Structure‐Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5‐
            b
            ]pyridin‐2‐one‐Based p38 MAP Kinase Inhibitors: Part 1

Akira Kaieda; Masashi Takahashi; Hiromi Fukuda; Rei Okamoto; Shinji Morimoto; Masayuki Gotoh; Takahiro Miyazaki; Yuri Hori; Satoko Unno; Tomohiro Kawamoto; Toshimasa Tanaka; Sachiko Itono; Terufumi Takagi; Hiroshi Sugimoto; Kengo Okada; Gyorgy Snell; Ryan Bertsch; Jasmine Nguyen; Bi‐Ching Sang; Seiji Miwatashi

doi:10.1002/cmdc.201900129

Structure‐Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5‐ b ]pyridin‐2‐one‐Based p38 MAP Kinase Inhibitors: Part 1

ChemMedChem ◽

10.1002/cmdc.201900129 ◽

2019 ◽

Vol 14 (10) ◽

pp. 1022-1030 ◽

Cited By ~ 2

Author(s):

Akira Kaieda ◽

Masashi Takahashi ◽

Hiromi Fukuda ◽

Rei Okamoto ◽

Shinji Morimoto ◽

...

Keyword(s):

Map Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

P38 Map Kinase ◽

Design Synthesis ◽

P38 Map Kinase Inhibitors ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Chromone-Based p38 MAP Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm200818j ◽

2011 ◽

Vol 54 (20) ◽

pp. 7427-7431 ◽

Cited By ~ 28

Author(s):

Christine Dyrager ◽

Linda Nilsson Möllers ◽

Linda Karlsson Kjäll ◽

John Patrick Alao ◽

Peter Dinér ◽

...

Keyword(s):

Map Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

P38 Map Kinase ◽

Design Synthesis ◽

P38 Map Kinase Inhibitors ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Phenylamino-Substituted 6,11-Dihydro-dibenzo[b,e]oxepin-11-ones and Dibenzo[a,d]cycloheptan-5-ones: Novel p38 MAP Kinase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm061072p ◽

2006 ◽

Vol 49 (26) ◽

pp. 7912-7915 ◽

Cited By ~ 32

Author(s):

Stefan A. Laufer ◽

Gabriele M. Ahrens ◽

Solveigh C. Karcher ◽

Jörg S. Hering ◽

Raimund Niess

Keyword(s):

Map Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

P38 Map Kinase ◽

Design Synthesis ◽

P38 Map Kinase Inhibitors ◽

Synthesis And Biological Evaluation

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Structure‐Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5‐ b ]Pyridin‐2‐one‐Based p38 MAP Kinase Inhibitors: Part 2

ChemMedChem ◽

10.1002/cmdc.201900373 ◽

2019 ◽

Vol 14 (24) ◽

pp. 2093-2101

Author(s):

Akira Kaieda ◽

Masashi Takahashi ◽

Hiromi Fukuda ◽

Rei Okamoto ◽

Shinji Morimoto ◽

...

Keyword(s):

Map Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

P38 Map Kinase ◽

Design Synthesis ◽

P38 Map Kinase Inhibitors ◽

Synthesis And Biological Evaluation

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Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2017.12.031 ◽

2018 ◽

Vol 26 (3) ◽

pp. 647-660 ◽

Cited By ~ 3

Author(s):

Akira Kaieda ◽

Masashi Takahashi ◽

Takafumi Takai ◽

Masayuki Goto ◽

Takahiro Miyazaki ◽

...

Keyword(s):

Map Kinase ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

P38 Map Kinase ◽

Design Synthesis ◽

P38 Map Kinase Inhibitors ◽

Synthesis And Biological Evaluation

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Design, synthesis and SAR of phenylamino-substituted 5,11-dihydro-dibenzo[a,d]cyclohepten-10-ones and 11H-dibenzo[b,f]oxepin-10-ones as p38 MAP kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.03.107 ◽

2010 ◽

Vol 20 (10) ◽

pp. 3074-3077 ◽

Cited By ~ 17

Author(s):

Angelika Dorn ◽

Verena Schattel ◽

Stefan Laufer

Keyword(s):

Map Kinase ◽

Kinase Inhibitors ◽

P38 Map Kinase ◽

Design Synthesis ◽

P38 Map Kinase Inhibitors

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Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00745 ◽

2017 ◽

Vol 60 (19) ◽

pp. 8027-8054 ◽

Cited By ~ 11

Author(s):

Niklas M. Walter ◽

Heike K. Wentsch ◽

Mike Bührmann ◽

Silke M. Bauer ◽

Eva Döring ◽

...

Keyword(s):

Map Kinase ◽

Residence Time ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

High Potency ◽

Design Synthesis ◽

P38α Map Kinase ◽

Synthesis And Biological Evaluation ◽

Excellent Selectivity

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Faculty Opinions recommendation of Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.729083001.793536164 ◽

2017 ◽

Author(s):

John Lowe

Keyword(s):

Map Kinase ◽

Residence Time ◽

Kinase Inhibitors ◽

Biological Evaluation ◽

High Potency ◽

Design Synthesis ◽

P38α Map Kinase ◽

Synthesis And Biological Evaluation ◽

Excellent Selectivity

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Design, Synthesis, and Biological Evaluation of Novel Tri- and Tetrasubstituted Imidazoles as Highly Potent and Specific ATP-Mimetic Inhibitors of p38 MAP Kinase: Focus on Optimized Interactions with the Enzyme’s Surface-Exposed Front Region

Journal of Medicinal Chemistry ◽

10.1021/jm701529q ◽

2008 ◽

Vol 51 (14) ◽

pp. 4122-4149 ◽

Cited By ~ 55

Author(s):

Stefan A. Laufer ◽

Dominik R. J. Hauser ◽

David M. Domeyer ◽

Katrin Kinkel ◽

Andy J. Liedtke

Keyword(s):

Map Kinase ◽

Biological Evaluation ◽

P38 Map Kinase ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Tetrasubstituted Imidazoles ◽

Front Region

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ChemInform Abstract: Design, Synthesis and SAR of Phenylamino-Substituted 5,11-Dihydrodibenzo[a,d]cyclohepten-10-ones and 11H-Dibenzo[b,f]oxepin-10-ones as p38 MAP Kinase Inhibitors.

ChemInform ◽

10.1002/chin.201042171 ◽

2010 ◽

Vol 41 (42) ◽

Author(s):

Angelika Dorn ◽

Verena Schattel ◽

Stefan Laufer

Keyword(s):

Map Kinase ◽

Kinase Inhibitors ◽

P38 Map Kinase ◽

Design Synthesis ◽

P38 Map Kinase Inhibitors

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2-Acylaminopyridin-4-ylimidazoles as p38 MAP Kinase Inhibitors: Design, Synthesis, and Biological and Metabolic Evaluations

ChemMedChem ◽

10.1002/cmdc.200900242 ◽

2009 ◽

Vol 4 (11) ◽

pp. 1939-1948 ◽

Cited By ~ 21

Author(s):

Katharina Ziegler ◽

Dominik R. J. Hauser ◽

Anke Unger ◽

Wolfgang Albrecht ◽

Stefan A. Laufer

Keyword(s):

Map Kinase ◽

Kinase Inhibitors ◽

P38 Map Kinase ◽

Design Synthesis ◽

P38 Map Kinase Inhibitors

Download Full-text