A New Series ofN-[2,4-Dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic Acid Derivatives as Inhibitors of Lumazine Synthase and Riboflavin Synthase:  Design, Synthesis, Biochemical Evaluation, Crystallography, and Mechanistic Implications

Yanlei Zhang; Boris Illarionov; Ekaterina Morgunova; Guangyi Jin; Adelbert Bacher; Markus Fischer; Rudolf Ladenstein; Mark Cushman

doi:10.1021/jo702631a

A New Series ofN-[2,4-Dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic Acid Derivatives as Inhibitors of Lumazine Synthase and Riboflavin Synthase: Design, Synthesis, Biochemical Evaluation, Crystallography, and Mechanistic Implications

The Journal of Organic Chemistry ◽

10.1021/jo702631a ◽

2008 ◽

Vol 73 (7) ◽

pp. 2715-2724 ◽

Cited By ~ 17

Author(s):

Yanlei Zhang ◽

Boris Illarionov ◽

Ekaterina Morgunova ◽

Guangyi Jin ◽

Adelbert Bacher ◽

...

Keyword(s):

Design Synthesis ◽

Lumazine Synthase ◽

Biochemical Evaluation

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Design, Synthesis, and Biochemical Evaluation of 1,5,6,7-Tetrahydro-6,7-dioxo-9-d-Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase

The Journal of Organic Chemistry ◽

10.1021/jo051332v ◽

2005 ◽

Vol 70 (20) ◽

pp. 8162-8170 ◽

Cited By ~ 22

Author(s):

Mark Cushman ◽

Guangyi Jin ◽

Boris Illarionov ◽

Markus Fischer ◽

Rudolf Ladenstein ◽

...

Keyword(s):

Design Synthesis ◽

Lumazine Synthase ◽

Alkyl Phosphate ◽

Biochemical Evaluation

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Design, Synthesis, and Biochemical Evaluation of 1,5,6,7-Tetrahydro-6,7-dioxo-9-D-Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase.

ChemInform ◽

10.1002/chin.200552189 ◽

2005 ◽

Vol 36 (52) ◽

Author(s):

Mark Cushman ◽

Guangyi Jin ◽

Boris Illarionov ◽

Markus Fischer ◽

Rudolf Ladenstein ◽

...

Keyword(s):

Design Synthesis ◽

Lumazine Synthase ◽

Alkyl Phosphate ◽

Biochemical Evaluation

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Design, Synthesis, and Biochemical Evaluation of 1,5,6,7-Tetrahydro-6,7-dioxo-9-d-Ribitylaminolumazines Bearing Alkyl Phosphate Substituents as Inhibitors of Lumazine Synthase and Riboflavin Synthase.

The Journal of Organic Chemistry ◽

10.1021/jo056032s ◽

2005 ◽

Vol 70 (22) ◽

pp. 9092-9092 ◽

Cited By ~ 1

Author(s):

Mark Cushman ◽

Guangyi Jin ◽

Thota Sambaiah ◽

Boris Illarionov ◽

Markus Fischer ◽

...

Keyword(s):

Design Synthesis ◽

Lumazine Synthase ◽

Alkyl Phosphate ◽

Biochemical Evaluation

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Design, Synthesis, and Biochemical Evaluation of Novel Cruzain Inhibitors with Potential Application in the Treatment of Chagas′ Disease.

ChemInform ◽

10.1002/chin.200651217 ◽

2006 ◽

Vol 37 (51) ◽

Author(s):

Rogelio Siles ◽

Shen-En Chen ◽

Ming Zhou ◽

Kevin G. Pinney ◽

Mary Lynn Trawick

Keyword(s):

Chagas Disease ◽

Potential Application ◽

Design Synthesis ◽

Biochemical Evaluation ◽

Cruzain Inhibitors

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Design, Synthesis, and Evaluation of Acyclic C-Nucleoside and N-Methylated Derivatives of the Ribitylaminopyrimidine Substrate of Lumazine Synthase as Potential Enzyme Inhibitors and Mechanistic Probes.

ChemInform ◽

10.1002/chin.200508222 ◽

2005 ◽

Vol 36 (8) ◽

Author(s):

Jinhua Chen ◽

Thota Sambaiah ◽

Boris Illarionov ◽

Markus Fischer ◽

Adelbert Bacher ◽

...

Keyword(s):

Enzyme Inhibitors ◽

Design Synthesis ◽

Lumazine Synthase ◽

Derivatives Of

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Molecular Modelling, Design, Synthesis and Biochemical Evaluation of a Range of Non-Steroidal Thiosemicarbazone-Based Inhibitors of Estrone Sulfatase (ES) - A Potential Insight into the Action of a Range of Allosteric Inhibitors of ES

Letters in Drug Design & Discovery ◽

10.2174/157018011797200821 ◽

2011 ◽

Vol 8 (9) ◽

pp. 889-896

Author(s):

Amit Kumar ◽

Sukriti Singh ◽

Balkrishna Bhamare ◽

Kruti Shah ◽

Pallav S. Shah ◽

...

Keyword(s):

Molecular Modelling ◽

Allosteric Inhibitors ◽

Design Synthesis ◽

Estrone Sulfatase ◽

Biochemical Evaluation ◽

Insight Into

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Ligand-based design, synthesis and biochemical evaluation of potent and selective inhibitors of Schistosoma mansoni dihydroorotate dehydrogenase

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.02.018 ◽

2019 ◽

Vol 167 ◽

pp. 357-366 ◽

Cited By ~ 4

Author(s):

Felipe A. Calil ◽

Juliana S. David ◽

Estela R.C. Chiappetta ◽

Fernando Fumagalli ◽

Rodrigo B. Mello ◽

...

Keyword(s):

Schistosoma Mansoni ◽

Dihydroorotate Dehydrogenase ◽

Selective Inhibitors ◽

Design Synthesis ◽

Biochemical Evaluation

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Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.10.050 ◽

2018 ◽

Vol 143 ◽

pp. 1543-1552 ◽

Cited By ~ 12

Author(s):

Simone Carradori ◽

Francesco Ortuso ◽

Anél Petzer ◽

Donatella Bagetta ◽

Celeste De Monte ◽

...

Keyword(s):

Design Synthesis ◽

Biochemical Evaluation

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Design, synthesis, biochemical evaluation, radiolabeling and in vivo imaging with high affinity class-IIa histone deacetylase inhibitor for molecular imaging and targeted therapy

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.114011 ◽

2021 ◽

pp. 114011

Author(s):

Nashaat Turkman ◽

Daxing Liu ◽

Isabella Pirola

Keyword(s):

Targeted Therapy ◽

Molecular Imaging ◽

Histone Deacetylase ◽

In Vivo Imaging ◽

Histone Deacetylase Inhibitor ◽

Design Synthesis ◽

High Affinity ◽

Deacetylase Inhibitor ◽

Biochemical Evaluation

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Design, synthesis, and biochemical evaluation of novel αvβ3 integrin ligands

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2004.06.017 ◽

2004 ◽

Vol 14 (17) ◽

pp. 4553-4555 ◽

Cited By ~ 3

Author(s):

Juan Jose Marugan ◽

Kristin D Haslow ◽

Carl Crysler

Keyword(s):

Αvβ3 Integrin ◽

Design Synthesis ◽

Biochemical Evaluation ◽

Integrin Ligands

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