scholarly journals Automated glycan assembly of xyloglucan oligosaccharides

2016 ◽  
Vol 14 (1) ◽  
pp. 309-313 ◽  
Author(s):  
Pietro Dallabernardina ◽  
Frank Schuhmacher ◽  
Peter H. Seeberger ◽  
Fabian Pfrengle
Keyword(s):  
Building Blocks ◽  
Solid Support ◽  
Automated Synthesis ◽  
Linear Assembly

We report the automated synthesis of oligosaccharide fragments related to the hemicellulose xyloglucan based on the linear assembly of mono- and disaccharide building blocks on solid support.

Automated glycopeptide assembly by combined solid-phase peptide and oligosaccharide synthesis

2014 ◽  
Vol 50 (15) ◽  
pp. 1851-1853 ◽  
Author(s):  
Mattan Hurevich ◽  
Peter H. Seeberger
Keyword(s):  
Amino Acid ◽  
Solid Phase ◽  
Building Blocks ◽  
Solid Support ◽  
Automated Synthesis ◽  
Oligosaccharide Synthesis ◽  
Polystyrene Beads ◽  
Single Instrument

Automated synthesis of glycopeptides was achieved using monosaccharide and amino acid building blocks. Using polystyrene beads equipped with photo-labile linker as solid support, all synthetic manipulations were performed using a single instrument.

Fully Automated Parallel Oligonucleotide Synthesizer

2001 ◽  
Vol 66 (8) ◽  
pp. 1299-1314 ◽  
Author(s):  
Michal Lebl ◽  
Christine Burger ◽  
Brett Ellman ◽  
David Heiner ◽  
Georges Ibrahim ◽  
...  
Keyword(s):  
Solid Phase ◽  
Building Blocks ◽  
Solid Support ◽  
Continuous Operation ◽  
Gear Pump ◽  
Oligonucleotide Synthesis ◽  
Center Of Rotation ◽  
Microtiter Plates ◽  
The Individual ◽  
Design And Construction

Design and construction of automated synthesizers using the tilted plate centrifugation technology is described. Wash solutions and reagents common to all synthesized species are delivered automatically through a 96-channel distributor connected to a gear pump through two four-port selector valves. Building blocks and other specific reagents are delivered automatically through banks of solenoid valves, positioned over the individual wells of the microtiterplate. These instruments have the following capabilities: Parallel solid-phase oligonucleotide synthesis in the wells of polypropylene microtiter plates, which are slightly tilted down towards the center of rotation, thus generating a pocket in each well, in which the solid support is collected during centrifugation, while the liquid is expelled from the wells. Eight microtiterplates are processed simultaneously, providing thus a synthesizer with a capacity of 768 parallel syntheses. The instruments are capable of unattended continuous operation, providing thus a capacity of over two millions 20-mer oligonucleotides in a year.

scholarly journals An aza-Diels–Alder route to quinoline-based unnatural amino acids and polypeptide surrogates

RSC Advances ◽  
2021 ◽  
Vol 11 (23) ◽  
pp. 14132-14139
Author(s):  
M. J. Umerani ◽  
H. Yang ◽  
P. Pratakshya ◽  
J. S. Nowick ◽  
A. A. Gorodetsky
Keyword(s):  
Amino Acids ◽  
Unnatural Amino Acids ◽  
Building Blocks ◽  
Solid Support ◽  
Diels Alder

The synthesis of quinoline-based unnatural amino acids and the subsequent preparation of polypeptide surrogates from these building blocks on solid support.

scholarly journals Automated glycan assembly using the Glyconeer 2.1 synthesizer

2017 ◽  
Vol 114 (17) ◽  
pp. E3385-E3389 ◽  
Author(s):  
Heung Sik Hahm ◽  
Mark K. Schlegel ◽  
Mattan Hurevich ◽  
Steffen Eller ◽  
Frank Schuhmacher ◽  
...  
Keyword(s):  
Quality Control ◽  
Peptide Synthesis ◽  
Medical Practice ◽  
Building Blocks ◽  
Solid Support ◽  
Biological Research ◽  
Structure Activity Relationships ◽  
Rapid Access ◽  
Structure Activity ◽  
Control Protocols

Reliable and rapid access to defined biopolymers by automated DNA and peptide synthesis has fundamentally altered biological research and medical practice. Similarly, the procurement of defined glycans is key to establishing structure–activity relationships and thereby progress in the glycosciences. Here, we describe the rapid assembly of oligosaccharides using the commercially available Glyconeer 2.1 automated glycan synthesizer, monosaccharide building blocks, and a linker-functionalized polystyrene solid support. Purification and quality-control protocols for the oligosaccharide products have been standardized. Synthetic glycans prepared in this way are useful reagents as the basis for glycan arrays, diagnostics, and carbohydrate-based vaccines.

Combinatorial and Automated Synthesis of Phosphodiester Galactosyl Cluster on Solid Support by Click Chemistry Assisted by Microwaves

2008 ◽  
Vol 73 (15) ◽  
pp. 6014-6017 ◽  
Author(s):  
Gwladys Pourceau ◽  
Albert Meyer ◽  
Jean-Jacques Vasseur ◽  
François Morvan
Keyword(s):  
Click Chemistry ◽  
Solid Support ◽  
Automated Synthesis

Folding of phosphodiester-linked donor-acceptor oligomers into supramolecular nanotubes in water

2021 ◽  
Author(s):  
Kevan Perez de Carvasal ◽  
Nesrine Aissaoui ◽  
Gérard Vergoten ◽  
Gaetan Bellot ◽  
Jean-Jacques Vasseur ◽  
...  
Keyword(s):  
Solid Support ◽  
Automated Synthesis ◽  
Donor Acceptor ◽  
Naphthalene Tetracarboxylic Diimide

Inspired by the automated synthesis of DNA on solid support, electron-rich dialkxoynaphthalene (DAN) donor and electron-deficient –naphthalene-tetracarboxylic diimide (NDI) acceptor, amphiphilic foldamers have been synthesised from their respective phosphoramidite building...

scholarly journals Modular automated solid phase synthesis of dermatan sulfate oligosaccharides

2014 ◽  
Vol 50 (15) ◽  
pp. 1875-1877 ◽  
Author(s):  
Jeyakumar Kandasamy ◽  
Frank Schuhmacher ◽  
Heung Sik Hahm ◽  
James C. Klein ◽  
Peter H. Seeberger
Keyword(s):  
Solid Phase Synthesis ◽  
Dermatan Sulfate ◽  
Solid Phase ◽  
Building Blocks ◽  
Automated Synthesis ◽  
Phase Synthesis ◽  
Iduronic Acid

Orthogonally protected d-galactosamine and l-iduronic acid building blocks and a photo-cleavable linker are instrumental for the automated synthesis of dermatan sulfate oligosaccharides.

A Novel, Fast and Efficient One-Pot Three-Component Procedure for the Preparation of New Imidazolidinone Derivatives from Isocyanide, Aldehyde and Urea

2019 ◽  
Vol 21 (9) ◽  
pp. 646-651
Author(s):  
Hamidreza Safaei ◽  
Neda Firoozi ◽  
Mahboobeh Zebarjadian ◽  
Seyed Ali Jehbez ◽  
Maryam Safaei
Keyword(s):  
Green Chemistry ◽  
Ammonium Chloride ◽  
Good Yield ◽  
Building Blocks ◽  
Inorganic Compound ◽  
Automated Synthesis ◽  
Complex Structures ◽  
Atom Economy ◽  
One Pot ◽  
Straightforward Method

Background: Multicomponent processes have played powerful roles in achieving complex structures, which are also aligned with green chemistry. Thus, MCRs have attracted considerable interest due to their atom economy, simple experimental procedures, automated synthesis, convenience and synthetic efficiency. Isocyanides are one of the crucial starting material in designing MCRs methods. They are unique building blocks in many cycloaddition reactions since they are able to react with both nucleophiles and electrophiles at the same carbon. Furthermore, ammonium chloride is an inorganic compound that is highly soluble in water, inexpensive and commercially available. Solutions of ammonium chloride are mildly acidic and have been used in various reactions. Objective: This article focuses on design a convenient and straightforward method for assembling important scaffolds such imidazolidinones through one-pot three-component strategy. Conclusion: The straightforward and efficient one-pot three component method for the synthesis of 4-(cyclohexylmethylene)-5-phenylimidazolidin-2-one derivatives is described. This reaction exploits the formation of imine, which undergoes spontaneous intermolecular cycloaddition with isocyanide, and generates the desired products in a good yield.

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