Organic syntheses by means of metal complexes. V. Reactions of olefins, carbon tetrachloride, and carbon monoxide catalyzed by metal carbonyls

1970 ◽  
Vol 35 (9) ◽  
pp. 2982-2986 ◽  
Author(s):  
Tosaku. Susuki ◽  
Jiro. Tsuji
Keyword(s):  
Carbon Monoxide ◽  
Carbon Tetrachloride ◽  
Metal Complexes ◽  
Metal Carbonyls ◽  
Organic Syntheses

Reductive Activation of Carbon Tetrachloride by Human Haemoglobin

1993 ◽  
Vol 21 (1) ◽  
pp. 57-64
Author(s):  
Roberta Ferrara ◽  
Michela Rezzadore ◽  
Stefano Cazzaro ◽  
Roberto Tolando ◽  
Maurizio Manno
Keyword(s):  
Carbon Monoxide ◽  
Carbon Tetrachloride ◽  
Anaerobic Incubation ◽  
Reductive Activation ◽  
Anaerobic Conditions ◽  
Prosthetic Group ◽  
Experimental Conditions ◽  
Human Haemoglobin ◽  
Reductive Metabolism

The reductive metabolism of carbon tetrachloride (CC14) by human haemoglobin (Hb) was observed in vitro by absolute absorption spectra recorded under anaerobic conditions. The following results were obtained: 1) a decrease of the 430nm peak typical of free reduced Hb (Hb2+); 2) the formation of a shoulder of absorbance, attributable to the production of a complex between Hb2+ and a metabolite of CC14 carbon monoxide (Hb-CO); and 3) the oxidation of some Hb2+ to methaemoglobin (Hb3+). The concentration of these three forms — Hb2+, Hb-CO and Hb3+ — during anaerobic incubation of Hb with CC14 was calculated algebraically from the absolute spectra. CO production was then calculated from the concentration of Hb-CO, using a suitable calibration curve. Interestingly, under identical experimental conditions, a substrate-dependent loss of Hb-derived haem, but not of Hb itself nor of haem-derived porphyrin fluorescence, was measured. Preliminary HPLC studies to clarify the discrepancy and, in particular, the role and fate of the haem group, showed two substrate-dependent modified haem products. The results indicate that human Hb is able to catalyse the reductive activation of CCl4, and suggest that, during the process, its prosthetic group haem may be modified by CC14 metabolites to products which maintain a tetrapyrrolic structure but are unable to react with pyridine.

Acetylenic derivatives of metal carbonyls. II. Carbon monoxide exchange with Co2(CO)6C2RR' complexes

1967 ◽  
Vol 6 (6) ◽  
pp. 1225-1228 ◽  
Author(s):  
Giuseppe Cetini ◽  
Olimpia Gambino ◽  
P. L. Stanghellini ◽  
Gian A. Vaglio
Keyword(s):  
Carbon Monoxide ◽  
Metal Carbonyls ◽  
Derivatives Of
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