Modified taxols. 3. Preparation and acylation of baccatin III

1986 ◽  
Vol 51 (16) ◽  
pp. 3239-3242 ◽  
Author(s):  
Neal F. Magri ◽  
David G. I. Kingston ◽  
Chote Jitrangsri ◽  
Thomas Piccariello
Keyword(s):  
Baccatin Iii

scholarly journals Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani

2013 ◽  
Vol 13 (1) ◽  
pp. 105 ◽  
Author(s):  
Balabhadrapatruni VSK Chakravarthi ◽  
Ramanathan Sujay ◽  
Gini C Kuriakose ◽  
Anjali A Karande ◽  
Chelliah Jayabaskaran
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Fusarium Solani ◽  
Cancer Cell Proliferation ◽  
Baccatin Iii ◽  
Proliferation And Apoptosis

A New Semisynthesis of Paclitaxel from Baccatin III

1999 ◽  
Vol 62 (7) ◽  
pp. 1068-1071 ◽  
Author(s):  
Erkan Baloglu ◽  
David G. I. Kingston
Keyword(s):  
Baccatin Iii

Development of a hazel cell culture-based paclitaxel and baccatin III production process on a benchtop scale

2015 ◽  
Vol 195 ◽  
pp. 93-102 ◽  
Author(s):  
Ana Gallego ◽  
Nicole Imseng ◽  
Mercedes Bonfill ◽  
Rosa M. Cusido ◽  
Javier Palazon ◽  
...  
Keyword(s):  
Cell Culture ◽  
Production Process ◽  
Baccatin Iii

scholarly journals A preliminary study of the taxane chemistry and natural history of the Mexican yew, Taxus globosa Schltdl.

2017 ◽  
pp. 119
Author(s):  
Melvin J. Shemluck ◽  
Eduardo Estrada ◽  
Robert Nicholson ◽  
Susan W. Brobst
Keyword(s):  
Natural History ◽  
Chemical Study ◽  
Morphological Comparison ◽  
Average Percentage ◽  
Baccatin Iii ◽  
History Of ◽  
Ecological Habitat ◽  
Preliminary Study ◽  
Taxus Globosa ◽  
Intrapopulational Variation

This paper represents a preliminary study of the botany, natural history and taxane chemistry of the Mexican yew, Taxus globosa Schltdl. Taxonomic history, morphological comparison to other North American species and ecological habitat are discussed. Chemical study involved leaf and twig material from forty-nine plants from three localities in Mexico. Levels of taxol, cephalomannine and baccatin III were determined by HPLC analysis. Intrapopulational variation was found to be very high while mean taxane levels for each of the three populations were very similar. The average percentage of taxol in leaves of T. globosa is higher than in all other species of Taxus (0.0121% dry wt.).

10-Deacetyl baccatin III dimethyl sulfoxide disolvate

2001 ◽  
Vol 57 (1) ◽  
pp. 64-65 ◽  
Author(s):  
James K. Harper ◽  
N. Kent Dalley ◽  
Anna E. Mulgrew ◽  
F. G. West ◽  
David M. Grant
Keyword(s):  
Dimethyl Sulfoxide ◽  
Baccatin Iii

An efficient semisynthesis of taxol from (3R,4S)-N-Benzoyl-3-[(t-butyldimethylsilyl)oxy]-4-phenyl-2-azetidinone and 7-(Triethylsilyl)baccatin III

1993 ◽  
Vol 3 (11) ◽  
pp. 2467-2470 ◽  
Author(s):  
Gunda I. Georg ◽  
Zacharia S. Cheruvallath ◽  
Geraldine C.B. Harriman ◽  
Michael Hepperle ◽  
Haeil Park
Keyword(s):  
Baccatin Iii

Variation of Taxane Content in Needles of Taxus x media Cultivars with Different Growth Characteristics

2006 ◽  
Vol 61 (9-10) ◽  
pp. 619-624 ◽  
Author(s):  
Xinkun Wang ◽  
Yinghua Huang ◽  
Andrew J. Mort ◽  
Yuhong Zeng ◽  
Charles G. Tauer ◽  
...  
Keyword(s):  
High Performance ◽  
Biomass Accumulation ◽  
Dry Weight ◽  
Growth Characteristics ◽  
Alternative Methods ◽  
Baccatin Iii ◽  
Fast Growing ◽  
Taxus X Media ◽  
Slow Growing ◽  
Group 1

AbstractNeedles from 17 different Taxus x media cultivars, belonging to 4 groups showing different growth characteristics, were analyzed using high performance liquid chromatography for their content of 10-deacetylbaccatin III, baccatin III, cephalomannine and paclitaxel (Taxol®). The 4 Taxus x media cultivar groups were: 1.) medium to fast growing and upright form; 2.) slow growing and upright form; 3.) fast growing and spreading form; and 4.) slow growing and spreading form. The purpose of this study was to identify yew cultivars of fast growth rate, upright growth and high taxane content in their needles. The highest content of paclitaxel was found in ‘Coleana’ of group 1 (378 μg/g of the extracted dry weight). Three cultivars in group 1, ‘Coleana’, ‘Stovekenii’ and ‘Hicksii’, make good candidates for taxane extraction because of their high paclitaxel and 10-deacetylbaccatin III content, fast biomass accumulation and upright growing form. They are also good starting materials to develop alternative methods for the production of paclitaxel and its analogous compounds through modern biotechnology approaches.

scholarly journals Dataset of Targeted Metabolite Analysis for Five Taxanes of Hellenic Taxus baccata L. Populations

Data ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 22
Author(s):  
Eleftheria Dalmaris ◽  
Evangelia V. Avramidou ◽  
Aliki Xanthopoulou ◽  
Filippos A. Aravanopoulos
Keyword(s):  
Natural Populations ◽  
Population Level ◽  
Primary Sources ◽  
Taxus Baccata ◽  
Metabolite Analysis ◽  
Data Set ◽  
Baccatin Iii ◽  
Significant Seasonal Variation ◽  
Increasing Demand ◽  
Selection Of

Novel primary sources of one of the world’s leading anticancer agent, paclitaxel, as well as of other antineoplastic taxanes such as 10-deacetylbaccatin-III, are needed to meet an increasing demand. Among the Taxus species the promise of Taxus baccata L. (European or English yew) has been documented. In this study, the metabolite analysis of two marginal T. baccata populations in Greece (Mt. Cholomon and Mt. Olympus), located at the southeastern edge of the species natural distribution, are being explored. A targeted liquid chromatography – mass spectrometry (LC-MS/MS) analysis was used to determine the content of 10-deacetylbaccatin III, baccatin III, 10-deacetyltaxol, paclitaxel and cephalomannine in the needles of each of the populations from three sampling periods (spring, summer and winter). This is the first survey to generate a taxane targeted metabolite data set, since it derives from Hellenic natural populations that have not been explored before. Furthermore, it has used an extensive sample design in order to evaluate chemodiversity at the population level. The analysis revealed significant levels of chemodiversity within and among the investigated populations and significant seasonal variation that could be exploited for the selection of superior germplasm native to Greece, for yew plantations and further exploitation which is necessary for the production of important taxanes.

ChemInform Abstract: 10-Deacetyl Baccatin III Dimethyl Sulfoxide Disolvate.

ChemInform ◽  
2010 ◽  
Vol 32 (22) ◽  
pp. no-no
Author(s):  
James K. Harper ◽  
N. Kent Dalley ◽  
Anna E. Mulgrew ◽  
F. G. West ◽  
David M. Grant
Keyword(s):  
Dimethyl Sulfoxide ◽  
Baccatin Iii
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