Extending the Structure–Activity Relationship of Anthranilic Acid Derivatives As Farnesoid X Receptor Modulators: Development of a Highly Potent Partial Farnesoid X Receptor Agonist

Daniel Merk; Christina Lamers; Khalil Ahmad; Roberto Carrasco Gomez; Gisbert Schneider; Dieter Steinhilber; Manfred Schubert-Zsilavecz

doi:10.1021/jm500937v

Extending the Structure–Activity Relationship of Anthranilic Acid Derivatives As Farnesoid X Receptor Modulators: Development of a Highly Potent Partial Farnesoid X Receptor Agonist

Journal of Medicinal Chemistry ◽

10.1021/jm500937v ◽

2014 ◽

Vol 57 (19) ◽

pp. 8035-8055 ◽

Cited By ~ 33

Author(s):

Daniel Merk ◽

Christina Lamers ◽

Khalil Ahmad ◽

Roberto Carrasco Gomez ◽

Gisbert Schneider ◽

...

Keyword(s):

Anthranilic Acid ◽

Receptor Agonist ◽

Structure Activity Relationship ◽

Farnesoid X Receptor ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of ◽

Receptor Modulators ◽

Anthranilic Acid Derivatives

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Structure–activity relationship of bile alcohols as human farnesoid X receptor agonist

Steroids ◽

10.1016/j.steroids.2009.11.002 ◽

2010 ◽

Vol 75 (1) ◽

pp. 95-100 ◽

Cited By ~ 16

Author(s):

Yusuke Iguchi ◽

Kenji Kihira ◽

Tomoko Nishimaki-Mogami ◽

Mizuho Une

Keyword(s):

Receptor Agonist ◽

Structure Activity Relationship ◽

Farnesoid X Receptor ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

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Synthesis and Structure−Activity Relationship of Novel 6-Aryl-1,4- dihydrobenzo[d][1,3]oxazine-2-thiones as Progesterone Receptor Modulators Leading to the Potent and Selective Nonsteroidal Progesterone Receptor Agonist Tanaproget#

Journal of Medicinal Chemistry ◽

10.1021/jm050358b ◽

2005 ◽

Vol 48 (16) ◽

pp. 5092-5095 ◽

Cited By ~ 64

Author(s):

Andrew Fensome ◽

Reinhold Bender ◽

Rajiv Chopra ◽

Jeff Cohen ◽

Mark A. Collins ◽

...

Keyword(s):

Progesterone Receptor ◽

Receptor Agonist ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of ◽

Receptor Modulators ◽

Progesterone Receptor Modulators

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The Structure–Activity Relationship of a Tetrahydroisoquinoline Class ofN-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-ContainingN-Methyl-d-Aspartate Receptors

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00239 ◽

2017 ◽

Vol 60 (13) ◽

pp. 5556-5585 ◽

Cited By ~ 10

Author(s):

Katie L. Strong ◽

Matthew P. Epplin ◽

John Bacsa ◽

Christopher J. Butch ◽

Pieter B. Burger ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Aspartate Receptor ◽

Structure Activity ◽

Relationship Of ◽

Receptor Modulators

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The synthesis and structure–activity relationship of substituted N-phenyl anthranilic acid analogs as amyloid aggregation inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.12.049 ◽

2009 ◽

Vol 19 (3) ◽

pp. 654-657 ◽

Cited By ~ 31

Author(s):

Lloyd J. Simons ◽

Bradley W. Caprathe ◽

Michael Callahan ◽

James M. Graham ◽

Takenori Kimura ◽

...

Keyword(s):

Anthranilic Acid ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Amyloid Aggregation ◽

Structure Activity ◽

Aggregation Inhibitors ◽

Relationship Of

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Selective Estrogen Receptor Modulators with Conformationally Restricted Side Chains. Synthesis and Structure−Activity Relationship of ERα-Selective Tetrahydroisoquinoline Ligands

Journal of Medicinal Chemistry ◽

10.1021/jm040858p ◽

2005 ◽

Vol 48 (2) ◽

pp. 364-379 ◽

Cited By ~ 43

Author(s):

Johanne Renaud ◽

Serge François Bischoff ◽

Thomas Buhl ◽

Philipp Floersheim ◽

Brigitte Fournier ◽

...

Keyword(s):

Estrogen Receptor ◽

Selective Estrogen Receptor Modulators ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Side Chains ◽

Conformationally Restricted ◽

Estrogen Receptor Modulators ◽

Structure Activity ◽

Relationship Of ◽

Receptor Modulators

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Structure–activity relationship of nonsecosteroidal vitamin D receptor modulators

Trends in Pharmacological Sciences ◽

10.1016/j.tips.2014.04.008 ◽

2014 ◽

Vol 35 (7) ◽

pp. 324-337 ◽

Cited By ~ 28

Author(s):

Sachiko Yamada ◽

Makoto Makishima

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of ◽

Receptor Modulators

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Structure–Activity Relationship of a Broad-Spectrum Insect Odorant Receptor Agonist

ACS Chemical Biology ◽

10.1021/cb300331z ◽

2012 ◽

Vol 7 (10) ◽

pp. 1647-1652 ◽

Cited By ~ 38

Author(s):

Robert W. Taylor ◽

Ian M. Romaine ◽

Chao Liu ◽

Poornima Murthi ◽

Patrick L. Jones ◽

...

Keyword(s):

Broad Spectrum ◽

Receptor Agonist ◽

Odorant Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

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C19-Steroids as androgen receptor modulators: Design, discovery, and structure-activity relationship of new steroidal androgen receptor antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2006.05.022 ◽

2006 ◽

Vol 14 (17) ◽

pp. 5933-5947 ◽

Cited By ~ 18

Author(s):

Padma Marwah ◽

Ashok Marwah ◽

Henry A. Lardy ◽

Hiroshi Miyamoto ◽

Chawnshang Chang

Keyword(s):

Androgen Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Receptor Antagonists ◽

Structure Activity ◽

Relationship Of ◽

Receptor Modulators ◽

Androgen Receptor Antagonists

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Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure−Activity Relationship of a Series of Body and Side Chain Modified Analogues of Chenodeoxycholic Acid

Journal of Medicinal Chemistry ◽

10.1021/jm049904b ◽

2004 ◽

Vol 47 (18) ◽

pp. 4559-4569 ◽

Cited By ~ 109

Author(s):

Roberto Pellicciari ◽

Gabriele Costantino ◽

Emidio Camaioni ◽

Bahman M. Sadeghpour ◽

Antonio Entrena ◽

...

Keyword(s):

Bile Acid ◽

Chenodeoxycholic Acid ◽

Structure Activity Relationship ◽

Farnesoid X Receptor ◽

Activity Relationship ◽

Side Chain ◽

Structure Activity ◽

Bile Acid Derivatives ◽

Relationship Of

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Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2019.04.029 ◽

2019 ◽

Vol 27 (11) ◽

pp. 2220-2227 ◽

Cited By ~ 2

Author(s):

Naoki Teno ◽

Yukiko Yamashita ◽

Arisa Masuda ◽

Yusuke Iguchi ◽

Keisuke Oda ◽

...

Keyword(s):

Structure Activity Relationship ◽

Farnesoid X Receptor ◽

Activity Relationship ◽

Comprehensive Understanding ◽

Structure Activity ◽

Relationship Of

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