Stereoselective Synthesis of Constrained Azacyclic Hydroxyethylene Isosteres as Aspartic Protease Inhibitors: Dipolar Cycloaddition and Related Methodologies toward Branched Pyrrolidine and Pyrrolidinone Carboxylic Acids

2005 ◽  
Vol 70 (17) ◽  
pp. 6746-6756 ◽  
Author(s):  
Stephen Hanessian ◽  
Hongying Yun ◽  
Yihua Hou ◽  
Marina Tintelnot-Blomley
Keyword(s):  
Protease Inhibitors ◽  
Carboxylic Acids ◽  
Stereoselective Synthesis ◽  
Aspartic Protease ◽  
Dipolar Cycloaddition

ChemInform Abstract: Potent HIV-1 Protease Inhibitors: Stereoselective Synthesis of a Dipeptide Mimic.

ChemInform ◽  
2010 ◽  
Vol 24 (22) ◽  
pp. no-no
Author(s):  
A. K. GHOSH ◽  
S. P. MCKEE ◽  
W. J. THOMPSON ◽  
P. L. DARKE ◽  
J. C. ZUGAY
Keyword(s):  
Protease Inhibitors ◽  
Stereoselective Synthesis ◽  
Hiv 1

Synthesis ofexo-3-Amino-7-azabicyclo[2.2.1]heptanes as a Class of Malarial Aspartic Protease Inhibitors: Exploration of Two Binding Pockets

2009 ◽  
Vol 2009 (11) ◽  
pp. 1707-1719 ◽  
Author(s):  
Martina Zürcher ◽  
Fraser Hof ◽  
Luzi Barandun ◽  
Andri Schütz ◽  
W. Bernd Schweizer ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Aspartic Protease ◽  
Binding Pockets

1,3-Dipolar Cycloaddition of Isatin-Derived Azomethine Ylides with 2H-Azirines: Stereoselective Synthesis of 1,3-Diazaspiro[bicyclo[3.1.0]hexane]oxindoles

2019 ◽  
Vol 84 (7) ◽  
pp. 4273-4281 ◽  
Author(s):  
Anikó Angyal ◽  
András Demjén ◽  
Veronika Harmat ◽  
János Wölfling ◽  
László G. Puskás ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Azomethine Ylides ◽  
Dipolar Cycloaddition
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