion coefficient is assumed approximately one order of magnitude smaller than the bulk value.

ATOMISTIC MODELING AND MECHANICS OF SELF-ASSEMBLED ORGANIC NANOTUBES

2011 ◽  
Vol 03 (04) ◽  
pp. 667-684 ◽  
Author(s):  
LUIS RUIZ ◽  
SINAN KETEN
Keyword(s):  
Hydrogen Bonds ◽  
Large Scale ◽  
Shear Failure ◽  
Cyclic Peptide ◽  
Building Blocks ◽  
Great Promise ◽  
Deformation And Failure ◽  
Self Assembling ◽  
Self Assembled ◽  
Organic Nanotubes

Organic building blocks inspired by biological systems are promising for fabricating nanostructured materials for a broad range of applications such as antimicrobials, biosensors, electronics, and biomaterials. Self-assembling cyclic peptide organic nanotubes have shown great promise for these applications due to their precise structural features, diverse chemical functionalization capabilities and exceptional stability arising from arrangement of hydrogen bonds into cooperative clusters. Mechanical behavior of organic nanotubes is important for various possible applications ranging from subnanoporous selective membranes to molecular templates for electronics. However, large-scale deformation mechanisms of organic nanotubes have not been studied thus far. Here we investigate the mechanisms involved in the large deformation and failure of self-assembled organic nanotubes, focusing on geometry effects characteristic of protein nanostructures. We carry out molecular dynamics simulations to assess the role of hydrogen bonds as weak interactions in the context of deformation and failure processes involving bending and shear loads. Mechanisms of failure are found to depend on the cross-sectional geometry and the deformation rate, where a transition to localized shear failure is observed at high-strain rates. Our results provide important physical insight into the mechanics of organic nanotubes central to emerging applications of self-assembling peptides in biomedicine and biotechnology.

A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex

2014 ◽  
Vol 70 (2) ◽  
pp. 362-370 ◽  
Author(s):  
Irene Russo Krauss ◽  
Gary Nigel Parkinson ◽  
Antonello Merlino ◽  
Carlo Andrea Mattia ◽  
Antonio Randazzo ◽  
...  
Keyword(s):  
Self Assembly ◽  
Supramolecular Assembly ◽  
Building Blocks ◽  
Crystallographic Analysis ◽  
Order Structure ◽  
Promising Tool ◽  
G Quadruplex ◽  
Nuclease Resistance ◽  
Diagnostic Applications ◽  
Structural Descriptions

Locked nucleic acids (LNAs) are formed by bicyclic ribonucleotides where the O2′ and C4′ atoms are linked through a methylene bridge and the sugar is blocked in a 3′-endoconformation. They represent a promising tool for therapeutic and diagnostic applications and are characterized by higher thermal stability and nuclease resistance with respect to their natural counterparts. However, structural descriptions of LNA-containing quadruplexes are rather limited, since few NMR models have been reported in the literature. Here, the first crystallographically derived model of an all-LNA-substituted quadruplex-forming sequence 5′-TGGGT-3′ is presented refined at 1.7 Å resolution. This high-resolution crystallographic analysis reveals a regular parallel G-quadruplex arrangement terminating in a well defined thymine tetrad at the 3′-end. The detailed picture of the hydration pattern reveals LNA-specific features in the solvent distribution. Interestingly, two closely packed quadruplexes are present in the asymmetric unit. They face one another with their 3′-ends giving rise to a compact higher-order structure. This new assembly suggests a possible way in which sequential quadruplexes can be disposed in the crowded cell environment. Furthermore, as the formation of ordered structures by molecular self-assembly is an effective strategy to obtain nanostructures, this study could open the way to the design of a new class of LNA-based building blocks for nanotechnology.

Studies Toward the Synthesis of Phenylacetylene Macrocycle Based Rotaxane Precursors as Building Blocks for Organic Nanotubes

2012 ◽  
Vol 2012 (27) ◽  
pp. 5335-5349 ◽  
Author(s):  
Katy Cantin ◽  
Antoine Lafleur-Lambert ◽  
Philippe Dufour ◽  
Jean-François Morin
Keyword(s):  
Building Blocks ◽  
Organic Nanotubes

Photochemical Evolution of Interstellar/Precometary Organic Material

1997 ◽  
Vol 161 ◽  
pp. 23-47 ◽  
Author(s):  
Louis J. Allamandola ◽  
Max P. Bernstein ◽  
Scott A. Sandford
Keyword(s):  
Origin Of Life ◽  
Building Blocks ◽  
Complex Species ◽  
Infrared Observations ◽  
Interstellar Ice ◽  
Polycyclic Aromatic ◽  
Ultraviolet Photolysis ◽  
The Origin Of Life ◽  
Simple Molecules ◽  
Complex Organic

AbstractInfrared observations, combined with realistic laboratory simulations, have revolutionized our understanding of interstellar ice and dust, the building blocks of comets. Since comets are thought to be a major source of the volatiles on the primative earth, their organic inventory is of central importance to questions concerning the origin of life. Ices in molecular clouds contain the very simple molecules H2O, CH3OH, CO, CO2, CH4, H2, and probably some NH3and H2CO, as well as more complex species including nitriles, ketones, and esters. The evidence for these, as well as carbonrich materials such as polycyclic aromatic hydrocarbons (PAHs), microdiamonds, and amorphous carbon is briefly reviewed. This is followed by a detailed summary of interstellar/precometary ice photochemical evolution based on laboratory studies of realistic polar ice analogs. Ultraviolet photolysis of these ices produces H2, H2CO, CO2, CO, CH4, HCO, and the moderately complex organic molecules: CH3CH2OH (ethanol), HC(= O)NH2(formamide), CH3C(= O)NH2(acetamide), R-CN (nitriles), and hexamethylenetetramine (HMT, C6H12N4), as well as more complex species including polyoxymethylene and related species (POMs), amides, and ketones. The ready formation of these organic species from simple starting mixtures, the ice chemistry that ensues when these ices are mildly warmed, plus the observation that the more complex refractory photoproducts show lipid-like behavior and readily self organize into droplets upon exposure to liquid water suggest that comets may have played an important role in the origin of life.

Laboratory and in-situ analysis of comet dust

1988 ◽  
Vol 46 ◽  
pp. 8-9
Author(s):  
D.E. Brownlee ◽  
A.L. Albee
Keyword(s):  
Electron Microscopy ◽  
Solar System ◽  
Laboratory Study ◽  
Isotopic Analysis ◽  
Building Blocks ◽  
Sem Analysis ◽  
Early Solar System ◽  
Cometary Material ◽  
Comet Dust

Comets are primitive, kilometer-sized bodies that formed in the outer regions of the solar system. Composed of ice and dust, comets are generally believed to be relic building blocks of the outer solar system that have been preserved at cryogenic temperatures since the formation of the Sun and planets. The analysis of cometary material is particularly important because the properties of cometary material provide direct information on the processes and environments that formed and influenced solid matter both in the early solar system and in the interstellar environments that preceded it.The first direct analyses of proven comet dust were made during the Soviet and European spacecraft encounters with Comet Halley in 1986. These missions carried time-of-flight mass spectrometers that measured mass spectra of individual micron and smaller particles. The Halley measurements were semi-quantitative but they showed that comet dust is a complex fine-grained mixture of silicates and organic material. A full understanding of comet dust will require detailed morphological, mineralogical, elemental and isotopic analysis at the finest possible scale. Electron microscopy and related microbeam techniques will play key roles in the analysis. The present and future of electron microscopy of comet samples involves laboratory study of micrometeorites collected in the stratosphere, in-situ SEM analysis of particles collected at a comet and laboratory study of samples collected from a comet and returned to the Earth for detailed study.

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