A Prodrug Approach toward the Development of Water Soluble Fluoroquinolones and Structure−Activity Relationships of Quinoline-3-carboxylic Acids

William R. Baker; Shaopei Cai; Martin Dimitroff; Liming Fang; Kay K. Huh; David R. Ryckman; Xiao Shang; Ribhi M. Shawar; Joseph H. Therrien

doi:10.1021/jm0497895

A Prodrug Approach toward the Development of Water Soluble Fluoroquinolones and Structure−Activity Relationships of Quinoline-3-carboxylic Acids

Journal of Medicinal Chemistry ◽

10.1021/jm0497895 ◽

2004 ◽

Vol 47 (19) ◽

pp. 4693-4709 ◽

Cited By ~ 28

Author(s):

William R. Baker ◽

Shaopei Cai ◽

Martin Dimitroff ◽

Liming Fang ◽

Kay K. Huh ◽

...

Keyword(s):

Carboxylic Acids ◽

Water Soluble ◽

Structure Activity Relationships ◽

Structure Activity

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Fluoronaphthyridines as antibacterial agents. 4. Synthesis and structure-activity relationships of 5-substituted 6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids

Journal of Medicinal Chemistry ◽

10.1021/jm00081a013 ◽

1992 ◽

Vol 35 (3) ◽

pp. 518-525 ◽

Cited By ~ 52

Author(s):

D. Bouzard ◽

P. Di Cesare ◽

M. Essiz ◽

J. P. Jacquet ◽

B. Ledoussal ◽

...

Keyword(s):

Carboxylic Acids ◽

Antibacterial Agents ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis, Biological Evaluation, and Structure−Activity Relationships of 3-Acylindole-2-carboxylic Acids as Inhibitors of the Cytosolic Phospholipase A2

Journal of Medicinal Chemistry ◽

10.1021/jm960863w ◽

1997 ◽

Vol 40 (17) ◽

pp. 2694-2705 ◽

Cited By ~ 20

Author(s):

Matthias Lehr

Keyword(s):

Phospholipase A2 ◽

Carboxylic Acids ◽

Biological Evaluation ◽

Cytosolic Phospholipase A2 ◽

Structure Activity Relationships ◽

Cytosolic Phospholipase ◽

Structure Activity

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Studies on .BETA.-lactam antibiotics. VIII. Structure-activity relationships of 7.BETA.-((Z)-2-carboxymethoxyimino-2-arylacetamido)-3-cephem-4-carboxylic acids.

The Journal of Antibiotics ◽

10.7164/antibiotics.38.1068 ◽

1985 ◽

Vol 38 (8) ◽

pp. 1068-1076 ◽

Cited By ~ 6

Author(s):

HIDEAKI YAMANAKA ◽

HISASHI TAKASUGI ◽

TAKASHI MASUGI ◽

HIROMU KOCHI ◽

KENJI MIYAI ◽

...

Keyword(s):

Carboxylic Acids ◽

Beta Lactam ◽

Structure Activity Relationships ◽

Beta Lactam Antibiotics ◽

Structure Activity

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Orally active cephalosporins. III. Synthesis and structure-activity relationships of new 3-heterocyclicthiomethylthio-7.BETA.-((Z)-2(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-cephem-4-carboxylic acids.

The Journal of Antibiotics ◽

10.7164/antibiotics.46.316 ◽

1993 ◽

Vol 46 (2) ◽

pp. 316-330 ◽

Cited By ~ 2

Author(s):

MASAHARU KUME ◽

TADATOSHI KUBOTA ◽

YASUO KIMURA ◽

HIROMU NAKASHIMIZU ◽

KIYOSHI MOTOKAWA

Keyword(s):

Carboxylic Acids ◽

Structure Activity Relationships ◽

Structure Activity ◽

Orally Active

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DIRECT AND INDIRECT PHOTOLYSIS OF WATER-SOLUBLE AZODYES: KINETIC MEASUREMENTS AND STRUCTURE-ACTIVITY RELATIONSHIPS

Environmental Toxicology and Chemistry ◽

10.1897/1552-8618(1987)6[359:daipow]2.0.co;2 ◽

1987 ◽

Vol 6 (5) ◽

pp. 359 ◽

Cited By ~ 1

Author(s):

Werner R. Haao ◽

Theodore Mill

Keyword(s):

Water Soluble ◽

Kinetic Measurements ◽

Structure Activity Relationships ◽

Indirect Photolysis ◽

Structure Activity

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Direct and indirect photolysis of water-soluble azodyes: Kinetic measurements and structure-activity relationships

Environmental Toxicology and Chemistry ◽

10.1002/etc.5620060505 ◽

1987 ◽

Vol 6 (5) ◽

pp. 359-369 ◽

Cited By ~ 25

Author(s):

Werner R. Haag ◽

Theodore Mill

Keyword(s):

Water Soluble ◽

Kinetic Measurements ◽

Structure Activity Relationships ◽

Indirect Photolysis ◽

Structure Activity

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Structure-activity relationships of a series of oxysulfonyl carbamate inhibitors of acylCoA: cholesterol O-acyl transferase (ACAT): identification of PD 138142-15, a water-soluble ACAT inhibitor displaying excellent lipid regulation in rats

Atherosclerosis ◽

10.1016/0021-9150(94)93659-5 ◽

1994 ◽

Vol 109 (1-2) ◽

pp. 162 ◽

Cited By ~ 3

Author(s):

J.A. Picard ◽

D.R. Sliskovic ◽

M.K. Anderson ◽

R.F. Bousley ◽

B.R. Krause ◽

...

Keyword(s):

Water Soluble ◽

Acyl Transferase ◽

Structure Activity Relationships ◽

Structure Activity ◽

Acat Inhibitor ◽

Carbamate Inhibitors ◽

Lipid Regulation

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Structure–activity relationships on the odor detectability of homologous carboxylic acids by humans

Experimental Brain Research ◽

10.1007/s00221-010-2430-0 ◽

2010 ◽

Vol 207 (1-2) ◽

pp. 75-84 ◽

Cited By ~ 21

Author(s):

J. Enrique Cometto-Muñiz ◽

Michael H. Abraham

Keyword(s):

Carboxylic Acids ◽

Structure Activity Relationships ◽

Structure Activity

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ChemInform Abstract: OVERCROWDING FACTORS MOSQUITO LARVAE PART 6, STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-SUBSTITUTED ALIPHATIC CARBOXYLIC ACIDS AGAINST MOSQUITO LARVAE

Chemischer Informationsdienst ◽

10.1002/chin.197517199 ◽

1975 ◽

Vol 6 (17) ◽

pp. no-no

Author(s):

Y. S. HWANG ◽

M. S. MULLA ◽

J. R. ARIAS

Keyword(s):

Carboxylic Acids ◽

Mosquito Larvae ◽

Structure Activity Relationships ◽

Structure Activity ◽

Aliphatic Carboxylic Acids

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Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids

Journal of Medicinal Chemistry ◽

10.1021/jm00186a014 ◽

1980 ◽

Vol 23 (12) ◽

pp. 1358-1363 ◽

Cited By ~ 339

Author(s):

Hiroshi Koga ◽

Akira Itoh ◽

Satoshi Murayama ◽

Seigo Suzue ◽

Tsutomu Irikura

Keyword(s):

Carboxylic Acids ◽

Structure Activity Relationships ◽

Structure Activity

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