Synthesis and Evaluation of Estrogen Agonism of Diaryl 4,5-Dihydroisoxazoles, 3-Hydroxyketones, 3-Methoxyketones, and 1,3-Diketones: A Compound Set Forming a 4D Molecular Library

2008 ◽  
Vol 51 (12) ◽  
pp. 3562-3571 ◽  
Author(s):  
Juha T. Pulkkinen ◽  
Paavo Honkakoski ◽  
Mikael Peräkylä ◽  
Istvan Berczi ◽  
Reino Laatikainen
Keyword(s):  
Molecular Library

scholarly journals 5′,8-Cyclopurine Lesions in DNA Damage: Chemical, Analytical, Biological, and Diagnostic Significance

Cells ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 513 ◽  
Author(s):  
Chryssostomos Chatgilialoglu ◽  
Carla Ferreri ◽  
Nicholas E. Geacintov ◽  
Marios G. Krokidis ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Genetic Instability ◽  
Model Systems ◽  
Diagnostic Significance ◽  
Purine Base ◽  
Repair Mechanisms ◽  
Cellular Dna ◽  
Radical Attack ◽  
Molecular Library

Purine 5′,8-cyclo-2′-deoxynucleosides (cPu) are tandem-type lesions observed among the DNA purine modifications and identified in mammalian cellular DNA in vivo. These lesions can be present in two diasteroisomeric forms, 5′R and 5′S, for each 2′-deoxyadenosine and 2′-deoxyguanosine moiety. They are generated exclusively by hydroxyl radical attack to 2′-deoxyribose units generating C5′ radicals, followed by cyclization with the C8 position of the purine base. This review describes the main recent achievements in the preparation of the cPu molecular library for analytical and DNA synthesis applications for the studies of the enzymatic recognition and repair mechanisms, their impact on transcription and genetic instability, quantitative determination of the levels of lesions in various types of cells and animal model systems, and relationships between the levels of lesions and human health, disease, and aging, as well as the defining of the detection limits and quantification protocols.

scholarly journals Novel antibody specificities targeting glycoprotein B of cytomegalovirus identified by molecular library technology

2009 ◽  
Vol 25 (6) ◽  
pp. 429-436 ◽  
Author(s):  
Fredrika Axelsson ◽  
Jonas Persson ◽  
Emmanuel Moreau ◽  
Marie-Hélène Côté ◽  
Alain Lamarre ◽  
...  
Keyword(s):  
Glycoprotein B ◽  
Antibody Specificities ◽  
Library Technology ◽  
Molecular Library

scholarly journals Matter–wave interference of particles selected from a molecular library with masses exceeding 10 000 amu

2013 ◽  
Vol 15 (35) ◽  
pp. 14696 ◽  
Author(s):  
Sandra Eibenberger ◽  
Stefan Gerlich ◽  
Markus Arndt ◽  
Marcel Mayor ◽  
Jens Tüxen
Keyword(s):  
Matter Wave ◽  
Wave Interference ◽  
Molecular Library

scholarly journals Synthesis and Preliminarily Cytotoxicity to A549, HCT116 and MCF-7 Cell Lines of Thieno[2,3-d]pyrimidine Derivatives Containing Isoxazole Moiety

2017 ◽  
Author(s):  
Jianping Yong ◽  
Canzhong Lu ◽  
Xiaoyuan Wu
Keyword(s):  
Cell Lines ◽  
Anticancer Drugs ◽  
Broad Spectrum ◽  
Pyrimidine Derivatives ◽  
Reference Drug ◽  
Drug Candidates ◽  
Mtt Method ◽  
Novel Structures ◽  
Molecular Library ◽  
Mcf 7

Under the guidance of our previous achievements, and in order to extend this small molecular library. In current work, other 21 novel structures of thieno[2,3-d]pyrimidines containing isoxazole-moiety (1a-1u) were firstly synthesized and the cytotoxicity to A549, HCT116 and MCF-7 cell lines was evaluated using the MTT method. The results showed that most target compounds exhibited good to excellent cytotoxicity to A549, HCT116 and MCF-7 cell lines, especially 6-Methyl-4-{[3-(4-chlorophenyl)-isoxazol-5-yl-]-methoxy-}-thieno[2,3-d]-pyrimidine (1e) exhibited a broad-spectrum and the most potent cytotoxicity to A549, HCT116 and MCF-7 cell lines (IC50s: 2.79, 6.69 and 4.21×10-3 μM, respectively) as compared with the reference drug gefitinib (IC50s: 17.90, 21.55 and 20.68 μM, respectively). 1e can be seen as the best drug candidates for development of anticancer drugs.

Abstract LB-129: Small molecular library screening to find methyl binding domain 2 protein inhibitors

2014 ◽  
Author(s):  
Nicolas A. Wyhs ◽  
Hugh Giovinazzo ◽  
David Walker ◽  
Srinivasan Yegnasubramanian ◽  
William G. Nelson
Keyword(s):  
Binding Domain ◽  
Library Screening ◽  
Protein Inhibitors ◽  
Molecular Library

Pericardial fluid: an underrated molecular library of heart conditions and a potential vehicle for cardiac therapy

2019 ◽  
Vol 114 (2) ◽  
Author(s):  
Fábio Trindade ◽  
Rui Vitorino ◽  
Adelino Leite-Moreira ◽  
Inês Falcão-Pires
Keyword(s):  
Pericardial Fluid ◽  
Cardiac Therapy ◽  
Molecular Library

Stepwise Construction of Heterobimetallic Cages by an Extended Molecular Library Approach

2017 ◽  
Vol 57 (7) ◽  
pp. 3507-3515 ◽  
Author(s):  
Matthias Hardy ◽  
Niklas Struch ◽  
Filip Topić ◽  
Gregor Schnakenburg ◽  
Kari Rissanen ◽  
...  
Keyword(s):  
Molecular Library

Solid phase synthesis of a molecular library of pyrimidines, pyrazoles, and isoxazoles with biological potential

2010 ◽  
Vol 51 (13) ◽  
pp. 1702-1705 ◽  
Author(s):  
Giovanni Pellegrino ◽  
Francesco Leonetti ◽  
Angelo Carotti ◽  
Orazio Nicolotti ◽  
Leonardo Pisani ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Biological Potential ◽  
Molecular Library
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