Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure−Activity Relationship of a Series of Body and Side Chain Modified Analogues of Chenodeoxycholic Acid

2004 ◽  
Vol 47 (18) ◽  
pp. 4559-4569 ◽  
Author(s):  
Roberto Pellicciari ◽  
Gabriele Costantino ◽  
Emidio Camaioni ◽  
Bahman M. Sadeghpour ◽  
Antonio Entrena ◽  
...  
Keyword(s):  
Bile Acid ◽  
Chenodeoxycholic Acid ◽  
Structure Activity Relationship ◽  
Farnesoid X Receptor ◽  
Activity Relationship ◽  
Side Chain ◽  
Structure Activity ◽  
Bile Acid Derivatives ◽  
Relationship Of

Structure–activity relationship of new NLO organic materials based on push–pull azodyes: 4. Side chain polymers

Polymer ◽  
2000 ◽  
Vol 41 (2) ◽  
pp. 415-421 ◽  
Author(s):  
N Tirelli ◽  
A Altomare ◽  
R Solaro ◽  
F Ciardelli ◽  
S Follonier ◽  
...  
Keyword(s):  
Organic Materials ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Side Chain ◽  
Structure Activity ◽  
Relationship Of

Structure–activity relationship of bile alcohols as human farnesoid X receptor agonist

Steroids ◽  
2010 ◽  
Vol 75 (1) ◽  
pp. 95-100 ◽  
Author(s):  
Yusuke Iguchi ◽  
Kenji Kihira ◽  
Tomoko Nishimaki-Mogami ◽  
Mizuho Une
Keyword(s):  
Receptor Agonist ◽  
Structure Activity Relationship ◽  
Farnesoid X Receptor ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

scholarly journals Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation

2003 ◽  
Vol 45 (1) ◽  
pp. 132-138 ◽  
Author(s):  
Tomofumi Fujino ◽  
Mizuho Une ◽  
Tsuneo Imanaka ◽  
Kazuhide Inoue ◽  
Tomoko Nishimaki-Mogami
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

scholarly journals Structure-activity Relationship of Pamamycins: Effect of Side Chain Length on Aerial Mycelium-inducing Activity

2008 ◽  
Vol 61 (2) ◽  
pp. 98-102 ◽  
Author(s):  
Ikuko Kozone ◽  
Makoto Hashimoto ◽  
Udo Gräfe ◽  
Hiroshi Kawaide ◽  
Hiroshi Abe ◽  
...  
Keyword(s):  
Chain Length ◽  
Aerial Mycelium ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Side Chain ◽  
Side Chain Length ◽  
Structure Activity ◽  
Relationship Of

Structure-Activity Relationship Study of Host-Specific Phytotoxins (AM-Toxin Analogs) Using a New Assay Method with Leaves from Apple Meristem Culture

2001 ◽  
Vol 56 (11-12) ◽  
pp. 1029-1037 ◽  
Author(s):  
Masahiro Miyashita ◽  
Tomoko Nakamori ◽  
Takahiro Murai ◽  
Tetsuro Yonemoto ◽  
Hisashi Miyagawa ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Ring Structure ◽  
Activity Relationship ◽  
Assay Method ◽  
Side Chain ◽  
Meristem Culture ◽  
Putative Receptor ◽  
Structure Activity ◽  
Stereoelectronic Properties ◽  
Relationship Of

Abstract AM -toxins are host-specific phytotoxins of the Alternaria alternata apple pathotype, which induce necrosis on apple leaves. In this study, we developed a new assay to measure the necrotic activity of AM -toxin analogs using cultured leaves from meristem cells. This method was not only more sensitive to AM -toxin I, but also more reliable than the previous one that used tree leaves due to the homogeneous nature of cultured leaves and to the method of application of toxins. U sing this assay method we investigated a structure-activity relationship of AM -toxin analogs synthesized in this study. Most residues and the macrocyclic ring structure were strictly recognized by AM -toxin putative receptor, whereas the L-Ala binding subsite of the receptor allowed for side chain structures with various stereoelectronic properties. These findings are important for designing ligands for further experimental probing of the nature of the receptor.

Sign in / Sign up

Export Citation Format

Share Document