Quantitative Structure−Activity Relationships among Macrolide Antibacterial Agents:  In Vitro and in Vivo Potency againstPasteurella multocida

1997 ◽  
Vol 40 (9) ◽  
pp. 1340-1346 ◽  
Author(s):  
James W. McFarland ◽  
Cynthia M. Berger ◽  
Susan A. Froshauer ◽  
Shigeru F. Hayashi ◽  
Scott J. Hecker ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Quantitative Structure ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Quantitative Structure Activity Relationships

Quantitative Structure Activity Relationships of Fungicidally Active Triazoles: Analogs and Stereoisomers of Propiconazole and Etaconazole Quantitative Structure Activity Relationships of Fungicidally Active Triazoles: Analogs and Stereoisomers of Propiconazole and Etaconazole

1989 ◽  
Vol 44 (1-2) ◽  
pp. 85-96 ◽  
Author(s):  
E. Ebert ◽  
W. Eckhardt ◽  
K. Jäkel ◽  
D. Sozzi ◽  
C. Vogel ◽  
...  
Keyword(s):  
Fungicidal Activity ◽  
Quantitative Structure ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Quantitative Structure Activity Relationships

Abstract The preparation of the four stereoisomers of propiconazole (TILT®) is described. Their inhibition of the 14α-C-demethylation of the sterol nucleus is examined and compared with the inhibition by the four stereoisomers of etaconazole (SONAX®). The quantitative structure-activity relationships (QSAR) of substituted 1,3-dioxolane-2-yl-methyltriazoles and 1,3-dioxane-2-ylmethyltriazoles on in vivo fungicidal activity are investigated.

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