scholarly journals Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents

2009 ◽  
Vol 52 (15) ◽  
pp. 4892-4902 ◽  
Author(s):  
Aleem Gangjee ◽  
Wei Li ◽  
Roy L. Kisliuk ◽  
Vivian Cody ◽  
Jim Pace ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Antitumor Agents ◽  
Design Synthesis ◽  
X Ray ◽  
Reductase Inhibitors ◽  
Dihydrofolate Reductase Inhibitors ◽  
Potential Antitumor

Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent1

2000 ◽  
Vol 43 (21) ◽  
pp. 3837-3851 ◽  
Author(s):  
Aleem Gangjee ◽  
Jianming Yu ◽  
John J. McGuire ◽  
Vivian Cody ◽  
Nikolai Galitsky ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Dual Inhibitor ◽  
Design Synthesis ◽  
X Ray

ChemInform Abstract: Synthesis, Crystal Structure and Biological Properties of a New Series of Lipophilic s-Triazines, Dihydrofolate Reductase Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 24 (30) ◽  
pp. no-no
Author(s):  
P. TSITSA ◽  
E. ANTONIADOU-VYZA ◽  
S. J. HAMODRAKAS ◽  
E. E. ELIOPOULOS ◽  
A. TSANTILI-KAKOULIDOU ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dihydrofolate Reductase ◽  
Biological Properties ◽  
Reductase Inhibitors ◽  
Dihydrofolate Reductase Inhibitors
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