G-Protein-Coupled Receptor Affinity Prediction Based on the Use of a Profiling Dataset:  QSAR Design, Synthesis, and Experimental Validation

2005 ◽  
Vol 48 (21) ◽  
pp. 6563-6574 ◽  
Author(s):  
Catherine Rolland ◽  
Rafael Gozalbes ◽  
Eric Nicolaï ◽  
Marie-France Paugam ◽  
Laurent Coussy ◽  
...  
Keyword(s):  
G Protein ◽  
Experimental Validation ◽  
G Protein Coupled Receptor ◽  
Design Synthesis ◽  
Receptor Affinity ◽  
Affinity Prediction ◽  
G Protein Coupled

Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT1A and 5-HT7 G protein-coupled receptor affinity, 3D-QSAR and molecular modeling

2020 ◽  
Vol 28 (3) ◽  
pp. 115262 ◽  
Author(s):  
Charles K. Perry ◽  
Austen B. Casey ◽  
Daniel E. Felsing ◽  
Rajender Vemula ◽  
Mehreen Zaka ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
G Protein ◽  
3D Qsar ◽  
G Protein Coupled Receptor ◽  
Receptor Affinity ◽  
G Protein Coupled

Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors

2013 ◽  
Vol 69 ◽  
pp. 384-392 ◽  
Author(s):  
Alfonso Carotenuto ◽  
Ersilia Cipolletta ◽  
Isabel Gomez-Monterrey ◽  
Marina Sala ◽  
Ermelinda Vernieri ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Design Synthesis ◽  
G Protein Coupled

Design, Synthesis, and Biological Activity of Potent and Orally Available G Protein-Coupled Receptor 40 Agonists

2011 ◽  
Vol 54 (5) ◽  
pp. 1365-1378 ◽  
Author(s):  
Shinobu Sasaki ◽  
Shuji Kitamura ◽  
Nobuyuki Negoro ◽  
Masami Suzuki ◽  
Yoshiyuki Tsujihata ◽  
...  
Keyword(s):  
Biological Activity ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Design Synthesis ◽  
G Protein Coupled

scholarly journals Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists

2016 ◽  
Vol 8 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Jason M. Cox ◽  
Hong D. Chu ◽  
Mariappan V. Chelliah ◽  
John S. Debenham ◽  
Keith Eagen ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Design Synthesis ◽  
G Protein Coupled

Predicted Ligands for the Human Urotensin-II G Protein-Coupled Receptor with Some Experimental Validation

ChemMedChem ◽  
2014 ◽  
pp. n/a-n/a
Author(s):  
Soo-Kyung Kim ◽  
William A. Goddard ◽  
Kyu Yang Yi ◽  
Byung Ho Lee ◽  
Chae Jo Lim ◽  
...  
Keyword(s):  
G Protein ◽  
Experimental Validation ◽  
Urotensin Ii ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

Design, Synthesis, and Evaluation of N- and C-Terminal Protein Bioconjugates as G Protein-Coupled Receptor Agonists

2018 ◽  
Vol 29 (2) ◽  
pp. 403-409
Author(s):  
Robert D. Healey ◽  
Jonathan P. Wojciechowski ◽  
Ana Monserrat-Martinez ◽  
Susan L. Tan ◽  
Christopher P. Marquis ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Terminal Protein ◽  
Design Synthesis ◽  
Receptor Agonists ◽  
G Protein Coupled
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