scholarly journals Early Exposure of Fosphenytoin, Levetiracetam and Valproic acid after High Dose Intravenous Administration in Young Children with Benzodiazepine‐refractory Status Epilepticus

2020 ◽  
Author(s):  
Abhishek G. Sathe ◽  
Usha Mishra ◽  
Vijay Ivaturi ◽  
Richard Brundage ◽  
James C. Cloyd ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Status Epilepticus ◽  
Young Children ◽  
Intravenous Administration ◽  
Refractory Status Epilepticus ◽  
High Dose ◽  
Early Exposure ◽  
Refractory Status

Very-High-Dose Phenobarbital for Childhood Refractory Status Epilepticus

2006 ◽  
Vol 34 (1) ◽  
pp. 63-65 ◽  
Author(s):  
Wai Kin Lee ◽  
Kam Tim Liu ◽  
Betty Wan Yin Young
Keyword(s):  
Status Epilepticus ◽  
Refractory Status Epilepticus ◽  
High Dose ◽  
Refractory Status ◽  
Very High

High-dose midazolam therapy for refractory status epilepticus in children

2006 ◽  
Vol 32 (12) ◽  
pp. 2070-2076 ◽  
Author(s):  
Gavin Morrison ◽  
Elizabeth Gibbons ◽  
William Patrick Whitehouse
Keyword(s):  
Status Epilepticus ◽  
Refractory Status Epilepticus ◽  
High Dose ◽  
Refractory Status

Temporal lobectomy for refractory status epilepticus in a case of limbic encephalitis

2008 ◽  
Vol 109 (4) ◽  
pp. 742-745 ◽  
Author(s):  
Tracy Weimer ◽  
Warren Boling ◽  
David Pryputniewicz ◽  
Adriana Palade
Keyword(s):  
Status Epilepticus ◽  
Limbic Encephalitis ◽  
Seizure Activity ◽  
Refractory Status Epilepticus ◽  
Temporal Lobectomy ◽  
Bronchial Biopsy ◽  
High Dose ◽  
Refractory Status ◽  
The Right ◽  
The Brain

The authors report a case of status epilepticus secondary to limbic encephalitis that was successfully treated with temporal lobectomy. A 45-year-old woman presented in status epilepticus refractory to high-dose suppressive medical therapy. Magnetic resonance imaging of the brain showed T2- and FLAIR-weighted hyperintensities in the right temporal lobe, left and right frontal lobes, and pons. A lumbar puncture revealed normal findings. Continuous electroencephalography monitoring showed continued right temporal seizure activity. A paraneoplastic panel was positive for N-type voltage-gated calcium channels. Subsequent bronchial biopsy revealed small cell carcinoma of the lung. A right temporal lobectomy was performed due to refractory status, resulting in resolution of seizure activity and recovery of good neurological function. The authors describe their case and review the literature on surgical therapy for refractory status epilepticus and limbic encephalitis.

scholarly journals Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Christopher R. Newey ◽  
Naresh Mullaguri ◽  
Stephen Hantus ◽  
Vineet Punia ◽  
Pravin George
Keyword(s):  
Cardiac Arrest ◽  
Status Epilepticus ◽  
Case Series ◽  
Refractory Status Epilepticus ◽  
Critically Ill Patient ◽  
Unknown Etiology ◽  
High Dose ◽  
The Novel ◽  
Refractory Status ◽  
Symptomatic Seizures

Introduction. Acute symptomatic seizures are frequent in the critically ill patient and can be difficult to treat. The novel anticonvulsant perampanel may be effective in the treatment of status epilepticus considering its mechanism of action of being an AMPA antagonist. We present four cases of super refractory status epilepticus treated with high dose perampanel. Method. Case report. Cases. Four patients were treated with perampanel for their refractory status epilepticus. One patient had new onset refractory status epilepticus of unknown etiology. Three other patients had status epilepticus as a result of their cardiac arrest. Two of the cardiac arrest patients had myoclonus. In all patients, the additional of perampanel resulted in a reduction of seizure burden without affecting hemodynamics or hepatic or renal function. Conclusion. Perampanel may be effective in the treatment of super-refractory status epilepticus of varying etiologies. A larger, prospective study is needed to further assess this therapy.

Rescue therapy with high-dose oral phenobarbitone loading for refractory status epilepticus

2010 ◽  
Vol 46 (1-2) ◽  
pp. 17-22 ◽  
Author(s):  
Jo M Wilmshurst ◽  
Jan-Stefan van der Walt ◽  
Sally Ackermann ◽  
Mats O Karlsson ◽  
Marc Blockman
Keyword(s):  
Status Epilepticus ◽  
Rescue Therapy ◽  
Refractory Status Epilepticus ◽  
High Dose ◽  
Refractory Status ◽  
Dose Oral

Surgical treatment of refractory status epilepticus in children

2013 ◽  
Vol 12 (4) ◽  
pp. 360-366 ◽  
Author(s):  
Sanjiv Bhatia ◽  
Faiz Ahmad ◽  
Ian Miller ◽  
John Ragheb ◽  
Glenn Morrison ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Status Epilepticus ◽  
Intensive Care Unit Stay ◽  
Surgical Intervention ◽  
Refractory Status Epilepticus ◽  
High Dose ◽  
High Morbidity ◽  
Ictal Spect ◽  
Refractory Status

Object Refractory status epilepticus (RSE) is a life-threatening neurological emergency associated with high morbidity and mortality. Affected patients often require prolonged intensive care and can suffer multiple complications. Surgical intervention to control RSE is rarely used but can obviate the risks of prolonged seizures and intensive care treatment. Authors of the present study analyzed their experience with the surgical management of patients suffering from RSE. Methods The Epilepsy Surgery Database at Miami Children's Hospital was reviewed for patients who had undergone surgery for RSE. Clinical presentation, electrophysiological profile, radiological data, surgical details, and postoperative course were evaluated. Results Between 1990 and 2012, 15 patients underwent surgery for uncontrolled seizures despite high-dose medical suppressive therapy. The mean preoperative duration of status epilepticus was 8 weeks. Ictal SPECT and FDG-PET imaging in conjunction with intraoperative electrophysiological studies helped to outline the extent of resection. Surgical intervention controlled seizures in all patients and facilitated the transition out of intensive care. Adverse events related to a prolonged intensive care unit stay included sepsis and respiratory complications. Four patients had worsened neurological function, developing hemiparesis and dysphasia. There was no operative mortality. Conclusions Surgical intervention can successfully control refractory partial status epilepticus, prevent associated morbidity, and decrease intensive care unit stay. Ictal SPECT and PET are valuable in guiding resection.

scholarly journals New Onset Refractory Status Epilepticus in a Young Man with H1N1 Infection

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Faisal Ibrahim ◽  
Naim Haddad
Keyword(s):  
Status Epilepticus ◽  
Influenza Infection ◽  
H1n1 Influenza ◽  
Neurological Complications ◽  
Refractory Status Epilepticus ◽  
Clonic Seizure ◽  
High Dose ◽  
H1n1 Infection ◽  
Refractory Status ◽  
Sedative Drugs

Objective. To report a case of refractory status epilepticus (SE) as an unusual early manifestation of H1N1 influenza infection.Introduction. H1N1 neurological complications have been reported and consist mainly of seizures or encephalopathy occurring in children. However, we only found a single report of an adult developing complex partial SE with H1N1 infection.Case Report. A 21-year-old previously healthy man was brought to the emergency room (ER) after a witnessed generalized tonic clonic seizure (GTCS). He was fully alert and afebrile upon ER arrival, but a second GTCS prompted treatment with Lorazepam and Fosphenytoin. The initial EEG showed diffuse slowing, but a repeat one requested as the patient failed to regain consciousness revealed recurrent focal seizures of independent bihemispheric origin, fulfilling the criteria for nonconvulsive SE. Chest X-ray, followed by chest CT scan, showed a left upper lobe consolidation. H1N1 infection was confirmed with PCR on bronchoalveolar lavage material. Despite aggressive treatment with Midazolam, Propofol, and multiple high dose antiepileptic drugs, the electrographic seizures recurred at every attempt to reduce the intravenous sedative drugs. The patient died two weeks after his initial presentation.Conclusion. H1N1 should be added to the list of rare causes of refractory SE, regardless of the patient’s age.

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