scholarly journals An inquiry-based exercise in medicinal chemistry: Synthesis of a molecular library and screening for potential antimalarial and anti-inflammatory compounds

2018 ◽  
Vol 46 (5) ◽  
pp. 424-434 ◽  
Author(s):  
David J. Hall ◽  
Charles G. Martin ◽  
Michael Welford ◽  
Stefan L. Debbert
Keyword(s):  
Medicinal Chemistry ◽  
Anti Inflammatory ◽  
Molecular Library

Recent update on the anti-infective potential of β-carboline analogs

2020 ◽  
Vol 20 ◽  
Author(s):  
Faheem ◽  
Banoth Karan Kumar ◽  
Kondapalli Venkata Gowri Chandra Sekhar ◽  
Selvaraj Kunjiappan ◽  
Joazaizulfazli Jamalis ◽  
...  
Keyword(s):  
Pharmacological Activity ◽  
Mechanism Of Action ◽  
Medicinal Chemistry ◽  
Indole Alkaloid ◽  
Naturally Occurring ◽  
Anti Inflammatory ◽  
Infective Potential ◽  
Natural And Synthetic

: β-Carboline, a naturally occurring indole alkaloid, holds a momentous spot in the field of medicinal chemistry due to its myriad of pharmacological actions like anticancer, antiviral, antibacterial, antifungal, antileishmanial, antimalarial, neuropharmacological, anti-inflammatory, anti-thrombotic among others. β-Carbolines exhibit their pharmacological activity via diverse mechanisms. This review provides a recent update (2015-2020) on the anti-infective potential of natural and synthetic β-carboline analogs with particular focus on its antibacterial, antifungal, antiviral, antimalarial, antileishmanial and antitrypanosomal properties. In cases where enough details are available, a note on its mechanism of action is also added.

Benzimidazole: A Milestone in the Field of Medicinal Chemistry

2020 ◽  
Vol 20 (7) ◽  
pp. 532-565 ◽  
Author(s):  
Mahesh S. Vasava ◽  
Manoj N. Bhoi ◽  
Sanjay K. Rathwa ◽  
Divya J. Jethava ◽  
Prachi T. Acharya ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Benzimidazole Derivatives ◽  
Drug Candidate ◽  
Pharmacological Activities ◽  
Drug Candidates ◽  
The Future ◽  
Anti Inflammatory ◽  
Anti Fungal ◽  
Derivatives Of ◽  
Anti Hiv

In the last 2-3 decades, the broad research in the application of benzimidazole derivatives made it important for mankind. Many scientists have worked on benzimidazole derivatives and they found that this compound has a diverse role in the field of medicinal chemistry. Few benzimidazole derivatives are currently in the market as a drug candidate against various diseases. Moreover, the benzimidazole derivatives exhibit pharmacological activities such as anti-tuberculosis, anti-malarial, antihistamine, antimicrobial, antiviral, antidiabetic, anticancer, anti-fungal, anti-inflammatory, analgesic, anti-HIV, etc. In this review, we have summarized various derivatives of benzimidazole which have been prepared by many researchers to understand the chemistry as well as diverse pharmacological activities. These findings may lead the scientists who are working in the field of medicinal chemistry to the development of benzimidazole based drug candidates in the future.

A Mini Review on Recent Advancements in the Therapeutic Potentials of Benzothiazoles

2019 ◽  
Vol 16 ◽  
Author(s):  
Rubina Bhutani ◽  
Garima Kapoor ◽  
Dharam Pal Pathak ◽  
Asif Husain ◽  
Ravi Kant ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Therapeutic Potential ◽  
Pharmaceutical Chemistry ◽  
Biological Potential ◽  
Heterocyclic Derivatives ◽  
Anti Inflammatory ◽  
Clinical Drugs

: Among the various fused heterocyclic rings, benzothiazole and its analogues have been explored broadly in search of newer therapeutic medicinal agents. The benzothiazole scaffold has been associated with huge biological potential like anticancer, antidiabetic, anti-inflammatory, anti-tubercular, antiviral, anti-convulsant etc. The occurrence of benzothiazole core in various compounds proves its value in the sphere of pharmaceutical chemistry. The connected research and developments in benzothiazole based chemistry become an active topic for medicinal scientists. A large number of benzothiazole and its heterocyclic derivatives are available in the market and used for the treatment of as clinical drugs have been extensively used in practice to treat diverse types of ailments with high therapeutic potential. This review presents the latest therapeutic developments of benzothiazole containing compounds in the medicinal chemistry.

Recent advancements on Benzimidazole: A versatile scaffold in medicinal chemistry

2021 ◽  
Vol 21 ◽  
Author(s):  
Zohor Mohammad Mahdi Alzhrani ◽  
Mohammad Mahboob Alam ◽  
Syed Nazreen
Keyword(s):  
Clinical Trials ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Review Article ◽  
Present Review ◽  
Benzimidazole Derivatives ◽  
The Past ◽  
Anti Inflammatory

: Benzimidazole is nitrogen containing fused heterocycle which has been extensively explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various biological activities such as anticancer, antimicrobial, anti-inflammatory, antiviral, antitubercular and antidiabetic. A number of benzimidazoles such as bendamustine, pantoprazole have been approved for the treatment of various illnesses whereas galeterone and GSK461364 are in clinical trials. The present review article gives an overview about the different biological activities exhibited by the benzimidazole derivatives as well as different methods used for the synthesis of benzimidazole derivatives for the past ten years.

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