Design, Synthesis, and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors

Aleem Gangjee; Wei Li; Jie Yang; Roy L. Kisliuk

doi:10.1021/jm701052u

Design, Synthesis, and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm701052u ◽

2008 ◽

Vol 51 (1) ◽

pp. 68-76 ◽

Cited By ~ 30

Author(s):

Aleem Gangjee ◽

Wei Li ◽

Jie Yang ◽

Roy L. Kisliuk

Keyword(s):

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Biological Evaluation ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors

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Design, Synthesis and Biological Evaluation of 2,4-Diamino-6-methyl-5-substituted-pyrrolo[2,3-d]pyrimidines as Dihydrofolate Reductase Inhibitors.

ChemInform ◽

10.1002/chin.200541160 ◽

2005 ◽

Vol 36 (41) ◽

Author(s):

Aleem Gangjee ◽

Hiteshkumar D. Jain ◽

Sherry F. Queener

Keyword(s):

Dihydrofolate Reductase ◽

Biological Evaluation ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors

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Rational drug design, synthesis and biological evaluation of dihydrofolate reductase inhibitors as antituberculosis agents

Future Medicinal Chemistry ◽

10.4155/fmc.15.48 ◽

2015 ◽

Vol 7 (8) ◽

pp. 979-988 ◽

Cited By ~ 8

Author(s):

Nilesh R Tawari ◽

Seema Bag ◽

Archana Raju ◽

Arundhati C Lele ◽

Ranjeet Bairwa ◽

...

Keyword(s):

Drug Design ◽

Dihydrofolate Reductase ◽

Biological Evaluation ◽

Rational Drug Design ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Rational Drug ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors

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ChemInform Abstract: Selective Pneumocystis carinii Dihydrofolate Reductase Inhibitors: Design, Synthesis, and Biological Evaluation of New 2,4-Diamino-5-substituted-furo[2,3-d]pyrimidines.

ChemInform ◽

10.1002/chin.199830172 ◽

2010 ◽

Vol 29 (30) ◽

pp. no-no

Author(s):

A. GANGJEE ◽

X. GUO ◽

S. F. QUEENER ◽

V. CODY ◽

N. GALITSKY ◽

...

Keyword(s):

Dihydrofolate Reductase ◽

Pneumocystis Carinii ◽

Biological Evaluation ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors

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Design, synthesis and biological evaluation of 2,4-diamino-6-methyl-5-substitutedpyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors

Journal of Heterocyclic Chemistry ◽

10.1002/jhet.5570420418 ◽

2005 ◽

Vol 42 (4) ◽

pp. 589-594 ◽

Cited By ~ 7

Author(s):

Aleem Gangjee ◽

Hiteshkumar D. Jain ◽

Sherry F. Queener

Keyword(s):

Dihydrofolate Reductase ◽

Biological Evaluation ◽

Design Synthesis ◽

Reductase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors

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Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2018.04.032 ◽

2018 ◽

Vol 26 (9) ◽

pp. 2640-2650 ◽

Cited By ~ 4

Author(s):

Khushbu Shah ◽

Xin Lin ◽

Sherry F. Queener ◽

Vivian Cody ◽

Jim Pace ◽

...

Keyword(s):

Amino Acid ◽

Dihydrofolate Reductase ◽

Biological Evaluation ◽

Amino Acid Residues ◽

Design Synthesis ◽

Specific Amino Acid ◽

Reductase Inhibitors ◽

Species Specific ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors

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Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.03.067 ◽

2011 ◽

Vol 19 (11) ◽

pp. 3585-3594 ◽

Cited By ~ 15

Author(s):

Xin Zhang ◽

Xilin Zhou ◽

Roy L. Kisliuk ◽

Jennifer Piraino ◽

Vivian Cody ◽

...

Keyword(s):

Crystal Structure ◽

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Biological Evaluation ◽

Design Synthesis ◽

X Ray ◽

Reductase Inhibitors ◽

Dihydrofolate Reductase Inhibitors

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Synthesis and biological evaluation of a new series of dihydrofolate reductase inhibitors based on the 4-(2,6-diamino-5-pyrimidinyl)alkyl-L-glutamic acid structure

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/0960-894x(96)00053-4 ◽

1996 ◽

Vol 6 (4) ◽

pp. 473-476 ◽

Cited By ~ 9

Author(s):

Lynn S. Gossett ◽

Lillian L. Habeck ◽

Susan B. Gates ◽

Sherri L. Andis ◽

John F. Worzalla ◽

...

Keyword(s):

Glutamic Acid ◽

Dihydrofolate Reductase ◽

Biological Evaluation ◽

Reductase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors ◽

Acid Structure

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ChemInform Abstract: Synthesis and Biological Evaluation of a New Series of Dihydrofolate Reductase Inhibitors Based on the 4-(2,6-Diamino-5-pyrimidinyl)alkyl-L- glutamic Acid Structure.

ChemInform ◽

10.1002/chin.199625202 ◽

2010 ◽

Vol 27 (25) ◽

pp. no-no

Author(s):

L. S. GOSSETT ◽

L. L. HABECK ◽

S. B. GATES ◽

S. L. ANDIS ◽

J. F. WORZALLA ◽

...

Keyword(s):

Glutamic Acid ◽

Dihydrofolate Reductase ◽

Biological Evaluation ◽

Reductase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors ◽

Acid Structure

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ChemInform Abstract: Synthesis and Biological Evaluation of 5-Arylfuro[2,3-d]pyrimidines as Novel Dihydrofolate Reductase Inhibitors.

ChemInform ◽

10.1002/chin.199937162 ◽

2010 ◽

Vol 30 (37) ◽

pp. no-no

Author(s):

Farid Wahid ◽

Claude Monneret ◽

Daniel Dauzonne

Keyword(s):

Dihydrofolate Reductase ◽

Biological Evaluation ◽

Reductase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Dihydrofolate Reductase Inhibitors

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Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase as Antitumor Agents: Design, Synthesis, and Biological Evaluation of Classical and Nonclassical Pyrrolo[2,3-d]pyrimidine Antifolates1

Journal of Medicinal Chemistry ◽

10.1021/jm058276a ◽

2006 ◽

Vol 49 (3) ◽

pp. 1055-1065 ◽

Cited By ~ 30

Author(s):

Aleem Gangjee ◽

Hiteshkumar D. Jain ◽

Jaclyn Phan ◽

Xin Lin ◽

Xiaohong Song ◽

...

Keyword(s):

Dihydrofolate Reductase ◽

Thymidylate Synthase ◽

Antitumor Agents ◽

Biological Evaluation ◽

Design Synthesis ◽

Dual Inhibitors ◽

Synthesis And Biological Evaluation

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