Chiral synthesis via organoboranes. 18. Selective reductions. 43. Diisopinocampheylchloroborane as an excellent chiral reducing reagent for the synthesis of halo alcohols of high enantiomeric purity. A highly enantioselective synthesis of both optical isomers of Tomoxetine, Fluoxetine, and Nisoxetine

1988 ◽  
Vol 53 (13) ◽  
pp. 2916-2920 ◽  
Author(s):  
Morris Srebnik ◽  
P. V. Ramachandran ◽  
Herbert C. Brown
Keyword(s):  
Enantiomeric Purity ◽  
Enantioselective Synthesis ◽  
Optical Isomers ◽  
Chiral Synthesis

Enantioselective synthesis of the optical isomers of broad-spectrum orally active antifungal azoles, Sch 42538 and Sch 45012

1994 ◽  
Vol 4 (16) ◽  
pp. 2023-2028 ◽  
Author(s):  
Anil K. Saksena ◽  
Viyyoor M. Girijavallabhan ◽  
Raymond G. Lovey ◽  
Russell E. Pike ◽  
Jagdish A. Desai ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Enantioselective Synthesis ◽  
Optical Isomers ◽  
Orally Active

Enantioselective synthesis of an octahydroindolizine (indolizidine) alcohol using an enzymatic resolution

2017 ◽  
Vol 15 (14) ◽  
pp. 2953-2961 ◽  
Author(s):  
Jing Zhang ◽  
Rao Kolluri ◽  
Salvador G. Alvarez ◽  
Mark M. Irving ◽  
Rajinder Singh ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Chiral Synthesis ◽  
Enzymatic Resolution

A homo-chiral synthesis of (7R,8aS)-octahydro-5,5-dimethylindolizin-7-amine 8 and (7S,8aS)-octahydro-5,5-dimethylindolizin-7-ol 9, amine building blocks which have found applications within the pharmaceutical industry, is presented.

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