Design, Synthesis, and Biochemical Evaluation of 1,5,6,7-Tetrahydro-6,7-dioxo-9-d-Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase

Mark Cushman; Guangyi Jin; Boris Illarionov; Markus Fischer; Rudolf Ladenstein; Adelbert Bacher

doi:10.1021/jo051332v

Design, Synthesis, and Biochemical Evaluation of 1,5,6,7-Tetrahydro-6,7-dioxo-9-d-Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase

The Journal of Organic Chemistry ◽

10.1021/jo051332v ◽

2005 ◽

Vol 70 (20) ◽

pp. 8162-8170 ◽

Cited By ~ 22

Author(s):

Mark Cushman ◽

Guangyi Jin ◽

Boris Illarionov ◽

Markus Fischer ◽

Rudolf Ladenstein ◽

...

Keyword(s):

Design Synthesis ◽

Lumazine Synthase ◽

Alkyl Phosphate ◽

Biochemical Evaluation

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Design, Synthesis, and Biochemical Evaluation of 1,5,6,7-Tetrahydro-6,7-dioxo-9-D-Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase.

ChemInform ◽

10.1002/chin.200552189 ◽

2005 ◽

Vol 36 (52) ◽

Author(s):

Mark Cushman ◽

Guangyi Jin ◽

Boris Illarionov ◽

Markus Fischer ◽

Rudolf Ladenstein ◽

...

Keyword(s):

Design Synthesis ◽

Lumazine Synthase ◽

Alkyl Phosphate ◽

Biochemical Evaluation

Download Full-text

Design, Synthesis, and Biochemical Evaluation of 1,5,6,7-Tetrahydro-6,7-dioxo-9-d-Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase.

The Journal of Organic Chemistry ◽

10.1021/jo056032s ◽

2005 ◽

Vol 70 (22) ◽

pp. 9092-9092 ◽

Cited By ~ 1

Author(s):

Mark Cushman ◽

Guangyi Jin ◽

Thota Sambaiah ◽

Boris Illarionov ◽

Markus Fischer ◽

...

Keyword(s):

Design Synthesis ◽

Lumazine Synthase ◽

Alkyl Phosphate ◽

Biochemical Evaluation

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A New Series ofN-[2,4-Dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic Acid Derivatives as Inhibitors of Lumazine Synthase and Riboflavin Synthase: Design, Synthesis, Biochemical Evaluation, Crystallography, and Mechanistic Implications

The Journal of Organic Chemistry ◽

10.1021/jo702631a ◽

2008 ◽

Vol 73 (7) ◽

pp. 2715-2724 ◽

Cited By ~ 17

Author(s):

Yanlei Zhang ◽

Boris Illarionov ◽

Ekaterina Morgunova ◽

Guangyi Jin ◽

Adelbert Bacher ◽

...

Keyword(s):

Design Synthesis ◽

Lumazine Synthase ◽

Biochemical Evaluation

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Design, Synthesis, and Evaluation of 9-d-Ribitylamino-1,3,7,9-tetrahydro-2,6,8-purinetriones Bearing Alkyl Phosphate and α,α-Difluorophosphonate Substituents as Inhibitors of Riboflavin Synthase and Lumazine Synthase

The Journal of Organic Chemistry ◽

10.1021/jo030278k ◽

2004 ◽

Vol 69 (3) ◽

pp. 601-612 ◽

Cited By ~ 37

Author(s):

Mark Cushman ◽

Thota Sambaiah ◽

Guangyi Jin ◽

Boris Illarionov ◽

Markus Fischer ◽

...

Keyword(s):

Design Synthesis ◽

Lumazine Synthase ◽

Alkyl Phosphate

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A New Series of 3-Alkyl Phosphate Derivatives of 4,5,6,7-Tetrahydro-1-d-ribityl-1H-pyrazolo[3,4-d]pyrimidinedione as Inhibitors of Lumazine Synthase: Design, Synthesis, and Evaluation

The Journal of Organic Chemistry ◽

10.1021/jo070982r ◽

2007 ◽

Vol 72 (19) ◽

pp. 7176-7184 ◽

Cited By ~ 17

Author(s):

Yanlei Zhang ◽

Guangyi Jin ◽

Boris Illarionov ◽

Adelbert Bacher ◽

Markus Fischer ◽

...

Keyword(s):

Design Synthesis ◽

Lumazine Synthase ◽

Alkyl Phosphate ◽

Derivatives Of

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Design, Synthesis, and Biochemical Evaluation of Novel Cruzain Inhibitors with Potential Application in the Treatment of Chagas′ Disease.

ChemInform ◽

10.1002/chin.200651217 ◽

2006 ◽

Vol 37 (51) ◽

Author(s):

Rogelio Siles ◽

Shen-En Chen ◽

Ming Zhou ◽

Kevin G. Pinney ◽

Mary Lynn Trawick

Keyword(s):

Chagas Disease ◽

Potential Application ◽

Design Synthesis ◽

Biochemical Evaluation ◽

Cruzain Inhibitors

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Design, Synthesis, and Evaluation of Acyclic C-Nucleoside and N-Methylated Derivatives of the Ribitylaminopyrimidine Substrate of Lumazine Synthase as Potential Enzyme Inhibitors and Mechanistic Probes.

ChemInform ◽

10.1002/chin.200508222 ◽

2005 ◽

Vol 36 (8) ◽

Author(s):

Jinhua Chen ◽

Thota Sambaiah ◽

Boris Illarionov ◽

Markus Fischer ◽

Adelbert Bacher ◽

...

Keyword(s):

Enzyme Inhibitors ◽

Design Synthesis ◽

Lumazine Synthase ◽

Derivatives Of

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Molecular Modelling, Design, Synthesis and Biochemical Evaluation of a Range of Non-Steroidal Thiosemicarbazone-Based Inhibitors of Estrone Sulfatase (ES) - A Potential Insight into the Action of a Range of Allosteric Inhibitors of ES

Letters in Drug Design & Discovery ◽

10.2174/157018011797200821 ◽

2011 ◽

Vol 8 (9) ◽

pp. 889-896

Author(s):

Amit Kumar ◽

Sukriti Singh ◽

Balkrishna Bhamare ◽

Kruti Shah ◽

Pallav S. Shah ◽

...

Keyword(s):

Molecular Modelling ◽

Allosteric Inhibitors ◽

Design Synthesis ◽

Estrone Sulfatase ◽

Biochemical Evaluation ◽

Insight Into

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Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.02.018 ◽

2019 ◽

Vol 167 ◽

pp. 357-366 ◽

Cited By ~ 4

Author(s):

Felipe A. Calil ◽

Juliana S. David ◽

Estela R.C. Chiappetta ◽

Fernando Fumagalli ◽

Rodrigo B. Mello ◽

...

Keyword(s):

Schistosoma Mansoni ◽

Dihydroorotate Dehydrogenase ◽

Selective Inhibitors ◽

Design Synthesis ◽

Biochemical Evaluation

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Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.10.050 ◽

2018 ◽

Vol 143 ◽

pp. 1543-1552 ◽

Cited By ~ 12

Author(s):

Simone Carradori ◽

Francesco Ortuso ◽

Anél Petzer ◽

Donatella Bagetta ◽

Celeste De Monte ◽

...

Keyword(s):

Design Synthesis ◽

Biochemical Evaluation

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