scholarly journals A preliminary study of the taxane chemistry and natural history of the Mexican yew, Taxus globosa Schltdl.

2017 ◽  
pp. 119
Author(s):  
Melvin J. Shemluck ◽  
Eduardo Estrada ◽  
Robert Nicholson ◽  
Susan W. Brobst

This paper represents a preliminary study of the botany, natural history and taxane chemistry of the Mexican yew, Taxus globosa Schltdl. Taxonomic history, morphological comparison to other North American species and ecological habitat are discussed. Chemical study involved leaf and twig material from forty-nine plants from three localities in Mexico. Levels of taxol, cephalomannine and baccatin III were determined by HPLC analysis. Intrapopulational variation was found to be very high while mean taxane levels for each of the three populations were very similar. The average percentage of taxol in leaves of T. globosa is higher than in all other species of Taxus (0.0121% dry wt.).

1986 ◽  
Vol 135 (5) ◽  
pp. 905-908 ◽  
Author(s):  
Daniel Dalton ◽  
Harvey Neiman ◽  
John T. Grayhack

Author(s):  
Mariam Soumare-Dicko ◽  
Neol Magloire Manga ◽  
Yacouba Cissoko ◽  
A Fofana ◽  
J Tine ◽  
...  

Glomerulopathy and other kidney disorders are frequent during the natural history of HIV infection even if their incidence decreased with HAART. They are almost always responsible of proteinuria and/or hematuria. We have conducted a preliminary study on the prevalence of proteinuria screened by urinary strip in PLWHIV followed up at the clinic of infectious diseases at Fann teaching hospital in Dakar. It was a prospective study from August 1st to October 30th, 2008. We enrolled all patients both indoor and outdoor positive for HIV presenting a proteinuria without concurrent urinary infection. We collected sociodemographic data, natural history, factors related to proteinuria and nephropathy. Data entering and analysis were done using Epi Info version 6.04 software. We have used Chi square test to compare qualitative variables and p<0.05 was set as significant threshold. A total of 100 patients were enrolled, the mean age was 43± 9.8 y/o in male and 39± 10 y/o in female. Females were predominant (sex ratio M/F is 0.5). All patients were infected by HIV1, they have been diagnosed at a late stage of immunodeficiency, fifty percent was taking HAART, and the majority using AZT +3TC+ EFV regimen. The prevalence of proteinuria was 47.0%. Factors significantly associated with proteinuria were : the gender ; CD4 count <350/mm3 ; viral load > 100000copies/mm3 ; BMI < 18.5kg/m2 ; Hemoglobin level < 8.5 g/dl, chemoprophylaxis with Cotrimoxazole  and WHO clinical stage 3 and 4. The frequency of nephropathy during HIV infection in infectious diseases ward of Fann in Dakar suggest to include screening with urinary strip in the initial and follow up checking of all patient infected by HIV. And in all cases favoring factors of this nephropathy should be corrected. Kidney biopsy could help for better studies.


2020 ◽  
Vol 43 ◽  
Author(s):  
Hannes Rakoczy

Abstract The natural history of our moral stance told here in this commentary reveals the close nexus of morality and basic social-cognitive capacities. Big mysteries about morality thus transform into smaller and more manageable ones. Here, I raise questions regarding the conceptual, ontogenetic, and evolutionary relations of the moral stance to the intentional and group stances and to shared intentionality.


2001 ◽  
Vol 120 (5) ◽  
pp. A128-A128 ◽  
Author(s):  
H MALATY ◽  
D GRAHAM ◽  
A ELKASABANY ◽  
S REDDY ◽  
S SRINIVASAN ◽  
...  

2001 ◽  
Vol 120 (5) ◽  
pp. A366-A366
Author(s):  
C MAZZEO ◽  
F AZZAROLI ◽  
A COLECCHIA ◽  
S DISILVIO ◽  
A DORMI ◽  
...  

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