scholarly journals Structure−Activity Relationships of New A,D-Ring Modified Steroids as Aromatase Inhibitors:  Design, Synthesis, and Biological Activity Evaluation

2005 ◽  
Vol 48 (20) ◽  
pp. 6379-6385 ◽  
Author(s):  
Margarida M. D. S. Cepa ◽  
Elisiário J. Tavares da Silva ◽  
Georgina Correia-da-Silva ◽  
Fernanda M. F. Roleira ◽  
Natércia A. A. Teixeira
Keyword(s):  
Biological Activity ◽  
Aromatase Inhibitors ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Activity Evaluation ◽  
Structure Activity

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

2020 ◽  
Vol 44 (6) ◽  
pp. 2247-2255
Author(s):  
Qifan Zhou ◽  
Lina Jia ◽  
Fangyu Du ◽  
Xiaoyu Dong ◽  
Wanyu Sun ◽  
...  
Keyword(s):  
Biological Activity ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Activity Assay ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Enhancer Of Zeste

A novel series of pyrrole-3-carboxamides targeting EZH2 have been designed and synthesized. The structure–activity relationships were summarized by combining with in vitro biological activity assay and docking results.

Design, Synthesis, and Structure–Activity Relationships of Azolylmethylpyrroloquinolines as Nonsteroidal Aromatase Inhibitors

2013 ◽  
Vol 56 (19) ◽  
pp. 7536-7551 ◽  
Author(s):  
Maria Grazia Ferlin ◽  
Davide Carta ◽  
Roberta Bortolozzi ◽  
Razieh Ghodsi ◽  
Adele Chimento ◽  
...  
Keyword(s):  
Aromatase Inhibitors ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Nonsteroidal Aromatase Inhibitors

New Structure–Activity Relationships of A- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis, and Biochemical Evaluation

2012 ◽  
Vol 55 (8) ◽  
pp. 3992-4002 ◽  
Author(s):  
Carla Varela ◽  
Elisiário J. Tavares da Silva ◽  
Cristina Amaral ◽  
Georgina Correia da Silva ◽  
Teresa Baptista ◽  
...  
Keyword(s):  
Aromatase Inhibitors ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Biochemical Evaluation ◽  
Steroidal Aromatase Inhibitors
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