ChemInform Abstract: Novel Indole and Azaindole (Pyrrolopyridine) Cannabinoid (CB) Receptor Agonists: Design, Synthesis, Structure-Activity Relationships, Physicochemical Properties and Biological Activity.

ChemInform ◽  
2012 ◽  
Vol 43 (6) ◽  
pp. no-no
Author(s):  
Antoni R. Blaazer ◽  
Jos H. M. Lange ◽  
Martina A. W. van der Neut ◽  
Arie Mulder ◽  
Femke S. den Boon ◽  
...  
Keyword(s):  
Biological Activity ◽  
Physicochemical Properties ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Receptor Agonists ◽  
Structure Activity

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

2020 ◽  
Vol 44 (6) ◽  
pp. 2247-2255
Author(s):  
Qifan Zhou ◽  
Lina Jia ◽  
Fangyu Du ◽  
Xiaoyu Dong ◽  
Wanyu Sun ◽  
...  
Keyword(s):  
Biological Activity ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Activity Assay ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Enhancer Of Zeste

A novel series of pyrrole-3-carboxamides targeting EZH2 have been designed and synthesized. The structure–activity relationships were summarized by combining with in vitro biological activity assay and docking results.

scholarly journals Structure−Activity Relationships of New A,D-Ring Modified Steroids as Aromatase Inhibitors:  Design, Synthesis, and Biological Activity Evaluation

2005 ◽  
Vol 48 (20) ◽  
pp. 6379-6385 ◽  
Author(s):  
Margarida M. D. S. Cepa ◽  
Elisiário J. Tavares da Silva ◽  
Georgina Correia-da-Silva ◽  
Fernanda M. F. Roleira ◽  
Natércia A. A. Teixeira
Keyword(s):  
Biological Activity ◽  
Aromatase Inhibitors ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Activity Evaluation ◽  
Structure Activity
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