Predicted Ligands for the Human Urotensin-II G Protein-Coupled Receptor with Some Experimental Validation

ChemMedChem ◽  
2014 ◽  
pp. n/a-n/a
Author(s):  
Soo-Kyung Kim ◽  
William A. Goddard ◽  
Kyu Yang Yi ◽  
Byung Ho Lee ◽  
Chae Jo Lim ◽  
...  
Keyword(s):  
G Protein ◽  
Experimental Validation ◽  
Urotensin Ii ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

A novel role of G protein-coupled receptor kinase 5 in urotensin II-stimulated cellular hypertrophy in H9c2UT cells

2016 ◽  
Vol 422 (1-2) ◽  
pp. 151-160 ◽  
Author(s):  
Cheon Ho Park ◽  
Ju Hee Lee ◽  
Mi Young Lee ◽  
Jeong Hyun Lee ◽  
Byung Ho Lee ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
Urotensin Ii ◽  
G Protein Coupled Receptor ◽  
Cellular Hypertrophy ◽  
G Protein Coupled

scholarly journals Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor

2017 ◽  
Vol 15 (21) ◽  
pp. 4704-4710 ◽  
Author(s):  
Salvatore Pacifico ◽  
Aidan Kerckhoffs ◽  
Andrew J. Fallow ◽  
Rachel E. Foreman ◽  
Remo Guerrini ◽  
...  
Keyword(s):  
G Protein ◽  
Disulfide Bond ◽  
Covalent Binding ◽  
Urotensin Ii ◽  
Binding Mechanism ◽  
G Protein Coupled Receptor ◽  
High Affinity ◽  
G Protein Coupled ◽  
Insight Into

New high affinity peptidomimetic ligands have been developed that provided new insight into the mechanism of binding of U-II peptide with the urotensin-II receptor.

scholarly journals The G Protein-Coupled Receptor UT of the Neuropeptide Urotensin II Displays Structural and Functional Chemokine Features

2017 ◽  
Vol 8 ◽  
Author(s):  
Hélène Castel ◽  
Laurence Desrues ◽  
Jane-Eileen Joubert ◽  
Marie-Christine Tonon ◽  
Laurent Prézeau ◽  
...  
Keyword(s):  
G Protein ◽  
Urotensin Ii ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

Identification of Urotensin II as the Endogenous Ligand for the Orphan G-Protein-Coupled Receptor GPR14

1999 ◽  
Vol 266 (1) ◽  
pp. 174-178 ◽  
Author(s):  
Qingyun Liu ◽  
Sheng-Shung Pong ◽  
Zhizhen Zeng ◽  
Qing Zhang ◽  
Andrew D. Howard ◽  
...  
Keyword(s):  
G Protein ◽  
Urotensin Ii ◽  
G Protein Coupled Receptor ◽  
Endogenous Ligand ◽  
G Protein Coupled

G-Protein-Coupled Receptor Affinity Prediction Based on the Use of a Profiling Dataset:  QSAR Design, Synthesis, and Experimental Validation

2005 ◽  
Vol 48 (21) ◽  
pp. 6563-6574 ◽  
Author(s):  
Catherine Rolland ◽  
Rafael Gozalbes ◽  
Eric Nicolaï ◽  
Marie-France Paugam ◽  
Laurent Coussy ◽  
...  
Keyword(s):  
G Protein ◽  
Experimental Validation ◽  
G Protein Coupled Receptor ◽  
Design Synthesis ◽  
Receptor Affinity ◽  
Affinity Prediction ◽  
G Protein Coupled

Vanadium compounds cause activation of G protein-coupled receptor signaling

2020 ◽  
Author(s):  
Debbie C. Crans ◽  
Duaa Althumairy ◽  
Heide Murakami ◽  
B. George Barisas ◽  
Deborah Roess
Keyword(s):  
G Protein ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
Vanadium Compounds ◽  
G Protein Coupled
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