Combinatorial and Automated Synthesis of Phosphodiester Galactosyl Cluster on Solid Support by Click Chemistry Assisted by Microwaves

2008 ◽  
Vol 73 (15) ◽  
pp. 6014-6017 ◽  
Author(s):  
Gwladys Pourceau ◽  
Albert Meyer ◽  
Jean-Jacques Vasseur ◽  
François Morvan
Keyword(s):  
Click Chemistry ◽  
Solid Support ◽  
Automated Synthesis

Folding of phosphodiester-linked donor-acceptor oligomers into supramolecular nanotubes in water

2021 ◽  
Author(s):  
Kevan Perez de Carvasal ◽  
Nesrine Aissaoui ◽  
Gérard Vergoten ◽  
Gaetan Bellot ◽  
Jean-Jacques Vasseur ◽  
...  
Keyword(s):  
Solid Support ◽  
Automated Synthesis ◽  
Donor Acceptor ◽  
Naphthalene Tetracarboxylic Diimide

Inspired by the automated synthesis of DNA on solid support, electron-rich dialkxoynaphthalene (DAN) donor and electron-deficient –naphthalene-tetracarboxylic diimide (NDI) acceptor, amphiphilic foldamers have been synthesised from their respective phosphoramidite building...

Reductive Alkylation and Sequential Reductive Alkylation-Click Chemistry for On-Solid-Support Modification of Pyrrolidinyl Peptide Nucleic Acid

2013 ◽  
Vol 24 (4) ◽  
pp. 614-625 ◽  
Author(s):  
Boonsong Ditmangklo ◽  
Chalothorn Boonlua ◽  
Chaturong Suparpprom ◽  
Tirayut Vilaivan
Keyword(s):  
Nucleic Acid ◽  
Click Chemistry ◽  
Peptide Nucleic Acid ◽  
Solid Support ◽  
Reductive Alkylation

Rapid automated synthesis via diisopropyl phosphoramidite in situ activation. Chemical synthesis and cloning of a calmodulin gene

1986 ◽  
Vol 64 (6) ◽  
pp. 548-555 ◽  
Author(s):  
G. Alvarado-Urbina ◽  
R. Chiarello ◽  
D. Roberts ◽  
G. Vilain ◽  
F. Jurik ◽  
...  
Keyword(s):  
Amino Acids ◽  
Chemical Synthesis ◽  
Solid Support ◽  
Automated Synthesis ◽  
Dna Fragments ◽  
Cleavage Sites ◽  
Gene Coding ◽  
In Situ Activation ◽  
Restriction Endonuclease Cleavage

A gene coding for a calmodulin was synthesized and cloned. The chemical synthesis of the gene, coding for 149 amino acids, was achieved by the enzymatic ligation of 61 chemically synthesized DNA fragments. The DNA fragments were synthesized using a solid support with a diisopropyl phosphoramidite intermediate and in situ activation. The automated standard cycle time was 10 min/addition. The synthesizer was designed and constructed from inexpensive, readily available parts and controlled by a Commodore 64 computer. The gene possesses 27 unique, regularly spaced, restriction endonuclease cleavage sites to facilitate gene mutagenesis.

Facile one-step solid-phase synthesis of multitopic organic–DNA hybrids via “click” chemistry

2014 ◽  
Vol 5 (3) ◽  
pp. 1091-1096 ◽  
Author(s):  
Ryan V. Thaner ◽  
Ibrahim Eryazici ◽  
Omar K. Farha ◽  
Chad A. Mirkin ◽  
SonBinh T. Nguyen
Keyword(s):  
Click Chemistry ◽  
Small Molecule ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Support ◽  
One Pot ◽  
Phase Synthesis ◽  
One Step

Small molecule–DNA hybrids can be synthesized in a one-pot fashion and in good yields by coupling multiazide cores to alkyne-modified DNAs on a solid support using click chemistry.

scholarly journals Automated glycan assembly of xyloglucan oligosaccharides

2016 ◽  
Vol 14 (1) ◽  
pp. 309-313 ◽  
Author(s):  
Pietro Dallabernardina ◽  
Frank Schuhmacher ◽  
Peter H. Seeberger ◽  
Fabian Pfrengle
Keyword(s):  
Building Blocks ◽  
Solid Support ◽  
Automated Synthesis ◽  
Linear Assembly

We report the automated synthesis of oligosaccharide fragments related to the hemicellulose xyloglucan based on the linear assembly of mono- and disaccharide building blocks on solid support.

Azide Solid Support for 3′-Conjugation of Oligonucleotides and Their Circularization by Click Chemistry

2009 ◽  
Vol 74 (17) ◽  
pp. 6837-6842 ◽  
Author(s):  
Gwladys Pourceau ◽  
Albert Meyer ◽  
Jean-Jacques Vasseur ◽  
François Morvan
Keyword(s):  
Click Chemistry ◽  
Solid Support

scholarly journals Chemical assay-guided natural product isolation via solid-supported chemodosimetric fluorescent probe

2015 ◽  
Vol 6 (5) ◽  
pp. 2806-2811 ◽  
Author(s):  
Hongjun Jeon ◽  
Chaemin Lim ◽  
Ji Min Lee ◽  
Sanghee Kim
Keyword(s):  
Click Chemistry ◽  
Natural Product ◽  
Fluorescent Probe ◽  
Solid Support ◽  
Chemical Assay

The fusion of click chemistry, fluorogenic chemodosimetry and a solid support offers advantages in identifying compounds in complex natural product mixtures.

Microwave-Assisted ‘Click’ Chemistry on Solid Support

Synfacts ◽  
2006 ◽  
Vol 2006 (9) ◽  
pp. 0965-0965
Author(s):  
F. Morvan ◽  
C. Bouillon ◽  
A. Meyer ◽  
S. Vidal ◽  
A. Jochum ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Solid Support ◽  
Microwave Assisted
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