Novel and Selective 5-HT2C/2BReceptor Antagonists as Potential Anxiolytic Agents:  Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines

Steven M. Bromidge; Steven Dabbs; David T. Davies; D. Malcolm Duckworth; Ian T. Forbes; Peter Ham; Graham E. Jones; Frank D. King; Damian V. Saunders; Susannah Starr; Kevin M. Thewlis; Paul A. Wyman; Frank E. Blaney; Christopher B. Naylor; Fiona Bailey; Thomas P. Blackburn; Vicky Holland; Guy A. Kennett; Graham J. Riley; Martyn D. Wood

doi:10.1021/jm970741j

Novel and Selective 5-HT2C/2BReceptor Antagonists as Potential Anxiolytic Agents: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines

Journal of Medicinal Chemistry ◽

10.1021/jm970741j ◽

1998 ◽

Vol 41 (10) ◽

pp. 1598-1612 ◽

Cited By ~ 47

Author(s):

Steven M. Bromidge ◽

Steven Dabbs ◽

David T. Davies ◽

D. Malcolm Duckworth ◽

Ian T. Forbes ◽

...

Keyword(s):

Molecular Modeling ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Substituted 1

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Quantitative Structure-Activity Relationships of Antibacterial Agents, 7-Heterocyclic Amine Substituted 1-Cyclopropyl-6,8-difluoro-4-oxoquinoline-3-carboxylic Acids.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.41.126 ◽

1993 ◽

Vol 41 (1) ◽

pp. 126-131 ◽

Cited By ~ 22

Author(s):

Tetsuo OKADA ◽

Kiyoshi EZUMI ◽

Masumi YAMAKAWA ◽

Hisao SATO ◽

Teruji TSUJI ◽

...

Keyword(s):

Carboxylic Acids ◽

Antibacterial Agents ◽

Heterocyclic Amine ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Substituted 1

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ChemInform Abstract: Quantitative Structure-Activity Relationships of Antibacterial Agents, 7-Heterocyclic Amine Substituted 1-Cyclopropyl-6,8-difluoro-4- oxoquinoline-3-carboxylic Acids.

ChemInform ◽

10.1002/chin.199325281 ◽

2010 ◽

Vol 24 (25) ◽

pp. no-no

Author(s):

T. OKADA ◽

K. EZUMI ◽

M. YAMAKAWA ◽

H. SATO ◽

T. TSUJI ◽

...

Keyword(s):

Carboxylic Acids ◽

Antibacterial Agents ◽

Heterocyclic Amine ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Substituted 1

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Quantitative structure–activity relationships for a series of inhibitors of cruzain from Trypanosoma cruzi: Molecular modeling, CoMFA and CoMSIA studies

Journal of Molecular Graphics and Modelling ◽

10.1016/j.jmgm.2009.03.001 ◽

2009 ◽

Vol 28 (1) ◽

pp. 3-11 ◽

Cited By ~ 30

Author(s):

Gustavo H.G. Trossini ◽

Rafael V.C. Guido ◽

Glaucius Oliva ◽

Elizabeth I. Ferreira ◽

Adriano D. Andricopulo

Keyword(s):

Molecular Modeling ◽

Trypanosoma Cruzi ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Quantitative Structure-Activity Relationships of Potential Antimalarial Drugs Active Against Chloroquine-Resistant Plasmodium Falciparum

Planta Medica ◽

10.1055/s-2008-1075144 ◽

2008 ◽

Vol 74 (03) ◽

Author(s):

SJ Hocart ◽

H Liu ◽

D De ◽

FM Krogstad ◽

DJ Krogstad

Keyword(s):

Plasmodium Falciparum ◽

Antimalarial Drugs ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Parabolic Quantitative Structure–Activity Relationships and Photodynamic Therapy: Application of a Three-Compartment Model with Clearance to the In Vivo Quantitative Structure–Activity Relationships of a Congeneric Series of Pyropheophorbide Derivatives Used as Photosensitizers for Photodynamic Therapy

Photochemistry and Photobiology ◽

10.1562/0031-8655(1999)070<0781:pqsrap>2.3.co;2 ◽

1999 ◽

Vol 70 (5) ◽

pp. 781 ◽

Cited By ~ 2

Author(s):

W. R. Potter ◽

B. W. Henderson ◽

D. A. Bellnier ◽

R. K. Pandey ◽

L. A. Vaughan ◽

...

Keyword(s):

Photodynamic Therapy ◽

Compartment Model ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Three Compartment Model ◽

Quantitative Structure Activity Relationships

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Binding Affinity of Triphenyl Acrylonitriles to Estrogen Receptors: Quantitative Structure-Activity Relationships

Folia Medica ◽

10.2478/v10153-010-0005-2 ◽

2010 ◽

Vol 52 (3) ◽

Cited By ~ 1

Author(s):

Sorana Bolboacă ◽

Monica Marta ◽

Lorentz Jäntschi

Keyword(s):

Estrogen Receptors ◽

Binding Affinity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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Quantitative Structure-Activity Relationships for Cellular Uptake of Surface-Modified Nanoparticles

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207318666150306105525 ◽

2015 ◽

Vol 18 (4) ◽

pp. 365-375 ◽

Cited By ~ 6

Author(s):

Rong Liu ◽

Robert Rallo ◽

Muhammad Bilal ◽

Yoram Cohen

Keyword(s):

Cellular Uptake ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Surface Modified ◽

Surface Modified Nanoparticles

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Investigation of the Structural Requirement for Blocking the Human CCR5 Chemokine Receptor. An Insight from Quantitative Structure Activity Relationships Study

Letters in Drug Design & Discovery ◽

10.2174/157018009787582615 ◽

2009 ◽

Vol 6 (2) ◽

pp. 114-124 ◽

Cited By ~ 1

Author(s):

Nigus Dessalew

Keyword(s):

Chemokine Receptor ◽

Quantitative Structure ◽

Structural Requirement ◽

Ccr5 Chemokine Receptor ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Human Ccr5

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Quantitative structure activity relationships (QSARs) and machine learning models for abiotic reduction of organic compounds by an aqueous Fe(II) complex

Water Research ◽

10.1016/j.watres.2021.116843 ◽

2021 ◽

Vol 192 ◽

pp. 116843

Author(s):

Yidan Gao ◽

Shifa Zhong ◽

Tifany L. Torralba-Sanchez ◽

Paul G. Tratnyek ◽

Eric J. Weber ◽

...

Keyword(s):

Machine Learning ◽

Organic Compounds ◽

Quantitative Structure ◽

Learning Models ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Abiotic Reduction ◽

Machine Learning Models

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Quantitative structure-activity relationships studies of CCR5 inhibitors and toxicity of aromatic compounds using gene expression programming

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2009.09.022 ◽

2010 ◽

Vol 45 (1) ◽

pp. 49-54 ◽

Cited By ~ 8

Author(s):

Weimin Shi ◽

Xiaoya Zhang ◽

Qi Shen

Keyword(s):

Gene Expression ◽

Aromatic Compounds ◽

Gene Expression Programming ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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