Design, Synthesis, and Biological Evaluation of Novel Tri- and Tetrasubstituted Imidazoles as Highly Potent and Specific ATP-Mimetic Inhibitors of p38 MAP Kinase: Focus on Optimized Interactions with the Enzyme’s Surface-Exposed Front Region

2008 ◽  
Vol 51 (14) ◽  
pp. 4122-4149 ◽  
Author(s):  
Stefan A. Laufer ◽  
Dominik R. J. Hauser ◽  
David M. Domeyer ◽  
Katrin Kinkel ◽  
Andy J. Liedtke
Keyword(s):  
Map Kinase ◽  
Biological Evaluation ◽  
P38 Map Kinase ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Tetrasubstituted Imidazoles ◽  
Front Region

scholarly journals Design, Synthesis, and Biological Evaluation of Chromone-Based p38 MAP Kinase Inhibitors

2011 ◽  
Vol 54 (20) ◽  
pp. 7427-7431 ◽  
Author(s):  
Christine Dyrager ◽  
Linda Nilsson Möllers ◽  
Linda Karlsson Kjäll ◽  
John Patrick Alao ◽  
Peter Dinér ◽  
...  
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
P38 Map Kinase ◽  
Design Synthesis ◽  
P38 Map Kinase Inhibitors ◽  
Synthesis And Biological Evaluation

Structure‐Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5‐ b ]Pyridin‐2‐one‐Based p38 MAP Kinase Inhibitors: Part 2

ChemMedChem ◽  
2019 ◽  
Vol 14 (24) ◽  
pp. 2093-2101
Author(s):  
Akira Kaieda ◽  
Masashi Takahashi ◽  
Hiromi Fukuda ◽  
Rei Okamoto ◽  
Shinji Morimoto ◽  
...  
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
P38 Map Kinase ◽  
Design Synthesis ◽  
P38 Map Kinase Inhibitors ◽  
Synthesis And Biological Evaluation

Structure‐Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5‐ b ]pyridin‐2‐one‐Based p38 MAP Kinase Inhibitors: Part 1

ChemMedChem ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. 1022-1030 ◽  
Author(s):  
Akira Kaieda ◽  
Masashi Takahashi ◽  
Hiromi Fukuda ◽  
Rei Okamoto ◽  
Shinji Morimoto ◽  
...  
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
P38 Map Kinase ◽  
Design Synthesis ◽  
P38 Map Kinase Inhibitors ◽  
Synthesis And Biological Evaluation

Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors

2018 ◽  
Vol 26 (3) ◽  
pp. 647-660 ◽  
Author(s):  
Akira Kaieda ◽  
Masashi Takahashi ◽  
Takafumi Takai ◽  
Masayuki Goto ◽  
Takahiro Miyazaki ◽  
...  
Keyword(s):  
Map Kinase ◽  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
P38 Map Kinase ◽  
Design Synthesis ◽  
P38 Map Kinase Inhibitors ◽  
Synthesis And Biological Evaluation

Structure-based design, synthesis and biological evaluation of N-pyrazole, N′-thiazole urea inhibitors of MAP kinase p38α

2012 ◽  
Vol 48 ◽  
pp. 1-15 ◽  
Author(s):  
Matthäus Getlik ◽  
Christian Grütter ◽  
Jeffrey R. Simard ◽  
Hoang D. Nguyen ◽  
Armin Robubi ◽  
...  
Keyword(s):  
Map Kinase ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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