Synthesis and Antitumor Activity of New Derivatives of Xanthen-9-one-4-acetic Acid

2002 ◽  
Vol 45 (22) ◽  
pp. 4931-4939 ◽  
Author(s):  
Silvia Gobbi ◽  
Angela Rampa ◽  
Alessandra Bisi ◽  
Federica Belluti ◽  
Piero Valenti ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Antitumor Activity ◽  
Derivatives Of

ChemInform Abstract: Synthesis and Antitumor Activity of New Derivatives of Flavone-8- acetic Acid (FAA). Part 1. 6-Methyl Derivatives.

ChemInform ◽  
2010 ◽  
Vol 28 (13) ◽  
pp. no-no
Author(s):  
R. A. AITKEN ◽  
M. C. BIBBY ◽  
J. A. DOUBLE ◽  
R. M. PHILLIPS ◽  
S. K. SHARMA
Keyword(s):  
Acetic Acid ◽  
Antitumor Activity ◽  
Methyl Derivatives ◽  
Derivatives Of

ChemInform Abstract: Synthesis and Antitumor Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 3. 2-Heteroaryl Derivatives.

ChemInform ◽  
2010 ◽  
Vol 30 (13) ◽  
pp. no-no
Author(s):  
R. Alan Aitken ◽  
Michael C. Bibby ◽  
Florian Bielefeldt ◽  
John A. Double ◽  
Andrea L. Laws ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Antitumor Activity ◽  
Derivatives Of

ChemInform Abstract: Synthesis and Antitumor Activity of New Derivatives of Flavone-8- acetic Acid (FAA). Part 2. Ring-Substituted Derivatives

ChemInform ◽  
2010 ◽  
Vol 28 (49) ◽  
pp. no-no
Author(s):  
R. A. AITKEN ◽  
M. C. BIBBY ◽  
J. A. DOUBLE ◽  
A. L. LAWS ◽  
R. B. RITCHIE ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Antitumor Activity ◽  
Derivatives Of

ChemInform Abstract: Synthesis and Antitumor Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 4. Variation of the Basic Structure.

ChemInform ◽  
2000 ◽  
Vol 31 (40) ◽  
pp. no-no
Author(s):  
R. Alan Aitken ◽  
Michael C. Bibby ◽  
Patricia A. Cooper ◽  
John A. Double ◽  
Andrea L. Laws ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Antitumor Activity ◽  
Basic Structure ◽  
Derivatives Of

Synthesis and antitumor activity of novel substituted uracil-1′(N)-acetic acid ester derivatives of 20(S)-camptothecins

2017 ◽  
Vol 125 ◽  
pp. 1235-1246 ◽  
Author(s):  
Di-Zao Li ◽  
Qiang-Zhe Zhang ◽  
Cun-Ying Wang ◽  
Yan-Ling Zhang ◽  
Xing-Yu Li ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Antitumor Activity ◽  
Acid Ester ◽  
Derivatives Of

Fluorinated tricyclic neuroleptics with prolonged action: 8-Methoxy, 8-ethoxy, 8-ethylthio and 8-hydroxy derivatives of 3-fluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin

1982 ◽  
Vol 47 (5) ◽  
pp. 1382-1391 ◽  
Author(s):  
Jiří Jílek ◽  
Josef Pomykáček ◽  
Jiřina Metyšová ◽  
Miroslav Protiva
Keyword(s):  
Acetic Acid ◽  
Polyphosphoric Acid ◽  
Prolonged Action ◽  
Substitution Reactions ◽  
Methoxy Derivative ◽  
Chloro Derivatives ◽  
Boron Tribromide ◽  
Derivatives Of ◽  
Central Depressant ◽  
Boiling Toluene

Acids IIa-c were prepared by reactions of (4-fluoro-2-iodophenyl)acetic acid with 4-methoxythiophenol, 4-ethoxythiophenol and 4-(ethylthio)thiophenol and cyclized with polyphosphoric acid in boiling toluene to dibenzo[b,f]thiepin-10(11H)-ones IIIa-c. Reduction with sodium borohydride afforded the alcohols IVa-c which were treated with hydrogen chloride and gave the chloro derivatives Va-c. Substitution reactions with 1-methylpiperazine resulted in the title compounds Ia-c out of which the methoxy derivative Ia was transformed by demethylation with boron tribromide to the phenol Id. Compounds Ia-d are very potent neuroleptics exhibiting a clear prolongation of the central depressant and some prolongation of the cataleptic activity.

ChemInform Abstract: DIHALO DERIVATIVES OF NAPHTHOSTYRIL-N-ACETIC ACID

1978 ◽  
Vol 9 (34) ◽  
Author(s):  
A. P. KARISHIN ◽  
A. A. PECHKA ◽  
N. F. GRINEVA
Keyword(s):  
Acetic Acid ◽  
Derivatives Of

ChemInform Abstract: SYNTHESIS AND ANTITUMOR ACTIVITY OF 6-OXO-7-AMINO DERIVATIVES OF 5H-PYRIDO(2,3B)- AND 5H-PYRIMIDO(4,5B)(1,4)THIAZINES

1985 ◽  
Vol 16 (15) ◽  
Author(s):  
N. I. TRAVEN' ◽  
YU. A. ERSHOVA ◽  
A. S. SOKOLOVA ◽  
V. A. CHERNOV ◽  
T. S. SAFONOVA
Keyword(s):  
Antitumor Activity ◽  
Amino Derivatives ◽  
Derivatives Of
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