Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent1

Aleem Gangjee; Jianming Yu; John J. McGuire; Vivian Cody; Nikolai Galitsky; Roy L. Kisliuk; Sherry F. Queener

doi:10.1021/jm000200l

Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent1

Journal of Medicinal Chemistry ◽

10.1021/jm000200l ◽

2000 ◽

Vol 43 (21) ◽

pp. 3837-3851 ◽

Cited By ~ 44

Author(s):

Aleem Gangjee ◽

Jianming Yu ◽

John J. McGuire ◽

Vivian Cody ◽

Nikolai Galitsky ◽

...

Keyword(s):

Crystal Structure ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Dual Inhibitor ◽

Design Synthesis ◽

X Ray

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Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents

Journal of Medicinal Chemistry ◽

10.1021/jm900490a ◽

2009 ◽

Vol 52 (15) ◽

pp. 4892-4902 ◽

Cited By ~ 38

Author(s):

Aleem Gangjee ◽

Wei Li ◽

Roy L. Kisliuk ◽

Vivian Cody ◽

Jim Pace ◽

...

Keyword(s):

Crystal Structure ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Antitumor Agents ◽

Design Synthesis ◽

X Ray ◽

Reductase Inhibitors ◽

Dihydrofolate Reductase Inhibitors ◽

Potential Antitumor

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Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.03.067 ◽

2011 ◽

Vol 19 (11) ◽

pp. 3585-3594 ◽

Cited By ~ 15

Author(s):

Xin Zhang ◽

Xilin Zhou ◽

Roy L. Kisliuk ◽

Jennifer Piraino ◽

Vivian Cody ◽

...

Keyword(s):

Crystal Structure ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Biological Evaluation ◽

Design Synthesis ◽

X Ray ◽

Reductase Inhibitors ◽

Dihydrofolate Reductase Inhibitors

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Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2019.02.008 ◽

2019 ◽

Vol 29 (8) ◽

pp. 1012-1018 ◽

Cited By ~ 5

Author(s):

Kai Cheng ◽

Shiyu Li ◽

Xiao Lv ◽

Yongbin Tian ◽

Haiyan Kong ◽

...

Keyword(s):

Crystal Structure ◽

Monoamine Oxidase ◽

Biological Evaluation ◽

Monoamine Oxidase B ◽

Design Synthesis ◽

X Ray ◽

Synthesis And Biological Evaluation

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Phenolic P2/P3 Core Motif as Thrombin Inhibitors — Design, Synthesis, and X-Ray Co-Crystal Structure.

ChemInform ◽

10.1002/chin.200619076 ◽

2006 ◽

Vol 37 (19) ◽

Author(s):

Stephen Hanessian ◽

Eric Therrien ◽

Willem A. L. van Otterlo ◽

Malken Bayrakdarian ◽

Ingemar Nilsson ◽

...

Keyword(s):

Crystal Structure ◽

Thrombin Inhibitors ◽

Design Synthesis ◽

Core Motif ◽

X Ray

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Design, synthesis and characterization of picoline based organoselenium compounds, 1,2-bis(pyridine-2/3/4-yl)methyl diselanes: X-ray crystal structure of 1,2-bis(pyridine-3-yl)methyldiselane

Journal of Organometallic Chemistry ◽

10.1016/j.jorganchem.2015.02.024 ◽

2015 ◽

Vol 785 ◽

pp. 19-25 ◽

Cited By ~ 8

Author(s):

A.K.K. Bhasin ◽

C. Jacob ◽

F. Sasse ◽

K. Karaghiosoff ◽

K.K. Bhasin ◽

...

Keyword(s):

Crystal Structure ◽

Synthesis And Characterization ◽

Organoselenium Compounds ◽

Design Synthesis ◽

X Ray

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Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.08.044 ◽

2009 ◽

Vol 17 (20) ◽

pp. 7324-7336 ◽

Cited By ~ 26

Author(s):

Aleem Gangjee ◽

Wei Li ◽

Lu Lin ◽

Yibin Zeng ◽

Michael Ihnat ◽

...

Keyword(s):

Tyrosine Kinase ◽

Crystal Structures ◽

Dihydrofolate Reductase ◽

Design Synthesis ◽

X Ray ◽

Reductase Inhibitors ◽

Dihydrofolate Reductase Inhibitors

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Metal-metal double bond formation via steric design. Synthesis and x-ray crystal structure of [Rh(.mu.-tert-Bu2P)(CO)(PMe3)]2(Rh:Rh)

Organometallics ◽

10.1021/om50006a024 ◽

1983 ◽

Vol 2 (12) ◽

pp. 1842-1845 ◽

Cited By ~ 25

Author(s):

Richard A. Jones ◽

Thomas C. Wright

Keyword(s):

Crystal Structure ◽

Double Bond ◽

Bond Formation ◽

Design Synthesis ◽

X Ray ◽

Metal Metal

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Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase–thymidylate synthase fromPlasmodium falciparum. Erratum

Acta Crystallographica Section D Biological Crystallography ◽

10.1107/s0907444904007838 ◽

2004 ◽

Vol 60 (6) ◽

pp. 1185-1185

Author(s):

Penchit Chitnumsub ◽

Jirundon Yuvaniyama ◽

Jarunee Vanichtanankul ◽

Sumalee Kamchonwongpaisan ◽

Malcolm D. Walkinshaw ◽

...

Keyword(s):

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

X Ray

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Phenolic P2/P3 core motif as thrombin inhibitors—Design, synthesis, and X-ray co-crystal structure

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.10.082 ◽

2006 ◽

Vol 16 (4) ◽

pp. 1032-1036 ◽

Cited By ~ 11

Author(s):

Stephen Hanessian ◽

Eric Therrien ◽

Willem A.L. van Otterlo ◽

Malken Bayrakdarian ◽

Ingemar Nilsson ◽

...

Keyword(s):

Crystal Structure ◽

Thrombin Inhibitors ◽

Design Synthesis ◽

Core Motif ◽

X Ray

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Discovery of Quinazoline-2,4(1H,3H)-dione Derivatives Containing 3-Substituted Piperizines as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c01522 ◽

2021 ◽

Author(s):

Jie Zhou ◽

Ming Ji ◽

Xiaoyu Wang ◽

Hailong Zhao ◽

Ran Cao ◽

...

Keyword(s):

Crystal Structure ◽

Antitumor Activity ◽

Structure Analysis ◽

Crystal Structure Analysis ◽

Design Synthesis ◽

X Ray ◽

In Vivo Antitumor Activity ◽

Parp 1

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