Structure−Activity Relationships and Molecular Modeling Analysis of Flavonoids Binding to the Benzodiazepine Site of the Rat Brain GABAAReceptor Complex

Kim Dekermendjian; Pia Kahnberg; Michael-Robin Witt; Olov Sterner; Mogens Nielsen; Tommy Liljefors

doi:10.1021/jm991010h

Structure−Activity Relationships and Molecular Modeling Analysis of Flavonoids Binding to the Benzodiazepine Site of the Rat Brain GABAAReceptor Complex

Journal of Medicinal Chemistry ◽

10.1021/jm991010h ◽

1999 ◽

Vol 42 (21) ◽

pp. 4343-4350 ◽

Cited By ~ 106

Author(s):

Kim Dekermendjian ◽

Pia Kahnberg ◽

Michael-Robin Witt ◽

Olov Sterner ◽

Mogens Nielsen ◽

...

Keyword(s):

Molecular Modeling ◽

Rat Brain ◽

Structure Activity Relationships ◽

Structure Activity ◽

Modeling Analysis ◽

Benzodiazepine Site

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NovelN-(Arylalkyl)indol-3-ylglyoxylylamides Targeted as Ligands of the Benzodiazepine Receptor: Synthesis, Biological Evaluation, and Molecular Modeling Analysis of the Structure−Activity Relationships†

Journal of Medicinal Chemistry ◽

10.1021/jm010827j ◽

2001 ◽

Vol 44 (14) ◽

pp. 2286-2297 ◽

Cited By ~ 15

Author(s):

Giampaolo Primofiore ◽

Federico Da Settimo ◽

Sabrina Taliani ◽

Anna Maria Marini ◽

Ettore Novellino ◽

...

Keyword(s):

Molecular Modeling ◽

Benzodiazepine Receptor ◽

Biological Evaluation ◽

Structure Activity Relationships ◽

Structure Activity ◽

Modeling Analysis

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Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

RSC Advances ◽

10.1039/d0ra04876c ◽

2020 ◽

Vol 10 (62) ◽

pp. 38128-38141

Author(s):

Sherif S. Ebada ◽

Nariman A. Al-Jawabri ◽

Fadia S. Youssef ◽

Dina H. El-Kashef ◽

Tim-Oliver Knedel ◽

...

Keyword(s):

Molecular Modeling ◽

World Health Organization ◽

World Health ◽

Medicinal Uses ◽

Structure Activity Relationships ◽

Structure Activity ◽

The World ◽

Inhibitory Activities ◽

Novel Coronavirus ◽

Health Organization

On Wednesday 11th March, 2020, the world health organization (WHO) announced novel coronavirus (COVID-19, also called SARS-CoV-2) as a pandemic.

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Novel and Selective 5-HT2C/2BReceptor Antagonists as Potential Anxiolytic Agents: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines

Journal of Medicinal Chemistry ◽

10.1021/jm970741j ◽

1998 ◽

Vol 41 (10) ◽

pp. 1598-1612 ◽

Cited By ~ 47

Author(s):

Steven M. Bromidge ◽

Steven Dabbs ◽

David T. Davies ◽

D. Malcolm Duckworth ◽

Ian T. Forbes ◽

...

Keyword(s):

Molecular Modeling ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Substituted 1

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ChemInform Abstract: Indole Amide Derivatives: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies of a New Series of Histamine H1-Receptor Antagonists.

ChemInform ◽

10.1002/chin.199929124 ◽

2010 ◽

Vol 30 (29) ◽

pp. no-no

Author(s):

Sandra Battaglia ◽

Enrico Boldrini ◽

Federico Da Settimo ◽

Giulio Dondio ◽

Concettina La Motta ◽

...

Keyword(s):

Molecular Modeling ◽

H1 Receptor ◽

Receptor Antagonists ◽

Histamine H1 Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Modeling Studies ◽

Amide Derivatives ◽

Molecular Modeling Studies

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Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure–Activity Relationships, and Molecular Modeling Studies

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.6b00182 ◽

2016 ◽

Vol 7 (10) ◽

pp. 1418-1432 ◽

Cited By ~ 9

Author(s):

Chunyang Jin ◽

Ann M. Decker ◽

Danni L. Harris ◽

Bruce E. Blough

Keyword(s):

Molecular Modeling ◽

Structure Activity Relationships ◽

Structure Activity ◽

Modeling Studies ◽

Molecular Modeling Studies

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17β-O-Aminoalkyloximes of 5β-Androstane-3β,14β-diol with Digitalis-like Activity: Synthesis, Cardiotonic Activity, Structure−Activity Relationships, and Molecular Modeling of the Na+,K+-ATPase Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm990627w ◽

2000 ◽

Vol 43 (12) ◽

pp. 2332-2349 ◽

Cited By ~ 16

Author(s):

Alberto Cerri ◽

Nicoletta Almirante ◽

Paolo Barassi ◽

Alessandra Benicchio ◽

Giorgio Fedrizzi ◽

...

Keyword(s):

Molecular Modeling ◽

Cardiotonic Activity ◽

Structure Activity Relationships ◽

Structure Activity ◽

Activity Structure

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Structure–activity relationships of β-hydroxyphosphonate nucleoside analogues as cytosolic 5′-nucleotidase II potential inhibitors: Synthesis, in vitro evaluation and molecular modeling studies

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.02.055 ◽

2014 ◽

Vol 77 ◽

pp. 18-37 ◽

Cited By ~ 16

Author(s):

Maïa Meurillon ◽

Zsuzsanna Marton ◽

Audrey Hospital ◽

Lars Petter Jordheim ◽

Jérôme Béjaud ◽

...

Keyword(s):

Molecular Modeling ◽

Nucleoside Analogues ◽

In Vitro Evaluation ◽

Structure Activity Relationships ◽

Structure Activity ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Potential Inhibitors

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Orphanin FQ: Receptor binding and analog structure activity relationships in rat brain

Life Sciences ◽

10.1016/0024-3205(96)00261-5 ◽

1996 ◽

Vol 59 (1) ◽

pp. PL23-PL29 ◽

Cited By ~ 112

Author(s):

Colette T. Dooley ◽

Richard A. Houghten

Keyword(s):

Rat Brain ◽

Receptor Binding ◽

Orphanin Fq ◽

Structure Activity Relationships ◽

Structure Activity

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ChemInform Abstract: Novel Ligands Specific for Mitochondrial Benzodiazepine Receptors: 6- Arylpyrrolo(2,1-d) (1,5)benzothiazepine Derivatives. Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies.

ChemInform ◽

10.1002/chin.199439210 ◽

2010 ◽

Vol 25 (39) ◽

pp. no-no

Author(s):

I. FIORINI ◽

V. NACCI ◽

S. M. CIANI ◽

A. GAROFALO ◽

G. CAMPIANI ◽

...

Keyword(s):

Molecular Modeling ◽

Benzodiazepine Receptors ◽

Structure Activity Relationships ◽

Structure Activity ◽

Modeling Studies ◽

Molecular Modeling Studies

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Biological Evaluation, Chelation, and Molecular Modeling Studies of Novel Metal-Chelating Inhibitors of NF-κB-DNA Binding: Structure Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm050617x ◽

2006 ◽

Vol 49 (12) ◽

pp. 3595-3601 ◽

Cited By ~ 12

Author(s):

Rakesh K. Sharma ◽

Shilpa Chopra ◽

Som D. Sharma ◽

Vineet Pande ◽

Maria J. Ramos ◽

...

Keyword(s):

Molecular Modeling ◽

Dna Binding ◽

Biological Evaluation ◽

Structure Activity Relationships ◽

Metal Chelating ◽

Structure Activity ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Binding Structure

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