ChemInform Abstract: Synthesis and Antitumor Activity of New Derivatives of Flavone-8- acetic Acid (FAA). Part 1. 6-Methyl Derivatives.

ChemInform ◽  
2010 ◽  
Vol 28 (13) ◽  
pp. no-no
Author(s):  
R. A. AITKEN ◽  
M. C. BIBBY ◽  
J. A. DOUBLE ◽  
R. M. PHILLIPS ◽  
S. K. SHARMA
Keyword(s):  
Acetic Acid ◽  
Antitumor Activity ◽  
Methyl Derivatives ◽  
Derivatives Of

Synthesis and Antitumor Activity of New Derivatives of Xanthen-9-one-4-acetic Acid

2002 ◽  
Vol 45 (22) ◽  
pp. 4931-4939 ◽  
Author(s):  
Silvia Gobbi ◽  
Angela Rampa ◽  
Alessandra Bisi ◽  
Federica Belluti ◽  
Piero Valenti ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Antitumor Activity ◽  
Derivatives Of

ChemInform Abstract: Synthesis and Antitumor Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 3. 2-Heteroaryl Derivatives.

ChemInform ◽  
2010 ◽  
Vol 30 (13) ◽  
pp. no-no
Author(s):  
R. Alan Aitken ◽  
Michael C. Bibby ◽  
Florian Bielefeldt ◽  
John A. Double ◽  
Andrea L. Laws ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Antitumor Activity ◽  
Derivatives Of

Synthesis and Antitumour Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 1: 6-Methyl Derivatives

1996 ◽  
Vol 329 (11) ◽  
pp. 489-497 ◽  
Author(s):  
R. Alan Aitkena ◽  
Michael C. Bibby ◽  
John A. Double ◽  
Roger M. Phillips ◽  
Shiv Kumar Sharma
Keyword(s):  
Acetic Acid ◽  
Antitumour Activity ◽  
Methyl Derivatives ◽  
Derivatives Of

ChemInform Abstract: Synthesis and Anti-Tumor Activity of 6-Methyl Derivatives of Flavone-8- acetic Acid (FAA).

ChemInform ◽  
2010 ◽  
Vol 26 (17) ◽  
pp. no-no
Author(s):  
R. A. AITKEN ◽  
M. C. BIBBY ◽  
J. A. DOUBLE ◽  
R. M. PHILLIPS ◽  
S. K. SHARMA
Keyword(s):  
Acetic Acid ◽  
Methyl Derivatives ◽  
Anti Tumor Activity ◽  
Derivatives Of

ChemInform Abstract: Synthesis and Antitumor Activity of New Derivatives of Flavone-8- acetic Acid (FAA). Part 2. Ring-Substituted Derivatives

ChemInform ◽  
2010 ◽  
Vol 28 (49) ◽  
pp. no-no
Author(s):  
R. A. AITKEN ◽  
M. C. BIBBY ◽  
J. A. DOUBLE ◽  
A. L. LAWS ◽  
R. B. RITCHIE ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Antitumor Activity ◽  
Derivatives Of

Synthesis and anti-tumour activity of 6-methyl derivatives of flavone-8-acetic acid (FAA)

1994 ◽  
Vol 4 (19) ◽  
pp. 2313-2316 ◽  
Author(s):  
R.Alan Aitken ◽  
Michael C. Bibby ◽  
John A. Double ◽  
Roger M. Phillips ◽  
Shiv Kumar Sharma
Keyword(s):  
Acetic Acid ◽  
Anti Tumour Activity ◽  
Methyl Derivatives ◽  
Derivatives Of ◽  
Tumour Activity

ChemInform Abstract: Synthesis and Antitumor Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 4. Variation of the Basic Structure.

ChemInform ◽  
2000 ◽  
Vol 31 (40) ◽  
pp. no-no
Author(s):  
R. Alan Aitken ◽  
Michael C. Bibby ◽  
Patricia A. Cooper ◽  
John A. Double ◽  
Andrea L. Laws ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Antitumor Activity ◽  
Basic Structure ◽  
Derivatives Of

Synthesis and antitumor activity of novel substituted uracil-1′(N)-acetic acid ester derivatives of 20(S)-camptothecins

2017 ◽  
Vol 125 ◽  
pp. 1235-1246 ◽  
Author(s):  
Di-Zao Li ◽  
Qiang-Zhe Zhang ◽  
Cun-Ying Wang ◽  
Yan-Ling Zhang ◽  
Xing-Yu Li ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Antitumor Activity ◽  
Acid Ester ◽  
Derivatives Of

scholarly journals Synthesis and anticonvulsant activity of some 1-cyclohexylidine/ cycloheptylidine-4-substitued semicarbazide derivatives

2017 ◽  
pp. 51-56
Author(s):  
Alok Jain ◽  
Shailendra Patil ◽  
Asmita Gajbhiye
Keyword(s):  
Molecular Weight ◽  
Acetic Acid ◽  
Anticonvulsant Activity ◽  
Sodium Acetate ◽  
Hind Limb ◽  
Glacial Acetic Acid ◽  
The Other ◽  
Methyl Derivatives ◽  
Derivatives Of ◽  
Sodium Cyanate

Aryl semicarbazide derivatives are reported to possess anticonvulsant activity. On the other hand unsubstituted and small substituents (less than 3 carbon atom) containing cyclohexanones prevented both pentylenetetrazole and MES induced seizures. Similarly cycloheptanone fused with benzodiazepine and furan produced anticonvulsant compounds. Therefore looking into the above facts in the present study, we have synthesized 12 derivatives of 1-cyclohexylidine/cycloheptylidine-4-substitued semicarbazide derivatives and screened them for anticonvulsant activity. The synthesis of compounds was achieved as follows: The various para substituted (H, CH3, F,Cl,Br, I) anilines were converted to aryl ureas by reacting with sodium cyanate in the presence of glacial acetic acid. These aryl ureas and aryl semicarbazides were synthesized by allowing them to react with hydrazine hydrate. Finally the aryl semicarbazides were condensed with cyclohexanone/ cycloheptanone in the presence of sodium acetate to give title compounds. All the synthesized compounds were evaluated for anticonvulsant activity by MES method using carbamazepine as standard and it was observed that all the compounds possess anticonvulsant activity comparable to carbamazepine. Carbamazepine had shown the abolition in the hind limb extensor tonic convulsion after 2 sec. whereas few compounds i.e. 1-cyclohexylidine-4-(4-fluorophenyl) semicarbazide, 1-cycloheptylidine-4-(4- fluorophenyl) semi-carbazide and 1-cycloheptylidine-4-phenylsemicarbazide were more active than standard. Overall it was found that cycloheptyl containing compounds were more active than cyclohexyl containing compounds. The unsubstitued compounds were more active than halo derivatives i.e. electron withdrawing groups, and halo compounds were more active than methyl derivatives i.e. electron donating group (CH3). The order of activity for cyclohexanone and cycloheptanone derivatives is as follows: H >F >Cl >Br >I >CH3. Among the halo derivatives, the activity decreased with increasing molecular weight of halo substituents.

Physical Properties of TCNQ Salts with N-Methyl Derivatives of Pyridine

1982 ◽  
Vol 85 (1) ◽  
pp. 257-263 ◽  
Author(s):  
A. Graja ◽  
M. Przybylski ◽  
B. Butka ◽  
R. Swietlik
Keyword(s):  
Physical Properties ◽  
Methyl Derivatives ◽  
Derivatives Of
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