Enantioselective synthesis of an octahydroindolizine (indolizidine) alcohol using an enzymatic resolution

2017 ◽  
Vol 15 (14) ◽  
pp. 2953-2961 ◽  
Author(s):  
Jing Zhang ◽  
Rao Kolluri ◽  
Salvador G. Alvarez ◽  
Mark M. Irving ◽  
Rajinder Singh ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Chiral Synthesis ◽  
Enzymatic Resolution

A homo-chiral synthesis of (7R,8aS)-octahydro-5,5-dimethylindolizin-7-amine 8 and (7S,8aS)-octahydro-5,5-dimethylindolizin-7-ol 9, amine building blocks which have found applications within the pharmaceutical industry, is presented.

Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids

2019 ◽  
Author(s):  
Ming Shang ◽  
Karla S. Feu ◽  
Julien C. Vantourout ◽  
Lisa M. Barton ◽  
Heather L. Osswald ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Heterocyclic Compounds ◽  
Cross Coupling ◽  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Carbon Centers ◽  
Drug Candidates ◽  
Rapid Diversification ◽  
Directing Group ◽  
Compound Series

<div> <div> <div> <p>The union of two powerful transformations, directed C–H activation and decarboxylative cross-coupling, for the enantioselective synthesis of vicinally functionalized alkyl, carbocyclic, and heterocyclic compounds is described. Starting from simple carboxylic acid building blocks, this modular sequence exploits the residual directing group to access more than 50 scaffolds that would be otherwise extremely difficult to prepare. The tactical use of these two transformations accomplishes a formal vicinal difunctionalization of carbon centers in a way that is modular and thus amenable to rapid diversity incorporation. A simplification of routes to known preclinical drug candidates is presented along with the rapid diversification of an antimalarial compound series. </p> </div> </div> </div>

Enantioselective Synthesis of O-Methoxycarbonyl Cyanohydrins: Chiral Building Blocks Generated by Bifunctional Catalysis with BINOLAM-AlCl.

ChemInform ◽  
2006 ◽  
Vol 37 (33) ◽  
Author(s):  
Alejandro Baeza ◽  
Jesus Casas ◽  
Carmen Najera ◽  
Jose M. Sansano ◽  
Jose M. Saa
Keyword(s):  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Bifunctional Catalysis

Enantioselective Synthesis of 2,3-Dihydrofurans with Bifunctional Quinine/Squaramide Organocatalyst

2021 ◽  
Author(s):  
Zeynep Dilşad Susam ◽  
Merve Bozdemir ◽  
Gülsüm Gündoğdu ◽  
Cihangir Tanyeli
Keyword(s):  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Dicarbonyl Compounds ◽  
Sn2 Reactions

Asymmetric organocatalytic domino type Michael-SN2 reactions give access to enantiomerically enriched dihydrofuran derivatives that can be used as valuable chiral building blocks. A variety of α-bromonitroalkenes and 1,3-dicarbonyl compounds were...

scholarly journals Catalytic enantioselective synthesis of α-aryl α-hydrazino esters and amides

2020 ◽  
Vol 56 (43) ◽  
pp. 5823-5826
Author(s):  
Marta Velázquez ◽  
Saúl Alberca ◽  
Javier Iglesias-Sigüenza ◽  
Rosario Fernández ◽  
José M. Lassaletta ◽  
...  
Keyword(s):  
Building Blocks ◽  
Boronic Acids ◽  
Enantioselective Synthesis

Asymmetric 1,2-addition of aryl boronic acids to N-carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones affords α-aryl α-hydrazino esters/amides, key building blocks en route to artificial peptides.

Enantioselective Synthesis of 1,3-Dioxygen-substituted Chiral Building Blocks

Synlett ◽  
1994 ◽  
Vol 1994 (03) ◽  
pp. 199-200 ◽  
Author(s):  
Chris H. Senanayake ◽  
Robert D. Larsen ◽  
Timothy J. Bill ◽  
Ji Liu ◽  
Edward G. Corley ◽  
...  
Keyword(s):  
Building Blocks ◽  
Enantioselective Synthesis
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