Stereoselective Pharmacodynamic and Pharmacokinetic Analysis ofsec-Butylpropylacetamide (SPD), a New CNS-Active Derivative of Valproic Acid with Unique Activity against Status Epilepticus

2013 ◽  
Vol 56 (16) ◽  
pp. 6467-6477 ◽  
Author(s):  
Naama Hen ◽  
Tawfeeq Shekh-Ahmad ◽  
Boris Yagen ◽  
John H. McDonough ◽  
Richard H. Finnell ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Status Epilepticus ◽  
Pharmacokinetic Analysis ◽  
Active Derivative

scholarly journals Stereoselective anticonvulsant and pharmacokinetic analysis of valnoctamide, a CNS-active derivative of valproic acid with low teratogenic potential

Epilepsia ◽  
2013 ◽  
Vol 55 (2) ◽  
pp. 353-361 ◽  
Author(s):  
Tawfeeq Shekh-Ahmad ◽  
Naama Hen ◽  
Boris Yagen ◽  
John H. McDonough ◽  
Richard H. Finnell ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Pharmacokinetic Analysis ◽  
Active Derivative ◽  
Teratogenic Potential

scholarly journals Valproic Acid Administration in Management of Status Epilepticus Causing Reye’s Syndrome

2021 ◽  
Vol 07 (01) ◽  
pp. 044-046
Author(s):  
Pooja Prabhakar Kamath
Keyword(s):  
Valproic Acid ◽  
Status Epilepticus ◽  
Hepatic Dysfunction ◽  
Rare Condition ◽  
Normal Serum ◽  
Reye's Syndrome ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Viral Illness ◽  
Laboratory Investigations ◽  
Serum Ammonia

Abstract Introduction Valproic acid is commonly used to treat seizures in children. Regular use of valproic acid is known to cause hepatic dysfunction, and in extremely rare cases, it is known to have caused Reye’s syndrome. There are very few reports of Reye’s syndrome caused by valproic acid use. Methods A 2-year asymptomatic girl underwent modified Blalock–Taussig shunt surgery for correction of tetralogy of Fallot. Postoperatively the girl developed status epilepticus, which did not subside with initial use of intravenous midazolam and phenytoin sodium. She eventually responded to two doses of intravenous valproic acid administered 10 minutes apart. She developed depressed sensorium and was put on mechanical ventilation. The following day’s laboratory investigations revealed raised levels of serum ammonia, serum glutamic-oxaloacetic transaminase (SGOT), and serum glutamic-pyruvic transaminase (SGPT) with normal serum bilirubin. Thus, a diagnosis of Reye’s syndrome was established. The patient succumbed to disease 2 days later. Discussion Reye’s syndrome is a rare and a fulminant illness seen typically in children following a viral illness and/or use of salicylates or other medications. There are rare reports of Reye’s syndrome following use of medications like valproic acid. This patient had a noninflammatory encephalopathy with hepatic dysfunction following two doses of valproic acid. Conclusion There are very few reports on Reye’s syndrome in the literature as it is a rare condition and diagnosis is difficult. Knowledge of the presentation of Reye’s syndrome is essential for treatment and management. When using drugs like valproic acid in children, liver enzymes and serum ammonia levels should be monitored.

Pharmacokinetic analysis and anticonvulsant activity of two polyesteric prodrugs of valproic acid

1993 ◽  
Vol 14 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Salim Hadad ◽  
Tom B. Vree ◽  
Eppo Van Der Kleijn ◽  
Meir Bialer
Keyword(s):  
Valproic Acid ◽  
Anticonvulsant Activity ◽  
Pharmacokinetic Analysis

Pharmacokinetic analysis of valdice — a diethylcarbonate prodrug of valproic acid

1994 ◽  
Vol 2 (3) ◽  
pp. 239-244 ◽  
Author(s):  
Meir Bialer ◽  
Zharura Pharaj ◽  
Shulamit Zuckerman ◽  
Itamar Raz ◽  
Oded Abramsky ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Pharmacokinetic Analysis

Status Epilepticus Associated with the Combination of Valproic Acid and Clomipramine

1997 ◽  
Vol 19 (1) ◽  
pp. 71-73 ◽  
Author(s):  
J. C. DeToledo ◽  
H. Haddad ◽  
R. E. Ramsay
Keyword(s):  
Valproic Acid ◽  
Status Epilepticus

Use of Injectable Valproic Acid in Status Epilepticus

1993 ◽  
Vol 5 (3) ◽  
pp. 154-159 ◽  
Author(s):  
M. Giroud ◽  
D. Gras ◽  
A. Escousse ◽  
R. Dumas ◽  
G. Venaud
Keyword(s):  
Valproic Acid ◽  
Status Epilepticus

Valproic acid treatment of experimental status epilepticus

1992 ◽  
Vol 12 (3) ◽  
pp. 199-205 ◽  
Author(s):  
Nancy Y. Walton ◽  
David M. Treiman
Keyword(s):  
Valproic Acid ◽  
Status Epilepticus ◽  
Acid Treatment ◽  
Experimental Status
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